PARI_CHICK
ID PARI_CHICK Reviewed; 580 AA.
AC Q5ZKL9; F1NVQ1;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-FEB-2012, sequence version 3.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=PCNA-interacting partner;
DE Short=PARI;
DE AltName: Full=PARP-1 binding protein;
DE AltName: Full=PARP1-binding protein;
DE Short=PARPBP;
GN Name=PARPBP; Synonyms=PARI; ORFNames=RCJMB04_10b14;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
RN [3]
RP FUNCTION.
RX PubMed=22153967; DOI=10.1016/j.molcel.2011.11.010;
RA Moldovan G.L., Dejsuphong D., Petalcorin M.I., Hofmann K., Takeda S.,
RA Boulton S.J., D'Andrea A.D.;
RT "Inhibition of homologous recombination by the PCNA-interacting protein
RT PARI.";
RL Mol. Cell 45:75-86(2012).
CC -!- FUNCTION: Required to suppress inappropriate homologous recombination,
CC thereby playing a central role DNA repair and in the maintenance of
CC genomic stability. {ECO:0000250, ECO:0000269|PubMed:22153967}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Localizes to chromatin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PARI family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG31724.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ720065; CAG31724.1; ALT_SEQ; mRNA.
DR EMBL; AADN02006329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02006330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001025934.2; NM_001030763.2.
DR AlphaFoldDB; Q5ZKL9; -.
DR SMR; Q5ZKL9; -.
DR STRING; 9031.ENSGALP00000040877; -.
DR PaxDb; Q5ZKL9; -.
DR PRIDE; Q5ZKL9; -.
DR GeneID; 418092; -.
DR KEGG; gga:418092; -.
DR CTD; 55010; -.
DR VEuPathDB; HostDB:geneid_418092; -.
DR eggNOG; ENOG502QR2U; Eukaryota.
DR InParanoid; Q5ZKL9; -.
DR OrthoDB; 355941at2759; -.
DR PRO; PR:Q5ZKL9; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IMP:UniProtKB.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038932; PARPBP.
DR PANTHER; PTHR32121; PTHR32121; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA damage; DNA repair; DNA-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..580
FT /note="PCNA-interacting partner"
FT /id="PRO_0000280272"
FT REGION 525..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 117
FT /note="A -> E (in Ref. 1; CAG31724)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="C -> R (in Ref. 1; CAG31724)"
FT /evidence="ECO:0000305"
FT CONFLICT 247
FT /note="V -> I (in Ref. 1; CAG31724)"
FT /evidence="ECO:0000305"
FT CONFLICT 442
FT /note="S -> G (in Ref. 1; CAG31724)"
FT /evidence="ECO:0000305"
FT CONFLICT 464
FT /note="Q -> H (in Ref. 1; CAG31724)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 580 AA; 65151 MW; 0D2496740CEA7529 CRC64;
MISFQQKILN LIKCFRRQWP LFSNSERTTV CGADRMLTAL QLSMAEVNKQ HHGDFAVSPS
DVMETWKYLL HDKLGLSYEN MEEPENYAAF KEAYHTFLAS SNMLDIIDIY QKCCALALLS
EDERIAPIQL LEFISGAMNV SESNGSVLPS TPVNRQDQSS VKVMLFAKNC FYSYLSLLVN
SKDDLALACI LNVPDRGLGR EAFTKLKHAS RERKMSIFLM ATSFIRTVEH GGKGCAASLF
DPLRVHVKEL SNFINFIDKL GEIVGEIPDP RVAGGQILST VKMHLMKGQS NGDPFYQAVE
KVVQDLDLKI KNIIDSQHEV LTASTTGVSP TRPKLHSINH GTAYCGRDTI KVLLVLLDEE
AVSAPTQNKA ELLYDDVNLN MFGITSVLTL FRSPAQSKES SPKPSRQRIQ KPVNEKIIKM
KRSSIKSQFA CTYKNELSKI RSQHFLSSSQ VPACMHPAPK QHLQGKYFTE GMNSCLDIPV
LGTISENVHQ NRNYREMGKL SCQPRNKNSK NEQMDLNNDN VIHDEESETS LPKNAKKLKT
SNNPQKELDS KIGGKRKNNR TASKNKLIVG QAKLTQFFKL
