ID   PARE4_CAUVC             Reviewed;         100 AA.
AC   Q9A459;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Toxin ParE4;
GN   Name=parE4; OrderedLocusNames=CC_2984;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   FUNCTION AS A TOXIN, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=20487277; DOI=10.1111/j.1365-2958.2010.07207.x;
RA   Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.;
RT   "Interaction specificity, toxicity and regulation of a paralogous set of
RT   ParE/RelE-family toxin-antitoxin systems.";
RL   Mol. Microbiol. 77:236-251(2010).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Its
CC       toxic effect is neutralized by coexpression with cognate antitoxin
CC       ParD4 but no other ParD or RelB antitoxin.
CC       {ECO:0000269|PubMed:20487277}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype when deleted singly or as
CC       the parDE4 operon. {ECO:0000269|PubMed:20487277}.
CC   -!- SIMILARITY: Belongs to the RelE toxin family. {ECO:0000305}.
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DR   EMBL; AE005673; AAK24946.1; -; Genomic_DNA.
DR   PIR; F87618; F87618.
DR   RefSeq; NP_421778.1; NC_002696.2.
DR   AlphaFoldDB; Q9A459; -.
DR   SMR; Q9A459; -.
DR   STRING; 190650.CC_2984; -.
DR   EnsemblBacteria; AAK24946; AAK24946; CC_2984.
DR   KEGG; ccr:CC_2984; -.
DR   PATRIC; fig|190650.5.peg.2990; -.
DR   eggNOG; COG3668; Bacteria.
DR   HOGENOM; CLU_147162_3_1_5; -.
DR   OMA; RHGHEDW; -.
DR   BioCyc; CAULO:CC2984-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR028344; ParE1/4.
DR   InterPro; IPR007712; RelE/ParE_toxin.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   Pfam; PF05016; ParE_toxin; 1.
DR   PIRSF; PIRSF029218; ParE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..100
FT                   /note="Toxin ParE4"
FT                   /id="PRO_0000408370"
SQ   SEQUENCE   100 AA;  11184 MW;  C3A3C84F7A4D0D02 CRC64;
     MWIMSYRLSR KAEQDLIDIY VAGVGLFGVA QAERYQDTLE AAFGAIAAFP HIGRERPELR
     PPVRVHPCKS HIILYVLDER GALIVRVRHA GEDWVGEAGG