ID   PARE1_MYCTU             Reviewed;          98 AA.
AC   P9WHG7; L0T873; P95255; Q7D7P6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Toxin ParE1;
GN   Name=parE1; OrderedLocusNames=Rv1959c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   EXPRESSION IN E.COLI, AND FUNCTION AS A TOXIN.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=19016878; DOI=10.1111/j.1574-6968.2008.01400.x;
RA   Gupta A.;
RT   "Killing activity and rescue function of genome-wide toxin-antitoxin loci
RT   of Mycobacterium tuberculosis.";
RL   FEMS Microbiol. Lett. 290:45-53(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in E.coli inhibits cell growth and colony formation.
CC       Its toxic effect is neutralized by coexpression with cognate antitoxin
CC       ParD1. {ECO:0000269|PubMed:19016878}.
CC   -!- SIMILARITY: Belongs to the RelE toxin family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44727.1; -; Genomic_DNA.
DR   PIR; C70639; C70639.
DR   RefSeq; NP_216475.1; NC_000962.3.
DR   RefSeq; WP_003409896.1; NZ_NVQJ01000048.1.
DR   AlphaFoldDB; P9WHG7; -.
DR   SMR; P9WHG7; -.
DR   STRING; 83332.Rv1959c; -.
DR   PaxDb; P9WHG7; -.
DR   DNASU; 885958; -.
DR   GeneID; 45425929; -.
DR   GeneID; 885958; -.
DR   KEGG; mtu:Rv1959c; -.
DR   TubercuList; Rv1959c; -.
DR   eggNOG; COG3668; Bacteria.
DR   OMA; RILHGRM; -.
DR   PhylomeDB; P9WHG7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0044003; P:modulation by symbiont of host process; IMP:MTBBASE.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR028344; ParE1/4.
DR   InterPro; IPR007712; RelE/ParE_toxin.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   Pfam; PF05016; ParE_toxin; 1.
DR   PIRSF; PIRSF029218; ParE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..98
FT                   /note="Toxin ParE1"
FT                   /id="PRO_0000408372"
SQ   SEQUENCE   98 AA;  11301 MW;  64ED8124E1610091 CRC64;
     MSSRYLLSPA AQAHLEEIWD CTYDRWGVDQ AEQYLRELQH AIDRAAANPR IGRACDEIRP
     GYRKLSAGSH TLFYRVTGEG TIDVVRVLHQ RMDVDRNL