PAT12_CAEEL
ID PAT12_CAEEL Reviewed; 663 AA.
AC Q95QA6; H2KYY3; H2KYY4; H2KYY5; H2KYY6; H2KYY7; H2KYY8; H2KYY9; H2KYZ0;
AC H2KYZ1; H2KYZ2; Q8MPW4;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Protein pat-12 {ECO:0000305};
DE AltName: Full=Paralyzed arrest at two-fold 12 protein {ECO:0000312|WormBase:T17H7.4a};
GN Name=pat-12 {ECO:0000312|WormBase:T17H7.4a};
GN ORFNames=T17H7.4 {ECO:0000312|WormBase:T17H7.4a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, INTERACTION WITH VAB-10, SUBCELLULAR LOCATION, ALTERNATIVE
RP SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=21130760; DOI=10.1016/j.ydbio.2010.11.025;
RA Hetherington S., Gally C., Fritz J.A., Polanowska J., Reboul J., Schwab Y.,
RA Zahreddine H., Behm C., Labouesse M.;
RT "PAT-12, a potential anti-nematode target, is a new spectraplakin partner
RT essential for Caenorhabditis elegans hemidesmosome integrity and embryonic
RT morphogenesis.";
RL Dev. Biol. 350:267-278(2011).
CC -!- FUNCTION: [Isoform a]: Required for embryonic morphology and
CC development. Plays both a functional and a structural role in the
CC maintenance and probably biogenesis of fibrous organelles, a
CC hemidesomosome-like junction structure, which ensures muscle stability
CC and muscle connection to the external cuticle.
CC {ECO:0000269|PubMed:21130760}.
CC -!- SUBUNIT: Interacts with vab-10 (via plankin domain).
CC {ECO:0000269|PubMed:21130760}.
CC -!- INTERACTION:
CC Q95QA6; P03949: abl-1; NbExp=3; IntAct=EBI-327642, EBI-2315883;
CC Q95QA6; G5EFL5: alp-1; NbExp=4; IntAct=EBI-327642, EBI-316352;
CC Q95QA6; O18302: gopc-1; NbExp=3; IntAct=EBI-327642, EBI-312747;
CC Q95QA6; G5EC32: sorb-1; NbExp=13; IntAct=EBI-327642, EBI-325337;
CC Q95QA6; G5ECG0: tac-1; NbExp=3; IntAct=EBI-327642, EBI-320612;
CC -!- SUBCELLULAR LOCATION: [Isoform a]: Apical cell membrane
CC {ECO:0000269|PubMed:21130760}; Peripheral membrane protein
CC {ECO:0000303|PubMed:21130760}. Basal cell membrane
CC {ECO:0000269|PubMed:21130760}; Peripheral membrane protein
CC {ECO:0000303|PubMed:21130760}. Cytoplasm {ECO:0000269|PubMed:21130760}.
CC Cell junction, hemidesmosome {ECO:0000269|PubMed:21130760}.
CC Note=Co=localizes with cytoplasmic intermediate filaments.
CC {ECO:0000269|PubMed:21130760}.
CC -!- SUBCELLULAR LOCATION: [Isoform e]: Cell membrane
CC {ECO:0000269|PubMed:21130760}.
CC -!- SUBCELLULAR LOCATION: [Isoform f]: Cell membrane
CC {ECO:0000269|PubMed:21130760}.
CC -!- SUBCELLULAR LOCATION: [Isoform i]: Cell membrane
CC {ECO:0000269|PubMed:21130760}.
CC -!- SUBCELLULAR LOCATION: [Isoform j]: Basal cell membrane
CC {ECO:0000269|PubMed:21130760}. Apical cell membrane
CC {ECO:0000269|PubMed:21130760}. Cytoplasm {ECO:0000269|PubMed:21130760}.
CC Cell junction, hemidesmosome {ECO:0000269|PubMed:21130760}.
CC -!- SUBCELLULAR LOCATION: [Isoform k]: Cell junction, hemidesmosome
CC {ECO:0000269|PubMed:21130760}. Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:21130760}. Note=Co-localizes with actin.
