ID   PARI_DANRE              Reviewed;         568 AA.
AC   Q1RMA6;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=PCNA-interacting partner;
DE            Short=PARI;
DE   AltName: Full=PARP-1 binding protein;
DE   AltName: Full=PARP1-binding protein;
DE            Short=PARPBP;
GN   Name=parpbp; Synonyms=pari; ORFNames=zgc:136263;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required to suppress inappropriate homologous recombination,
CC       thereby playing a central role DNA repair and in the maintenance of
CC       genomic stability. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Localizes to chromatin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PARI family. {ECO:0000305}.
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DR   EMBL; BC115059; AAI15060.1; -; mRNA.
DR   AlphaFoldDB; Q1RMA6; -.
DR   SMR; Q1RMA6; -.
DR   STRING; 7955.ENSDARP00000041528; -.
DR   PaxDb; Q1RMA6; -.
DR   ZFIN; ZDB-GENE-060421-5714; parpbp.
DR   eggNOG; ENOG502QR2U; Eukaryota.
DR   InParanoid; Q1RMA6; -.
DR   PhylomeDB; Q1RMA6; -.
DR   PRO; PR:Q1RMA6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   InterPro; IPR038932; PARPBP.
DR   PANTHER; PTHR32121; PTHR32121; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..568
FT                   /note="PCNA-interacting partner"
FT                   /id="PRO_0000280273"
FT   REGION          442..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..504
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        506..531
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   568 AA;  62469 MW;  893F75F003609797 CRC64;
     MARVFRRECH RVLDSERTTI QGADGMLMVP QLAIAGVNKQ ERGDFGVALS EVLAVWKYFL
     LDKLQLSHKD IPLPQSYDLI RKEYDCFLKR TNTVDLIDVF SMFKELRLNE DPEEPLTTMQ
     MFQFLFGENE SSEKPSQPVC PATPSCKAAD CSPQIQRVVR RVFCSYLDLL VNSKNDLALT
     YTLDNPNRSL GHTAFTDLRH AACDSASSLF LTVTSFVRAI QLGGKGYAPP ESHPLRKHVK
     GLSEFLNFVD QCQDILGETP NPREAGCKLV SSIRAALVKG RSAGDPVYLA AEESTKSLKE
     RIGQIHAMHT QSTVGTGISP ARPKAYAINH ATAYGGRETV KVLMALLDEE ALALPCRNKA
     ELLSEDHAAL NGSTGACLLA LYKSPEAPTG SSPKSLRNRV LSQQEHIKSK VVRPTIRSQF
     ACTYKEEELP LNRVLEFPST SQIPTCVHPA PKKASSESDN GMDNRFKEAT NLRCEGPGQS
     ALGEHSGNAW NQTGGKSTQP EPLRRATGTL KRKLANRECT EQGREENQPP QKRPPAKAAT
     GGPGKRNNKA VSKKLIAGQG KLTGFFRL