PARM1_HUMAN
ID PARM1_HUMAN Reviewed; 310 AA.
AC Q6UWI2; B3KMQ9; Q96DV8; Q9Y4S1;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Prostate androgen-regulated mucin-like protein 1;
DE Short=PARM-1;
DE Flags: Precursor;
GN Name=PARM1; ORFNames=UNQ1879/PRO4322;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-127.
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 21-35.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [6]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND GLYCOSYLATION.
RX PubMed=18027867; DOI=10.1002/ijc.23185;
RA Fladeby C., Gupta S.N., Barois N., Lorenzo P.I., Simpson J.C.,
RA Saatcioglu F., Bakke O.;
RT "Human PARM-1 is a novel mucin-like, androgen-regulated gene exhibiting
RT proliferative effects in prostate cancer cells.";
RL Int. J. Cancer 122:1229-1235(2008).
RN [7]
RP GLYCOSYLATION AT ASN-80.
RX PubMed=19139490; DOI=10.1074/mcp.m800504-mcp200;
RA Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B.,
RA Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L.,
RA Ying W.T., He S.M., Qian X.H.;
RT "A strategy for precise and large scale identification of core fucosylated
RT glycoproteins.";
RL Mol. Cell. Proteomics 8:913-923(2009).
CC -!- FUNCTION: May regulate TLP1 expression and telomerase activity, thus
CC enabling certain prostatic cells to resist apoptosis. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6UWI2; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-12350959, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18027867};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}.
CC Golgi apparatus membrane {ECO:0000269|PubMed:18027867}; Single-pass
CC type I membrane protein {ECO:0000269|PubMed:18027867}. Endosome
CC membrane {ECO:0000269|PubMed:18027867}; Single-pass type I membrane
CC protein {ECO:0000269|PubMed:18027867}.
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in heart,
CC kidney and placenta. {ECO:0000269|PubMed:18027867}.
CC -!- INDUCTION: By androgens. {ECO:0000269|PubMed:18027867}.
CC -!- PTM: Highly N-glycosylated and O-glycosylated.
CC {ECO:0000269|PubMed:18027867, ECO:0000269|PubMed:19139490}.
CC -!- SIMILARITY: Belongs to the PARM family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB45720.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY358777; AAQ89137.1; -; mRNA.
DR EMBL; AL080121; CAB45720.1; ALT_FRAME; mRNA.
DR EMBL; AK022311; BAG51071.1; -; mRNA.
DR EMBL; BC013294; AAH13294.1; -; mRNA.
DR CCDS; CCDS47077.1; -.
DR PIR; T12458; T12458.
DR RefSeq; NP_056208.2; NM_015393.3.
DR AlphaFoldDB; Q6UWI2; -.
DR BioGRID; 117373; 18.
DR IntAct; Q6UWI2; 1.
DR STRING; 9606.ENSP00000370224; -.
DR GlyGen; Q6UWI2; 4 sites.
DR iPTMnet; Q6UWI2; -.
DR PhosphoSitePlus; Q6UWI2; -.
DR BioMuta; PARM1; -.
DR DMDM; 74738099; -.
DR jPOST; Q6UWI2; -.
DR MassIVE; Q6UWI2; -.
DR MaxQB; Q6UWI2; -.
DR PaxDb; Q6UWI2; -.
DR PeptideAtlas; Q6UWI2; -.
DR PRIDE; Q6UWI2; -.
DR ProteomicsDB; 67482; -.
DR Antibodypedia; 52400; 31 antibodies from 10 providers.
DR DNASU; 25849; -.
DR Ensembl; ENST00000307428.7; ENSP00000370224.3; ENSG00000169116.11.
DR GeneID; 25849; -.
DR KEGG; hsa:25849; -.
DR MANE-Select; ENST00000307428.7; ENSP00000370224.3; NM_015393.4; NP_056208.2.
DR UCSC; uc003hih.3; human.
DR CTD; 25849; -.
DR DisGeNET; 25849; -.
DR GeneCards; PARM1; -.
DR HGNC; HGNC:24536; PARM1.
DR HPA; ENSG00000169116; Low tissue specificity.
DR MIM; 617688; gene.
DR neXtProt; NX_Q6UWI2; -.
DR OpenTargets; ENSG00000169116; -.
DR PharmGKB; PA165664393; -.
DR VEuPathDB; HostDB:ENSG00000169116; -.
DR eggNOG; ENOG502S50N; Eukaryota.
DR GeneTree; ENSGT00390000014545; -.
DR HOGENOM; CLU_898790_0_0_1; -.
DR InParanoid; Q6UWI2; -.
DR OMA; FLIMQEV; -.
DR OrthoDB; 1404104at2759; -.
DR PhylomeDB; Q6UWI2; -.
DR TreeFam; TF335903; -.
DR PathwayCommons; Q6UWI2; -.
DR SignaLink; Q6UWI2; -.
DR BioGRID-ORCS; 25849; 12 hits in 1066 CRISPR screens.
DR ChiTaRS; PARM1; human.
DR GeneWiki; DKFZP564O0823; -.
DR GenomeRNAi; 25849; -.
DR Pharos; Q6UWI2; Tbio.
DR PRO; PR:Q6UWI2; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q6UWI2; protein.
DR Bgee; ENSG00000169116; Expressed in urethra and 189 other tissues.
DR ExpressionAtlas; Q6UWI2; baseline and differential.
DR Genevisible; Q6UWI2; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005769; C:early endosome; IDA:UniProtKB.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005770; C:late endosome; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0051973; P:positive regulation of telomerase activity; ISS:UniProtKB.
DR InterPro; IPR031431; PARM1.
DR PANTHER; PTHR35453; PTHR35453; 1.
DR Pfam; PF17061; PARM; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Direct protein sequencing; Endosome; Glycoprotein;
KW Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 21..310
FT /note="Prostate androgen-regulated mucin-like protein 1"
FT /id="PRO_0000045498"
FT TOPO_DOM 21..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 40..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 298
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P9X9"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) (complex) asparagine"
FT /evidence="ECO:0000269|PubMed:19139490"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 127
FT /note="S -> L (in dbSNP:rs3822109)"
FT /evidence="ECO:0000269|PubMed:11230166"
FT /id="VAR_062257"
FT CONFLICT 82
FT /note="S -> P (in Ref. 3; BAG51071)"
FT /evidence="ECO:0000305"
FT CONFLICT 123
FT /note="E -> K (in Ref. 4; AAH13294)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 32289 MW; 0DFD58B134FAF9BD CRC64;
MVYKTLFALC ILTAGWRVQS LPTSAPLSVS LPTNIVPPTT IWTSSPQNTD ADTASPSNGT
HNNSVLPVTA SAPTSLLPKN ISIESREEEI TSPGSNWEGT NTDPSPSGFS STSGGVHLTT
TLEEHSSGTP EAGVAATLSQ SAAEPPTLIS PQAPASSPSS LSTSPPEVFS ASVTTNHSST
VTSTQPTGAP TAPESPTEES SSDHTPTSHA TAEPVPQEKT PPTTVSGKVM CELIDMETTT
TFPRVIMQEV EHALSSGSIA AITVTVIAVV LLVFGVAAYL KIRHSSYGRL LDDHDYGSWG
NYNNPLYDDS