CC {ECO:0000269|PubMed:21130760}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=12;
CC Name=a {ECO:0000312|WormBase:T17H7.4a};
CC IsoId=Q95QA6-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:T17H7.4b};
CC IsoId=Q95QA6-2; Sequence=VSP_058357;
CC Name=c {ECO:0000312|WormBase:T17H7.4c};
CC IsoId=Q95QA6-3; Sequence=VSP_058360;
CC Name=d {ECO:0000312|WormBase:T17H7.4d};
CC IsoId=Q95QA6-4; Sequence=VSP_058356;
CC Name=e {ECO:0000312|WormBase:T17H7.4e};
CC IsoId=Q95QA6-5; Sequence=VSP_058353, VSP_058359, VSP_058361;
CC Name=f {ECO:0000312|WormBase:T17H7.4f};
CC IsoId=Q95QA6-6; Sequence=VSP_058351, VSP_058361;
CC Name=g {ECO:0000312|WormBase:T17H7.4g};
CC IsoId=Q95QA6-7; Sequence=VSP_058352, VSP_058359;
CC Name=h {ECO:0000312|WormBase:T17H7.4h};
CC IsoId=Q95QA6-8; Sequence=VSP_058353, VSP_058358, VSP_058361;
CC Name=i {ECO:0000312|WormBase:T17H7.4i};
CC IsoId=Q95QA6-9; Sequence=VSP_058353, VSP_058357, VSP_058361;
CC Name=j {ECO:0000312|WormBase:T17H7.4j};
CC IsoId=Q95QA6-10; Sequence=VSP_058355;
CC Name=k {ECO:0000312|WormBase:T17H7.4k};
CC IsoId=Q95QA6-11; Sequence=VSP_058354;
CC Name=l {ECO:0000312|WormBase:T17H7.4l};
CC IsoId=Q95QA6-12; Sequence=VSP_058351, VSP_058362;
CC -!- TISSUE SPECIFICITY: Isoform a: Expressed in the uterus, the vulva, the
CC rectum, mechanosensory neurons and in head and tail neurons. Isoform e:
CC Expressed in spermatheca and weakly in the vulva. Isoform f: Expressed
CC in spermatheca and weakly in the vulva. Isoform i: Expressed in
CC spermatheca and weakly in the vulva. {ECO:0000269|PubMed:21130760}.
CC -!- DEVELOPMENTAL STAGE: Isoform a: Expressed in dorso-ventral epidermal
CC cells from the comma stage of embryonic development to adulthood.
CC Isoform j: Expressed in the pharynx and head neurons from the 3-fold
CC stage of embryonic development to adulthood. Isoform k: Expressed in
CC dorso-ventral epidermal cells, the uterus, the vulva, the rectum and in
CC head and tail neurons from the 3-fold stage of embryonic development to
CC adulthood. Specifically expressed in seam cells at the 3-fold stage.
CC {ECO:0000269|PubMed:21130760}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethal with failed embryonic
CC morphogenesis. Disrupted intracellular structural integrity from the 2-
CC fold stage of embryogenesis resulting in thickening of the epidermis,
CC abnormal intermediate filament distribution and detachment and collapse
CC of muscle from the cell body, particularly in the head, tail and
CC midbody. RNAi-mediated knockdown results in developmental defects
CC whereby 95% embryos do not undergo morphogenesis and arrest before the
CC two-fold stage with abnormal head and tail structures and reduced
CC motility within the eggshell. Lethality in 40% of mutants (that survive
CC RNAi-mediated knockdown) by the adult molting phase of development,
CC with the remaining mutants displaying molting defects and paralysis.
CC {ECO:0000269|PubMed:21130760}.
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DR EMBL; BX284603; CCD65367.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65368.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65369.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65370.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65371.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65372.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65373.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65374.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65375.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65376.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65377.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD65378.1; -; Genomic_DNA.
DR RefSeq; NP_001022769.1; NM_001027598.2.
DR RefSeq; NP_497244.1; NM_064843.4.
DR RefSeq; NP_497245.1; NM_064844.3.
DR RefSeq; NP_497246.1; NM_064845.3.
DR RefSeq; NP_497247.2; NM_064846.3.
DR RefSeq; NP_497248.2; NM_064847.2.
DR RefSeq; NP_741076.1; NM_171067.3. [Q95QA6-10]
DR RefSeq; NP_741077.1; NM_171068.3. [Q95QA6-11]
DR RefSeq; NP_741078.1; NM_171069.1.
DR RefSeq; NP_741079.1; NM_171859.1.
DR RefSeq; NP_741080.1; NM_171070.4.
DR RefSeq; NP_741081.1; NM_171071.3.
DR AlphaFoldDB; Q95QA6; -.
DR SMR; Q95QA6; -.
DR DIP; DIP-27452N; -.
DR IntAct; Q95QA6; 99.
DR EPD; Q95QA6; -.
DR PeptideAtlas; Q95QA6; -.
DR PRIDE; Q95QA6; -.
