PARM1_RAT
ID PARM1_RAT Reviewed; 296 AA.
AC Q6P9X9; Q9Z0P0;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Prostate androgen-regulated mucin-like protein 1 homolog;
DE Short=PARM-1;
DE AltName: Full=Castration-induced prostatic apoptosis-related protein 1;
DE Short=CIPAR-1;
DE AltName: Full=Prostatic androgen-repressed message 1 protein;
DE Flags: Precursor;
GN Name=Parm1; Synonyms=Cipar1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
RC STRAIN=Wistar;
RX PubMed=10499539; DOI=10.1210/endo.140.10.7097;
RA Bruyninx M., Hennuy B., Cornet A., Houssa P., Daukandt M., Reiter E.,
RA Poncin J., Closset J., Hennen G.;
RT "A novel gene overexpressed in the prostate of castrated rats: hormonal
RT regulation, relationship to apoptosis and to acquired prostatic cell
RT androgen independence.";
RL Endocrinology 140:4789-4799(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Wistar;
RX PubMed=12772192; DOI=10.1002/pros.10254;
RA Cornet A.M., Hanon E., Reiter E.R., Bruyninx M., Nguyen V.H., Hennuy B.R.,
RA Hennen G.P., Closset J.L.;
RT "Prostatic androgen repressed message-1 (PARM-1) may play a role in
RT prostatic cell immortalisation.";
RL Prostate 56:220-230(2003).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: May regulate TLP1 expression and telomerase activity, thus
CC enabling certain prostatic cells to resist apoptosis.
CC {ECO:0000269|PubMed:10499539, ECO:0000269|PubMed:12772192}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}. Endosome membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in prostate. Detected in other organs at
CC low levels, these include the heart and various tissues of the
CC urogenital tract. Not detected in mammary gland.
CC {ECO:0000269|PubMed:12772192}.
CC -!- INDUCTION: Induced in prostate, after castration. This induction is
CC reversed by androgen supplementation. {ECO:0000269|PubMed:10499539}.
CC -!- PTM: Highly N-glycosylated and O-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PARM family. {ECO:0000305}.
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DR EMBL; AJ010750; CAB38095.1; -; mRNA.
DR EMBL; BC060539; AAH60539.1; -; mRNA.
DR RefSeq; NP_775137.1; NM_173114.1.
DR AlphaFoldDB; Q6P9X9; -.
DR STRING; 10116.ENSRNOP00000003472; -.
DR GlyGen; Q6P9X9; 4 sites.
DR iPTMnet; Q6P9X9; -.
DR PhosphoSitePlus; Q6P9X9; -.
DR PaxDb; Q6P9X9; -.
DR GeneID; 286894; -.
DR KEGG; rno:286894; -.
DR UCSC; RGD:708342; rat.
DR CTD; 25849; -.
DR RGD; 708342; Parm1.
DR eggNOG; ENOG502S50N; Eukaryota.
DR InParanoid; Q6P9X9; -.
DR OrthoDB; 1404104at2759; -.
DR PhylomeDB; Q6P9X9; -.
DR PRO; PR:Q6P9X9; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; NAS:RGD.
DR GO; GO:0051973; P:positive regulation of telomerase activity; IMP:UniProtKB.
DR InterPro; IPR031431; PARM1.
DR PANTHER; PTHR35453; PTHR35453; 1.
DR Pfam; PF17061; PARM; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Endosome; Glycoprotein; Golgi apparatus; Membrane;
KW Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..296
FT /note="Prostate androgen-regulated mucin-like protein 1
FT homolog"
FT /id="PRO_0000045501"
FT TOPO_DOM 21..244
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..296
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 73..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 284
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 17
FT /note="R -> M (in Ref. 1; CAB38095)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="S -> SGS (in Ref. 1; CAB38095)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 296 AA; 30729 MW; 450846B6BD760617 CRC64;
MVCKALITLC IFAAGLRVQG SPTPTLLPVS LTTKSTAPMA TWTTSAQHTA MATTPVASAT
HNASVLRTTA ASLTSQLPTH PREEAVTSPP LKREVNSTDS SPTGFSSNSS GIHLAPTPEE
HSLGSPETSV PATGSQSPTL LFSQGPTSAS TSPATSPSEP LSASVTSNHS STVNNIQPTG
APMAPASPTE EHSSSHTPTS HVTEPVPKEK SPQDTEPGKV ICESETTTPF LIMQEVENAL
SSGSIAAITV TVIAVVLLVF GAAAYLKIRH SSYGRLLDDH DYGSWGNYNN PLYDDS
