ID   PAT1_SCHPO              Reviewed;         754 AA.
AC   O42958;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=DNA topoisomerase 2-associated protein pat1;
DE   AltName: Full=Decapping activator and translational repressor pat1;
DE   AltName: Full=Topoisomerase II-associated protein pat1;
GN   ORFNames=SPBC19G7.10c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Activator of decapping that functions as a general and active
CC       mechanism of translational repression and required for P-body
CC       formation. Stabilizes the 3' terminus of mRNAs and modulates the rates
CC       of mRNA-decapping that occur following deadenylation. Might be required
CC       for promoting the formation or the stabilization of the preinitiation
CC       translation complexes. Necessary for accurate chromosome transmission
CC       during cell division (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC       Cytoplasm, P-body {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the PAT1 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA17064.2; -; Genomic_DNA.
DR   PIR; T39841; T39841.
DR   RefSeq; NP_595976.2; NM_001021884.3.
DR   AlphaFoldDB; O42958; -.
DR   SMR; O42958; -.
DR   BioGRID; 277297; 25.
DR   STRING; 4896.SPBC19G7.10c.1; -.
DR   iPTMnet; O42958; -.
DR   MaxQB; O42958; -.
DR   PaxDb; O42958; -.
DR   EnsemblFungi; SPBC19G7.10c.1; SPBC19G7.10c.1:pep; SPBC19G7.10c.
DR   GeneID; 2540778; -.
DR   KEGG; spo:SPBC19G7.10c; -.
DR   PomBase; SPBC19G7.10c; -.
DR   VEuPathDB; FungiDB:SPBC19G7.10c; -.
DR   eggNOG; KOG4592; Eukaryota.
DR   HOGENOM; CLU_012622_1_0_1; -.
DR   InParanoid; O42958; -.
DR   OMA; DFITRYQ; -.
DR   PhylomeDB; O42958; -.
DR   Reactome; R-SPO-430039; mRNA decay by 5' to 3' exoribonuclease.
DR   PRO; PR:O42958; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0000932; C:P-body; IPI:PomBase.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IDA:PomBase.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR   InterPro; IPR039900; Pat1-like.
DR   InterPro; IPR019167; PAT1_dom.
DR   PANTHER; PTHR21551; PTHR21551; 1.
DR   Pfam; PF09770; PAT1; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; Reference proteome; Repressor; RNA-binding;
KW   Translation regulation.
FT   CHAIN           1..754
FT                   /note="DNA topoisomerase 2-associated protein pat1"
FT                   /id="PRO_0000372628"
SQ   SEQUENCE   754 AA;  84117 MW;  EB226989F3D8E53A CRC64;
     MSFFGFNTTL PKENMFPNEG QLEEDGIDFE ETYDDLGNQL NEAGDELNDE TFGVSAGSIG
     RDFDFSGTTA QASAQLEDEQ YQINQQNIFA KPVKPASSEL PQVSRLNGAS QFPSREPAST
     AINKLSDLQP MASIWENIVP EKPAIIPPEV ASLQDRLGAQ PSEKVFSLQE LEEQLLNSMT
     APKPPSQPAI PIVPSEMAAQ VTRENISSLD PAISAASIGN VTFGQPNIPS TTTDFAGLAA
     PNMVHPSQAI PNPVMQPSLV PQMPYPQNGM YNPSVAPPAS LVNLFQQEQL IQNQNLDEKR
     QKLERDHMLM AQCAGLMTRS DKSFIARIQI SQLMSEDPES DDFYYRVYSI IRGRKPSEEE
     ASHFIQTYLG PSNNRRRGRR SENPMQKLQQ QLQRLVSSAK ERPKATQLSL EGALGKIAVN
     TVRTPRQLLN VKRPTEPASS NSSLNNFSGF STKKDVLHAI EKVYDLLLDF EQALRKASTL
     ETTDQEQIDT WKTTLSEKLE SIWKALYINE SLEASSKTRP PFISIISHPK GMRLLPRLFP
     HLSKEQQISI LKVVVYNFDS LDIVLRGTFD VNGELPLDVV SEMSSFTQFI IPPLLTIVNE
     LDLETINNLF SQLLNRTNAV YLIQTKIGLS FLTLFISRAE ILKQSGTVNQ NEKEEWENTF
     NVMFNRVKGH FSTVFPPPNA RAYADESYPW EFLAACATAA SSEQHFTLVS ETRDRVLDNI
     ITSKRAPSEI AVVRISNVNL FLNAMGLDAR QLSA