ID   PARI_XENTR              Reviewed;         573 AA.
AC   Q28EM3; F6V1A0;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 2.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=PCNA-interacting partner;
DE            Short=PARI;
DE   AltName: Full=PARP-1 binding protein;
DE   AltName: Full=PARP1-binding protein;
DE            Short=PARPBP;
GN   Name=parpbp; Synonyms=pari; ORFNames=TGas059b17.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- FUNCTION: Required to suppress inappropriate homologous recombination,
CC       thereby playing a central role DNA repair and in the maintenance of
CC       genomic stability. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Localizes to chromatin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PARI family. {ECO:0000305}.
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DR   EMBL; CR848174; CAJ83439.1; -; mRNA.
DR   EMBL; AAMC01063148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01063149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001039039.1; NM_001045574.1.
DR   AlphaFoldDB; Q28EM3; -.
DR   STRING; 8364.ENSXETP00000005393; -.
DR   PaxDb; Q28EM3; -.
DR   Ensembl; ENSXETT00000005393; ENSXETP00000005393; ENSXETG00000002534.
DR   GeneID; 733805; -.
DR   KEGG; xtr:733805; -.
DR   CTD; 55010; -.
DR   Xenbase; XB-GENE-1004674; parpbp.
DR   eggNOG; ENOG502QR2U; Eukaryota.
DR   HOGENOM; CLU_034470_1_0_1; -.
DR   InParanoid; Q28EM3; -.
DR   OMA; SDVLMTW; -.
DR   OrthoDB; 355941at2759; -.
DR   TreeFam; TF332230; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000002534; Expressed in egg cell and 8 other tissues.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038932; PARPBP.
DR   PANTHER; PTHR32121; PTHR32121; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..573
FT                   /note="PCNA-interacting partner"
FT                   /id="PRO_0000280275"
FT   REGION          492..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        434
FT                   /note="G -> S (in Ref. 1; CAJ83439)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        461
FT                   /note="A -> V (in Ref. 1; CAJ83439)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        548
FT                   /note="T -> P (in Ref. 1; CAJ83439)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   573 AA;  63961 MW;  2D9B866A3BEBA7D9 CRC64;
     MDCPLENVLD LIKYFRKEWP VVSDSERTTI YGADNMLLTL QLALAEVNKQ NGKEFSASLS
     DVLLTWKCLV KHKLGLAYED TAVPENYADI RKTYELFLKT SNSLDLIDIY EKISTLGSSE
     PHNFTSEQLL EFLTEDECFS GDKDFPVVST PCKNNFDVVK VKATLKRIFL AYLNLLVNSK
     NDFALAQVLN CPERGLGREA FTDLKHTSRM KNMSLFLVAT SFIRTIELGG KGYAPSESDP
     LRKHLKGLSL FVHFVDRLNE VLGETNDPRT AGELLLSTIK MHLIKGRSSG DPLSEAATDV
     AQDLDLRIKN LINLLSEDKY SVTPGISPAR PKIHAINRGT ASGGREMIKT LLKLLDEEAA
     NPPSKNKADL LCADEENTLF GAVSLFTLFR SPEQKNGSSP KPLSHRVQKA MDKNKPKLKQ
     NLIRSQFACT YKDGNLAQIK QWDFPSLSQV PTCIHPAPRI APVLCFDEEP LENSDLQKQE
     LKLSSGNIDL KTGGQVKNKP CKNVANKRSK RKQVDIQSET TNAQENEPPQ KKAVVEITSK
     KENKPCVTRN CNKSSSKNKL IAGQAKLTSF FRV