ID   PATA_NOSS1              Reviewed;         379 AA.
AC   P39048;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Protein PatA;
DE   AltName: Full=PAT-1;
GN   Name=patA; OrderedLocusNames=all0521;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RX   PubMed=1608976; DOI=10.1073/pnas.89.12.5655;
RA   Liang J.-J., Scappino L., Haselkorn R.;
RT   "The patA gene product, which contains a region similar to CheY of
RT   Escherichia coli, controls heterocyst pattern formation in the
RT   cyanobacterium Anabaena 7120.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:5655-5659(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11237320; DOI=10.1006/abio.2000.4979;
RA   Cai Y.A., Murphy J.T., Wedemayer G.J., Glazer A.N.;
RT   "Recombinant phycobiliproteins. Recombinant C-phycocyanins equipped with
RT   affinity tags, oligomerization, and biospecific recognition domains.";
RL   Anal. Biochem. 290:186-204(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=20622060; DOI=10.1128/jb.00577-10;
RA   Young-Robbins S.S., Risser D.D., Moran J.R., Haselkorn R., Callahan S.M.;
RT   "Transcriptional regulation of the heterocyst patterning gene patA from
RT   Anabaena sp. strain PCC 7120.";
RL   J. Bacteriol. 192:4732-4740(2010).
RN   [5]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=20639317; DOI=10.1128/jb.00640-10;
RA   Bastet L., Boileau C., Bedu S., Janicki A., Latifi A., Zhang C.C.;
RT   "NtcA regulates patA expression in Anabaena sp. strain PCC 7120.";
RL   J. Bacteriol. 192:5257-5259(2010).
CC   -!- FUNCTION: Controls heterocyst pattern formation. Required for the
CC       differentiation of intercalary heterocysts but not for terminal
CC       heterocysts. {ECO:0000269|PubMed:1608976, ECO:0000269|PubMed:20622060,
CC       ECO:0000269|PubMed:20639317}.
CC   -!- SUBCELLULAR LOCATION: Cell septum {ECO:0000269|PubMed:20622060}.
CC       Note=Localizes at sites of cell division.
CC   -!- INDUCTION: By nitrogen starvation. Induction requires HetR.
CC       Transcription positively regulated by NtcA.
CC       {ECO:0000269|PubMed:1608976, ECO:0000269|PubMed:20622060,
CC       ECO:0000269|PubMed:20639317}.
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DR   EMBL; M87501; AAB59012.1; -; Genomic_DNA.
DR   EMBL; AF178757; AAG09314.1; -; Genomic_DNA.
DR   EMBL; BA000019; BAB72479.1; -; Genomic_DNA.
DR   PIR; A45267; A45267.
DR   PIR; AH1871; AH1871.
DR   AlphaFoldDB; P39048; -.
DR   SMR; P39048; -.
DR   IntAct; P39048; 7.
DR   STRING; 103690.17129866; -.
DR   EnsemblBacteria; BAB72479; BAB72479; BAB72479.
DR   KEGG; ana:all0521; -.
DR   eggNOG; COG0784; Bacteria.
DR   OMA; PDYLAIC; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0030428; C:cell septum; IDA:UniProtKB.
DR   GO; GO:0006995; P:cellular response to nitrogen starvation; IDA:UniProtKB.
DR   GO; GO:0043158; P:heterocyst differentiation; IDA:UniProtKB.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR025497; DUF4388.
DR   InterPro; IPR024186; Sig_transdc_resp-reg_PatA.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF14332; DUF4388; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PIRSF; PIRSF005897; RR_PatA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   2: Evidence at transcript level;
KW   Heterocyst; Phosphoprotein; Reference proteome;
KW   Two-component regulatory system.
FT   CHAIN           1..379
FT                   /note="Protein PatA"
FT                   /id="PRO_0000081182"
FT   DOMAIN          262..378
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   REGION          181..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         313
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   379 AA;  43205 MW;  4505763B17BE2BF7 CRC64;
     MKTLPITRYR FFQKIQPLSL LKKITGKTIT GCLQVFSTSG TWSIYVEEGK LIYACYSERM
     FEPLYRHLGN LSPQIATLPK EINEQLRAIF ETGIENQAIP NPDYLAICWL VNQKYISSSQ
     AAVLIEQLAL EVVESFLMLE EGSYEFIPES FLDDLPKFCY LNVRLLVEQC QQHGRVPEAF
     RREASSQEIS SSTEHNQIPV NNRRSTKFTS PPHTQPKPEP RLPQINTNKS TEYSKRYASQ
     PNTVNHGYSQ TSATSTDKKI YTIFCIDENP IVLNNIKNFL DDQIFAVIGV TDSLKALMEI
     LCTKPDIILI NVDMPDLDGY ELCSLLRKHS YFKNTPVIMV TEKAGLVDRA RAKIVRASGH
     LTKPFNQGDL LKVIFKHIT