ID   PARI_BOVIN              Reviewed;         582 AA.
AC   F1MF21;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 2.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=PCNA-interacting partner;
DE            Short=PARI;
DE   AltName: Full=PARP-1 binding protein;
DE   AltName: Full=PARP1-binding protein;
DE            Short=PARPBP;
GN   Name=PARPBP; Synonyms=PARI;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
CC   -!- FUNCTION: Required to suppress inappropriate homologous recombination,
CC       thereby playing a central role DNA repair and in the maintenance of
CC       genomic stability. Antagonizes homologous recombination by interfering
CC       with the formation of the RAD51-DNA homologous recombination structure.
CC       Binds single-strand DNA and poly(A) homopolymers. Positively regulate
CC       the poly(ADP-ribosyl)ation activity of PARP1; however such function may
CC       be indirect (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RAD51 and PCNA. Interacts with PARP1 (By
CC       similarity). Interacts with TASOR (By similarity).
CC       {ECO:0000250|UniProtKB:Q6IRT3, ECO:0000250|UniProtKB:Q9NWS1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Localizes to chromatin in response to S phase arrest but not in
CC       mitosis. Targeted to chromatin via its interaction with PCNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PARI family. {ECO:0000305}.
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DR   EMBL; DAAA02013696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F1MF21; -.
DR   SMR; F1MF21; -.
DR   STRING; 9913.ENSBTAP00000053842; -.
DR   PaxDb; F1MF21; -.
DR   PRIDE; F1MF21; -.
DR   eggNOG; ENOG502QR2U; Eukaryota.
DR   HOGENOM; CLU_034470_1_0_1; -.
DR   InParanoid; F1MF21; -.
DR   TreeFam; TF332230; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038932; PARPBP.
DR   PANTHER; PTHR32121; PTHR32121; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..582
FT                   /note="PCNA-interacting partner"
FT                   /id="PRO_0000415568"
FT   REGION          471..514
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..489
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   582 AA;  65429 MW;  486F9D7190082C85 CRC64;
     MAGLNQKSIL DMIKEFRRNW HTLCNSERTT VCGADSMLLA LQLSMAENNK QHSGEFTVSL
     SDIILTWKYF LHEKLNLPVE NIKVIDHYED IRKIYDDFLK NSNMLDLIDV YKKCSDLTSN
     CENYANISPS RLLDFLSGRE YAVDDETDFS EPVSPMSKHN QENEKVQLLA KKIIYSYLNL
     LVNSKNDLAL AHILNIPDRG LGREAFTDLK HAAREKQMSI FLVATSFIRT IELGGKGYAP
     SPSDPLRAHI KGLSNFINFI DKLDEILGEV SNPSIAGGRI LSVIKMQLIK GQNSRDPFYK
     AVEEVAQDLD LRIKNIINSQ QGDVALSTTD ISPARPKSHT INHGTAYCGR DTVKALLVLL
     DEEAASAPTK NKAELLYDNE NTIHPNGTSV LTLFRCRSPT QVDNSPMKPL RERIYKSMEE
     KKIKMKQTSI RSQFACTYKD DCMISKDKWN NVNSASEPLC VLHMENDLSE GVNSSVGRPT
     IGTSSGNVHL GRSEKEKVAR KSSSLTGNTS SKRKQVDLDD ENILCDNGNE PLQHKIVKIP
     KTSKDLQNKL DGKLLRVAKS NRCTTKDKLI TGQTKLTQFF RL