PAT14_MOUSE
ID PAT14_MOUSE Reviewed; 99 AA.
AC Q3UN54;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Prostate and testis expressed protein 14 {ECO:0000303|PubMed:27098205};
DE AltName: Full=Secreted seminal-vesicle Ly-6 protein 1 {ECO:0000303|PubMed:16940290};
DE Short=SSLP-1 {ECO:0000303|PubMed:16940290};
DE Flags: Precursor;
GN Name=Pate14 {ECO:0000303|PubMed:27098205};
GN Synonyms=Sslp1 {ECO:0000303|PubMed:16940290};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAE25893.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE25893.1}; TISSUE=Seminal vesicle;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PROTEIN SEQUENCE OF 22-36, SUBUNIT, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, AND GLYCOSYLATION.
RC TISSUE=Seminal vesicle;
RX PubMed=16940290; DOI=10.1530/rep.1.01183;
RA Li S.-H., Lee R.K.-K., Lin M.-H., Hwu Y.-M., Lu C.-H., Chen Y.-J.,
RA Chen H.-C., Chang W.-H., Chang W.-C.;
RT "SSLP-1, a secreted Ly-6 protein purified from mouse seminal vesicle
RT fluid.";
RL Reproduction 132:493-500(2006).
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=21942998; DOI=10.1186/1477-7827-9-128;
RA Turunen H.T., Sipilae P., Pujianto D.A., Damdimopoulos A.E., Bjoerkgren I.,
RA Huhtaniemi I., Poutanen M.;
RT "Members of the murine Pate family are predominantly expressed in the
RT epididymis in a segment-specific fashion and regulated by androgens and
RT other testicular factors.";
RL Reprod. Biol. Endocrinol. 9:128-128(2011).
RN [4] {ECO:0000305}
RP NOMENCLATURE.
RX PubMed=27098205; DOI=10.1186/s40246-016-0074-2;
RA Loughner C.L., Bruford E.A., McAndrews M.S., Delp E.E., Swamynathan S.,
RA Swamynathan S.K.;
RT "Organization, evolution and functions of the human and mouse Ly6/uPAR
RT family genes.";
RL Hum. Genomics 10:10-10(2016).
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:16940290}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16940290}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in the seminal vesicles
CC (PubMed:16940290). Expressed in prostate, and to a lesser extent in the
CC cauda epididymis (PubMed:21942998). {ECO:0000269|PubMed:16940290,
CC ECO:0000269|PubMed:21942998}.
CC -!- DEVELOPMENTAL STAGE: Expressed from 3 weeks onwards.
CC {ECO:0000269|PubMed:16940290}.
CC -!- INDUCTION: By testosterone. {ECO:0000269|PubMed:16940290}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:16940290}.
CC -!- SIMILARITY: Belongs to the PATE family. {ECO:0000305}.
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DR EMBL; AK144443; BAE25893.1; -; mRNA.
DR CCDS; CCDS22970.1; -.
DR RefSeq; NP_001028497.1; NM_001033325.2.
DR AlphaFoldDB; Q3UN54; -.
DR SMR; Q3UN54; -.
DR STRING; 10090.ENSMUSP00000091391; -.
DR GlyGen; Q3UN54; 2 sites.
DR PaxDb; Q3UN54; -.
DR PRIDE; Q3UN54; -.
DR ProteomicsDB; 257076; -.
DR Ensembl; ENSMUST00000093868; ENSMUSP00000091391; ENSMUSG00000070313.
DR GeneID; 235973; -.
DR KEGG; mmu:235973; -.
DR UCSC; uc009otr.1; mouse.
DR CTD; 235973; -.
DR MGI; MGI:3055869; Pate14.
DR VEuPathDB; HostDB:ENSMUSG00000070313; -.
DR eggNOG; ENOG502TDW1; Eukaryota.
DR GeneTree; ENSGT00940000163158; -.
DR HOGENOM; CLU_178161_0_0_1; -.
DR InParanoid; Q3UN54; -.
DR OMA; FLQALQC; -.
DR OrthoDB; 1575740at2759; -.
DR PhylomeDB; Q3UN54; -.
DR TreeFam; TF337781; -.
DR BioGRID-ORCS; 235973; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Pate14; mouse.
DR PRO; PR:Q3UN54; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q3UN54; protein.
DR Bgee; ENSMUSG00000070313; Expressed in primary oocyte and 9 other tissues.
DR ExpressionAtlas; Q3UN54; baseline and differential.
DR Genevisible; Q3UN54; MM.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:16940290"
FT CHAIN 22..99
FT /note="Prostate and testis expressed protein 14"
FT /evidence="ECO:0000269|PubMed:16940290"
FT /id="PRO_0000238926"
FT DOMAIN 22..99
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000305"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 24..51
FT /evidence="ECO:0000255"
FT DISULFID 27..36
FT /evidence="ECO:0000255"
FT DISULFID 43..69
FT /evidence="ECO:0000255"
FT DISULFID 73..89
FT /evidence="ECO:0000255"
FT DISULFID 90..96
FT /evidence="ECO:0000255"
SQ SEQUENCE 99 AA; 11155 MW; 1A1246026AE63D5F CRC64;
MEKYLLLLLL GIFLRVGFLQ ALTCVSCGRL NSSGICETAE TSCEATNNRK CALRLLYKDG
KFQYGFQGCL GTCFNYTKTN NNMVKEHKCC DHQNLCNKP
