ID   PARM1_PONAB             Reviewed;         310 AA.
AC   Q5RAF8;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Prostate androgen-regulated mucin-like protein 1 homolog;
DE            Short=PARM-1;
DE   Flags: Precursor;
GN   Name=PARM1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate TLP1 expression and telomerase activity, thus
CC       enabling certain prostatic cells to resist apoptosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC   -!- PTM: Highly N-glycosylated and O-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PARM family. {ECO:0000305}.
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DR   EMBL; CR859059; CAH91252.1; -; mRNA.
DR   RefSeq; NP_001127394.1; NM_001133922.1.
DR   AlphaFoldDB; Q5RAF8; -.
DR   STRING; 9601.ENSPPYP00000016570; -.
DR   Ensembl; ENSPPYT00000037109; ENSPPYP00000036653; ENSPPYG00000014840.
DR   GeneID; 100174461; -.
DR   KEGG; pon:100174461; -.
DR   CTD; 25849; -.
DR   eggNOG; ENOG502S50N; Eukaryota.
DR   GeneTree; ENSGT00390000014545; -.
DR   HOGENOM; CLU_898790_0_0_1; -.
DR   InParanoid; Q5RAF8; -.
DR   OrthoDB; 1404104at2759; -.
DR   Proteomes; UP000001595; Chromosome 4.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0051973; P:positive regulation of telomerase activity; ISS:UniProtKB.
DR   InterPro; IPR031431; PARM1.
DR   PANTHER; PTHR35453; PTHR35453; 1.
DR   Pfam; PF17061; PARM; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endosome; Glycoprotein; Golgi apparatus; Membrane;
KW   Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..310
FT                   /note="Prostate androgen-regulated mucin-like protein 1
FT                   homolog"
FT                   /id="PRO_0000045500"
FT   TOPO_DOM        21..258
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        280..310
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          40..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         298
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P9X9"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        80
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        176
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   310 AA;  32371 MW;  E1E0A26ED60E77D2 CRC64;
     MVYKTLFALC ILTAGWRVQS LPTSAPLSVS LPTNIMPPTT IWTSSPQNTD ADTASPSNGT
     HNNSVLPVTA SAPTSLLPKN ISVESREEEI TSPGSNWEGT NTDPSPPGFS STSGGVHLTT
     TLEEHSLGTP EAGVAATLSQ SAAEPPTLIS PQAPASSPSS LSTSPPEVFS VSVTTNHSST
     VTSTQPTGAP TAPESPTEES SSDHTPTSHA TAEPVPQEKT PPTTVSGKVM CELIDMETTT
     TFPRVIMQEV EHALSSGSIA AITVTVIAVV LLVFGVAAYL KIRHSSYGRL LDDHDYGSWG
     NYNNPLYDDS