ID   PARG2_ARATH             Reviewed;         522 AA.
AC   Q8VYA1; Q3EBQ6;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Probable poly(ADP-ribose) glycohydrolase 2;
DE            EC=3.2.1.143 {ECO:0000250|UniProtKB:Q867X0};
GN   Name=PARG2; OrderedLocusNames=At2g31865; ORFNames=F20M17;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Poly(ADP-ribose) synthesized after DNA damage is only present
CC       transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP-
CC         alpha-D-ribose](n-1) + ADP-D-ribose; Xref=Rhea:RHEA:52216, Rhea:RHEA-
CC         COMP:16922, Rhea:RHEA-COMP:16923, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:57967, ChEBI:CHEBI:142512; EC=3.2.1.143;
CC         Evidence={ECO:0000250|UniProtKB:Q867X0};
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8VYA1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8VYA1-2; Sequence=VSP_025763;
CC   -!- SIMILARITY: Belongs to the poly(ADP-ribose) glycohydrolase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Was previously assigned to At2g31870. {ECO:0000305}.
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DR   EMBL; AC006533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002685; AEC08595.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC08596.1; -; Genomic_DNA.
DR   EMBL; AY072330; AAL61937.1; -; mRNA.
DR   EMBL; BT010379; AAQ56822.1; -; mRNA.
DR   RefSeq; NP_850175.1; NM_179844.3. [Q8VYA1-1]
DR   RefSeq; NP_973578.1; NM_201849.3. [Q8VYA1-2]
DR   AlphaFoldDB; Q8VYA1; -.
DR   SMR; Q8VYA1; -.
DR   BioGRID; 3091; 3.
DR   STRING; 3702.AT2G31865.2; -.
DR   PaxDb; Q8VYA1; -.
DR   PRIDE; Q8VYA1; -.
DR   ProteomicsDB; 236275; -. [Q8VYA1-1]
DR   EnsemblPlants; AT2G31865.1; AT2G31865.1; AT2G31865. [Q8VYA1-1]
DR   EnsemblPlants; AT2G31865.2; AT2G31865.2; AT2G31865. [Q8VYA1-2]
DR   GeneID; 817744; -.
DR   Gramene; AT2G31865.1; AT2G31865.1; AT2G31865. [Q8VYA1-1]
DR   Gramene; AT2G31865.2; AT2G31865.2; AT2G31865. [Q8VYA1-2]
DR   KEGG; ath:AT2G31865; -.
DR   Araport; AT2G31865; -.
DR   TAIR; locus:504956053; AT2G31865.
DR   eggNOG; KOG2064; Eukaryota.
DR   HOGENOM; CLU_013388_0_0_1; -.
DR   InParanoid; Q8VYA1; -.
DR   OMA; RICRCMP; -.
DR   OrthoDB; 730627at2759; -.
DR   PhylomeDB; Q8VYA1; -.
DR   PRO; PR:Q8VYA1; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q8VYA1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004649; F:poly(ADP-ribose) glycohydrolase activity; IBA:GO_Central.
DR   GO; GO:1990966; P:ATP generation from poly-ADP-D-ribose; IBA:GO_Central.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:TAIR.
DR   GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IBA:GO_Central.
DR   GO; GO:0006282; P:regulation of DNA repair; IBA:GO_Central.
DR   GO; GO:0031056; P:regulation of histone modification; IBA:GO_Central.
DR   InterPro; IPR046372; PARG_cat.
DR   InterPro; IPR007724; Poly_GlycHdrlase.
DR   PANTHER; PTHR12837; PTHR12837; 1.
DR   Pfam; PF05028; PARG_cat; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Hydrolase; Reference proteome.
FT   CHAIN           1..522
FT                   /note="Probable poly(ADP-ribose) glycohydrolase 2"
FT                   /id="PRO_0000288792"
FT   VAR_SEQ         399
FT                   /note="S -> STKIKFVFAKQ (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_025763"
SQ   SEQUENCE   522 AA;  58943 MW;  6FF98685D867CA15 CRC64;
     MELRADLRSI LQYLPLVAQS SSLVWPPSVE EELQTISRGP SESMVNSGEA LALHITNMRK
     SLSLNASDLA PYALQGYGLF FDKKISREES ANFFGEVVPA LCRLLLQLPS MLEKHYQKAD
     HVLDGVKSGL RLLGPQEAGI VLLSQELIAA LLACSFFCLF PEVDRSLKNL QGINFSGLFS
     FPYMRHCTKQ ENKIKCLIHY FGRICRWMPT GFVSFERKIL PLEYHPHFVS YPKADSWANS
     VTPLCSIEIH TSGAIEDQPC EALEVDFADE YFGGLTLSYD TLQEEIRFVI NPELIAGMIF
     LPRMDANEAI EIVGVERFSG YTGYGPSFQY AGDYTDNKDL DIFRRRKTRV IAIDAMPDPG
     MGQYKLDALI REVNKAFSGY MHQCKYNIDV KHDPEASSSH VPLTSDSASQ VIESSHRWCI
     DHEEKKIGVA TGNWGCGVFG GDPELKIMLQ WLAISQSGRP FMSYYTFGLQ ALQNLNQVIE
     MVALQEMTVG DLWKKLVEYS SERLSRRTWL GFFSWLMTSL ST