DR EnsemblMetazoa; T17H7.4a.1; T17H7.4a.1; WBGene00003936. [Q95QA6-1]
DR EnsemblMetazoa; T17H7.4b.1; T17H7.4b.1; WBGene00003936. [Q95QA6-2]
DR EnsemblMetazoa; T17H7.4c.1; T17H7.4c.1; WBGene00003936. [Q95QA6-3]
DR EnsemblMetazoa; T17H7.4d.1; T17H7.4d.1; WBGene00003936. [Q95QA6-4]
DR EnsemblMetazoa; T17H7.4d.2; T17H7.4d.2; WBGene00003936. [Q95QA6-4]
DR EnsemblMetazoa; T17H7.4d.3; T17H7.4d.3; WBGene00003936. [Q95QA6-4]
DR EnsemblMetazoa; T17H7.4d.4; T17H7.4d.4; WBGene00003936. [Q95QA6-4]
DR EnsemblMetazoa; T17H7.4d.5; T17H7.4d.5; WBGene00003936. [Q95QA6-4]
DR EnsemblMetazoa; T17H7.4d.6; T17H7.4d.6; WBGene00003936. [Q95QA6-4]
DR EnsemblMetazoa; T17H7.4d.7; T17H7.4d.7; WBGene00003936. [Q95QA6-4]
DR EnsemblMetazoa; T17H7.4e.1; T17H7.4e.1; WBGene00003936. [Q95QA6-5]
DR EnsemblMetazoa; T17H7.4g.1; T17H7.4g.1; WBGene00003936. [Q95QA6-7]
DR EnsemblMetazoa; T17H7.4g.2; T17H7.4g.2; WBGene00003936. [Q95QA6-7]
DR EnsemblMetazoa; T17H7.4h.1; T17H7.4h.1; WBGene00003936. [Q95QA6-8]
DR EnsemblMetazoa; T17H7.4i.1; T17H7.4i.1; WBGene00003936. [Q95QA6-9]
DR EnsemblMetazoa; T17H7.4j.1; T17H7.4j.1; WBGene00003936. [Q95QA6-10]
DR EnsemblMetazoa; T17H7.4k.1; T17H7.4k.1; WBGene00003936. [Q95QA6-11]
DR EnsemblMetazoa; T17H7.4k.2; T17H7.4k.2; WBGene00003936. [Q95QA6-11]
DR GeneID; 175227; -.
DR KEGG; cel:CELE_T17H7.4; -.
DR UCSC; T17H7.4g.1; c. elegans.
DR CTD; 175227; -.
DR WormBase; T17H7.4a; CE28670; WBGene00003936; pat-12. [Q95QA6-1]
DR WormBase; T17H7.4b; CE28671; WBGene00003936; pat-12. [Q95QA6-2]
DR WormBase; T17H7.4c; CE28672; WBGene00003936; pat-12. [Q95QA6-3]
DR WormBase; T17H7.4d; CE35016; WBGene00003936; pat-12. [Q95QA6-4]
DR WormBase; T17H7.4e; CE31612; WBGene00003936; pat-12. [Q95QA6-5]
DR WormBase; T17H7.4f; CE31613; WBGene00003936; pat-12. [Q95QA6-6]
DR WormBase; T17H7.4g; CE31614; WBGene00003936; pat-12. [Q95QA6-7]
DR WormBase; T17H7.4h; CE31615; WBGene00003936; pat-12. [Q95QA6-8]
DR WormBase; T17H7.4i; CE31616; WBGene00003936; pat-12. [Q95QA6-9]
DR WormBase; T17H7.4j; CE31617; WBGene00003936; pat-12. [Q95QA6-10]
DR WormBase; T17H7.4k; CE31618; WBGene00003936; pat-12. [Q95QA6-11]
DR WormBase; T17H7.4l; CE33939; WBGene00003936; pat-12. [Q95QA6-12]
DR OMA; NRTENDR; -.
DR OrthoDB; 1656370at2759; -.
DR SignaLink; Q95QA6; -.
DR PRO; PR:Q95QA6; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003936; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; Q95QA6; baseline and differential.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009925; C:basal plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0030056; C:hemidesmosome; IDA:WormBase.
DR GO; GO:0048598; P:embryonic morphogenesis; IMP:WormBase.
DR GO; GO:0031581; P:hemidesmosome assembly; IMP:WormBase.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell junction; Cell membrane; Cytoplasm;
KW Cytoskeleton; Membrane; Reference proteome.
