ID   PARI_XENLA              Reviewed;         567 AA.
AC   Q32N66;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=PCNA-interacting partner;
DE            Short=PARI;
DE   AltName: Full=PARP-1 binding protein;
DE   AltName: Full=PARP1-binding protein;
DE            Short=PARPBP;
GN   Name=parpbp; Synonyms=pari;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required to suppress inappropriate homologous recombination,
CC       thereby playing a central role DNA repair and in the maintenance of
CC       genomic stability. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Localizes to chromatin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PARI family. {ECO:0000305}.
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DR   EMBL; BC108807; AAI08808.1; -; mRNA.
DR   RefSeq; NP_001089910.1; NM_001096441.1.
DR   AlphaFoldDB; Q32N66; -.
DR   DNASU; 734977; -.
DR   GeneID; 734977; -.
DR   KEGG; xla:734977; -.
DR   CTD; 734977; -.
DR   Xenbase; XB-GENE-1004679; parpbp.L.
DR   OrthoDB; 355941at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 734977; Expressed in egg cell and 9 other tissues.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   InterPro; IPR038932; PARPBP.
DR   PANTHER; PTHR32121; PTHR32121; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..567
FT                   /note="PCNA-interacting partner"
FT                   /id="PRO_0000280274"
FT   REGION          485..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        533..552
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  63048 MW;  F9BCA39D9B668091 CRC64;
     MDCPHQDVLH LIKYFRKEWP VVSDSERTTI CGADNMLLTL QLALAEVNKQ NGKEFSVSLS
     DVLLTWKYLV KHKLGLACED TVVPKDYADI QKTYDLFLKN SNSLDLIDIY EKISTAGSSE
     AHFLSSEQLL DFLTNDVCLS EGTDFPIVST PCKNNLDTVK VKPTLKRIFL AYLNLLVNAK
     NDFALAQVLN CPERGLGREA FTDLKHTSRL KNMSIFLVAT SFIRTIELGG KGYAPSESDP
     LRKHLKGLSL FVHFIDRLNE IFGETHDPRT AGELLLSTIK MHLIKGRGSG DPLSEAATEV
     AQDLDLRIKY LINLVSEDKS SGTTGISPVR PKIRAINRGT ASGGRETIKT LLKLLDEEAA
     NPPSKNKADL LCADEENTLF GAFSLFTLFR SPEQTGSSPK ALSQRVQKAI NKDKPKLKHN
     LIRSQFACTY KDSNLTQTKQ WDFPSMSQVP SCIHPAPKIV PVLCFDEEPL ENDLQKGLKQ
     SSGNIDLKTA EQVKNKPCKN VGNKRSKRKQ VDIQSETTNG QENEPPQKKA VVELTSSKAN
     KQGVSRNKAS KNKLITGQAK LTSFFRV