PARM1_MOUSE
ID PARM1_MOUSE Reviewed; 296 AA.
AC Q923D3; A5JSU4; Q3TTV0; Q3UFU4;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Prostate androgen-regulated mucin-like protein 1 homolog;
DE Short=PARM-1;
DE Flags: Precursor;
GN Name=Parm1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Adipose tissue;
RA Roh S., Song S., Sasaki S.;
RT "The expression of a mouse homolog of rat prostatic androgen-repressed
RT message-1 (PARM-1), on adipogenesis.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, Head, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May regulate TLP1 expression and telomerase activity, thus
CC enabling certain prostatic cells to resist apoptosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}. Endosome membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC -!- PTM: Highly N-glycosylated and O-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PARM family. {ECO:0000305}.
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DR EMBL; EF564364; ABQ42567.1; -; mRNA.
DR EMBL; AK078943; BAC37472.1; -; mRNA.
DR EMBL; AK148300; BAE28465.1; -; mRNA.
DR EMBL; AK161172; BAE36224.1; -; mRNA.
DR EMBL; AK167402; BAE39491.1; -; mRNA.
DR EMBL; CH466617; EDL05291.1; -; Genomic_DNA.
DR EMBL; BC006604; AAH06604.1; -; mRNA.
DR CCDS; CCDS39146.1; -.
DR RefSeq; NP_663537.1; NM_145562.2.
DR AlphaFoldDB; Q923D3; -.
DR STRING; 10090.ENSMUSP00000042844; -.
DR GlyGen; Q923D3; 3 sites.
DR iPTMnet; Q923D3; -.
DR PhosphoSitePlus; Q923D3; -.
DR MaxQB; Q923D3; -.
DR PaxDb; Q923D3; -.
DR PRIDE; Q923D3; -.
DR ProteomicsDB; 294159; -.
DR Antibodypedia; 52400; 31 antibodies from 10 providers.
DR DNASU; 231440; -.
DR Ensembl; ENSMUST00000040576; ENSMUSP00000042844; ENSMUSG00000034981.
DR GeneID; 231440; -.
DR KEGG; mmu:231440; -.
DR UCSC; uc008ybw.1; mouse.
DR CTD; 25849; -.
DR MGI; MGI:2443349; Parm1.
DR VEuPathDB; HostDB:ENSMUSG00000034981; -.
DR eggNOG; ENOG502S50N; Eukaryota.
DR GeneTree; ENSGT00390000014545; -.
DR HOGENOM; CLU_898790_0_0_1; -.
DR InParanoid; Q923D3; -.
DR OMA; FLIMQEV; -.
DR OrthoDB; 1404104at2759; -.
DR PhylomeDB; Q923D3; -.
DR TreeFam; TF335903; -.
DR BioGRID-ORCS; 231440; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Parm1; mouse.
DR PRO; PR:Q923D3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q923D3; protein.
DR Bgee; ENSMUSG00000034981; Expressed in gastrula and 290 other tissues.
DR Genevisible; Q923D3; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0051973; P:positive regulation of telomerase activity; ISS:UniProtKB.
DR InterPro; IPR031431; PARM1.
DR PANTHER; PTHR35453; PTHR35453; 1.
DR Pfam; PF17061; PARM; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Endosome; Glycoprotein; Golgi apparatus; Membrane;
KW Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..296
FT /note="Prostate androgen-regulated mucin-like protein 1
FT homolog"
FT /id="PRO_0000045499"
FT TOPO_DOM 21..244
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..296
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 72..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 284
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P9X9"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 122
FT /note="L -> I (in Ref. 2; BAE28465)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="T -> I (in Ref. 2; BAE36224)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 296 AA; 30667 MW; 8446AE7E3265936C CRC64;
MVCKVLIALC IFTAGLRVQG SPTVPLPVSL MTKSSAPVAT WTTSAPHTAR ATTPVASATH
NASVLRTTAA SLTSQLPTDH REEAVTSPPL KRDVNSTDSS PAGFPSTSSD GHLAPTPEEH
SLGSPEATVP ATGSQSPMLL SSQAPTSATT SPATSLSESL SASVTSSHNS TVANIQPTEA
PMAPASPTEE HSSSHTPTSH VTAEPVPKEK SPQDTEPGKV ICESETTTPF LIMQEVENAL
SSGSIAAITV TVIAVVLLVF GGAAYLKIRH SSYGRLLDDH DYGSWGNYNN PLYDDS