FT CHAIN 1..663
FT /note="Protein pat-12"
FT /evidence="ECO:0000305"
FT /id="PRO_0000436363"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..399
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..641
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..330
FT /note="Missing (in isoform f and isoform l)"
FT /evidence="ECO:0000305"
FT /id="VSP_058351"
FT VAR_SEQ 1..257
FT /note="Missing (in isoform g)"
FT /evidence="ECO:0000305"
FT /id="VSP_058352"
FT VAR_SEQ 1..213
FT /note="MTSHIATETSVNRWSTEPVVREEGRPPGPEDFPSTKQGREQDGNVIGITPNY
FT KIGEQKPNSELNLGKTGSLPRGSGDYKMTYRQEDYKQTIIDPKVITNANMPYISTRIPD
FT PRRNLAGDFPSEHSKSKIKLDPLEQRRFRSSESRPITTSNYLAESVDRHREMEASRLRE
FT YLKAKENEANQPWNKPGWPGPKKNDESLRELETMKQRIETLKR -> MRQGGIYQTK
FT (in isoform e, isoform h and isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_058353"
FT VAR_SEQ 1..29
FT /note="MTSHIATETSVNRWSTEPVVREEGRPPGP -> MVEIYKPPQKRISSQLMQK
FT LQLF (in isoform k)"
FT /evidence="ECO:0000305"
FT /id="VSP_058354"
FT VAR_SEQ 1
FT /note="M -> MEKEKEEKDGTKDAKKDEEEPSVKVFIRPLEVTVPADFLFQKPEKAQ
FT KTYWSTM (in isoform j)"
FT /evidence="ECO:0000305"
FT /id="VSP_058355"
FT VAR_SEQ 2..663
FT /note="TSHIATETSVNRWSTEPVVREEGRPPGPEDFPSTKQGREQDGNVIGITPNYK
FT IGEQKPNSELNLGKTGSLPRGSGDYKMTYRQEDYKQTIIDPKVITNANMPYISTRIPDP
FT RRNLAGDFPSEHSKSKIKLDPLEQRRFRSSESRPITTSNYLAESVDRHREMEASRLREY
FT LKAKENEANQPWNKPGWPGPKKNDESLRELETMKQRIETLKRDANKGPVNAELDELSKR
FT AEELRKRDGWSKYKLVESDIYKTDPDPMPANIKDQVRDLLESRNSVETTTTQRDHDKSG
FT YVTDVSTATWNFSTVDYSPRSVVSMNGASHDILKDDKPRSIMKRNDLVRREQMLYPTVD
FT TQVVKSVVKKPTVTETVQRFEETRRTEEVERRVQRREKKERRSRHHSSSRHHSGWEGHT
FT GGYQGHRSSSLSRGGHGGGGQETYYRQETTRRQQHNNYDDNFNRGIAHARYGSLSDSLR
FT RGELQYVPNGEVRQSFYRDGSNGGQRMHKSYSTRDVFTGDGYDDRRSVSSFRRGSQQQV
FT SPFVEFPPTLPRRGGGGDYRREEDAYFRPVSKSRSYADWDDAGRAGMGREVRRYDDDMS
FT RLEAEFRDSLLMPMPAGNMNERDHRTEQLPGGYETFNKERHANSGRRSGRDGKPVDFNE
FT ATQEYNYKREQTLNDDRRRR -> SFQQPQASPISPGDSGWLIKMRKNRYLDHTSKVNE
FT PKKYRSMDQLPTGKVGAPDNEKSEGTDPLHWQLRKDFHLAKYSERRASYHVESSSYIHS
FT SQQIQHPPQQHHPPPPSPPPVAETIQHQPHPSQQQPSTTTISSRQLYKSQLLYPPGSTE
FT NIASEHKPAIRPPEKSVYENNPIAPSELNVQVKRAPPQGPPPPPPPQAPADIDYPERLM
FT SPPPTHQPRSILKGYSSQQYYSQTNLTESHHHQSSQETSLNPQQMHPRPSDRRTPTHFE
FT DLSEDEKTRIMHENLQRHRNMRSGPNGPRPTTTSFNGPFFRLEQVNPGQNQPQQPQYQQ
FT HPRSQSVDPSGDMNGGPRPIHQNFSASEIELHHYSRNAEPSVVVWPPVSEKERERPSSV
FT LAKNFNDPERIDEYQRQKRLEYEAIQRTNEKQAVSMAKQVNAMMQQQKLYERSHGMTSP
FT VPIMESISPQPQVSHHHHQPQQHQQHQPQQQYYPSPPPPPQPYRDPEPVFNPVQVYETR
FT PISALSDQIDQPPSQQAPTSWKRTYIVERPRDVAKNEIITSDQLLEKEAYDVDLLKRRE
FT TFVEKPEEAPRINRLGRRWQPPPERPYVWPTLRRAMSVEPSSMPVDFAPGVPHNYDDNE
FT EYKWEPVVNDPGYKKEDKNFTPVNSPPASPRRGHGVGPLDEPARRQAKYVIQPSPDGSH
FT RPKAVFRKERHAPSGGFYPHAPNAIKVVKKRAQSVQGLLSPTDNVEVIHQRNYHRLDLE
FT QNGHHGQKLRRSQHGGSEMDLRRSTQEMPDWEKIYELPPHSSQIVQKDMPRHVDVQRRL
FT SKFEGSIQNLRAATSTQHLDSMQQLHFPMPDYEPPQPPQQRRRTESSGYRGGPPPPPPM
FT PQQQPREMSRRNSVASTRIDSPSLMIPHHRQSRSDSRGPPQMSRAASSIPLSPQPTPQH
FT HHHHHSQRPTTPGATRARNYIARATAPSPTPYSYDRARAYVPPALPPGYRLADPIPDQR
FT AMSPSPGHTRKLIRNVSESAQRLHPSGSTPQTSRAPSRHSHRQSPNPRFL (in
FT isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_058356"
FT VAR_SEQ 221..323
FT /note="NAELDELSKRAEELRKRDGWSKYKLVESDIYKTDPDPMPANIKDQVRDLLES
FT RNSVETTTTQRDHDKSGYVTDVSTATWNFSTVDYSPRSVVSMNGASHDILK -> TVPP
FT LRTKTPPPPPPPVRRHEIYEQHKRYTSAPNLQSAVIRIQ (in isoform b and
FT isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_058357"
FT VAR_SEQ 221..323
FT /note="Missing (in isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_058358"
FT VAR_SEQ 293..323
FT /note="Missing (in isoform e and isoform g)"
FT /evidence="ECO:0000305"
FT /id="VSP_058359"
FT VAR_SEQ 323
FT /note="K -> KTVPPLRTKTPPPPPPPVRRHEIYEQHKRYTSAPNLQSAVIRIQ
FT (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_058360"
FT VAR_SEQ 412
FT /note="G -> EYRQGAITSSLPRRQIIREADRAMTEEEMNKVVREAYAAADEARKDS
FT R (in isoform e, isoform f, isoform h and isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_058361"
FT VAR_SEQ 412
FT /note="G -> EYRQGAITSSLPRRQIIREADRAMTEEEMNKVVREAYAAADEARKDS
FT RTSSLLFLGFLIFVC (in isoform l)"
FT /evidence="ECO:0000305"
FT /id="VSP_058362"
SQ SEQUENCE 663 AA; 76709 MW; 416F3943DB9A7ACA CRC64;
MTSHIATETS VNRWSTEPVV REEGRPPGPE DFPSTKQGRE QDGNVIGITP NYKIGEQKPN
SELNLGKTGS LPRGSGDYKM TYRQEDYKQT IIDPKVITNA NMPYISTRIP DPRRNLAGDF
PSEHSKSKIK LDPLEQRRFR SSESRPITTS NYLAESVDRH REMEASRLRE YLKAKENEAN
QPWNKPGWPG PKKNDESLRE LETMKQRIET LKRDANKGPV NAELDELSKR AEELRKRDGW
SKYKLVESDI YKTDPDPMPA NIKDQVRDLL ESRNSVETTT TQRDHDKSGY VTDVSTATWN
FSTVDYSPRS VVSMNGASHD ILKDDKPRSI MKRNDLVRRE QMLYPTVDTQ VVKSVVKKPT
VTETVQRFEE TRRTEEVERR VQRREKKERR SRHHSSSRHH SGWEGHTGGY QGHRSSSLSR
GGHGGGGQET YYRQETTRRQ QHNNYDDNFN RGIAHARYGS LSDSLRRGEL QYVPNGEVRQ
SFYRDGSNGG QRMHKSYSTR DVFTGDGYDD RRSVSSFRRG SQQQVSPFVE FPPTLPRRGG
GGDYRREEDA YFRPVSKSRS YADWDDAGRA GMGREVRRYD DDMSRLEAEF RDSLLMPMPA
GNMNERDHRT EQLPGGYETF NKERHANSGR RSGRDGKPVD FNEATQEYNY KREQTLNDDR
RRR
