ID   PATE1_HUMAN             Reviewed;         126 AA.
AC   Q8WXA2; Q3KNX2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Prostate and testis expressed protein 1;
DE   Flags: Precursor;
GN   Name=PATE1; Synonyms=PATE;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX   PubMed=11880645; DOI=10.1073/pnas.052713699;
RA   Bera T.K., Maitra R., Iavarone C., Salvatore G., Kumar V., Vincent J.J.,
RA   Sathyanarayana B.K., Duray P., Lee B.K., Pastan I.;
RT   "PATE, a gene expressed in prostate cancer, normal prostate, and testis,
RT   identified by a functional genomic approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:3058-3063(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   ARG-47.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8WXA2; Q0VD86: INCA1; NbExp=3; IntAct=EBI-10277790, EBI-6509505;
CC       Q8WXA2; Q04864: REL; NbExp=3; IntAct=EBI-10277790, EBI-307352;
CC       Q8WXA2; Q53GC0: SERTAD1; NbExp=3; IntAct=EBI-10277790, EBI-2826300;
CC       Q8WXA2; P15884: TCF4; NbExp=3; IntAct=EBI-10277790, EBI-533224;
CC       Q8WXA2-2; P15884-3: TCF4; NbExp=3; IntAct=EBI-12837654, EBI-13636688;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8WXA2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8WXA2-2; Sequence=VSP_030533;
CC   -!- TISSUE SPECIFICITY: Expressed specifically in prostate cancer, normal
CC       prostate, and testis. Expressed in the epithelial cells of the prostate
CC       cancer and normal prostate tissues. {ECO:0000269|PubMed:11880645}.
CC   -!- SIMILARITY: Belongs to the PATE family. {ECO:0000305}.
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DR   EMBL; AF462605; AAL68667.1; -; mRNA.
DR   EMBL; CH471065; EAW67661.1; -; Genomic_DNA.
DR   EMBL; BC039863; AAH39863.1; -; mRNA.
DR   EMBL; BC107044; AAI07045.1; -; mRNA.
DR   CCDS; CCDS8464.1; -. [Q8WXA2-1]
DR   RefSeq; NP_612151.1; NM_138294.2. [Q8WXA2-1]
DR   AlphaFoldDB; Q8WXA2; -.
DR   SMR; Q8WXA2; -.
DR   BioGRID; 127747; 115.
DR   IntAct; Q8WXA2; 5.
DR   STRING; 9606.ENSP00000307164; -.
DR   iPTMnet; Q8WXA2; -.
DR   PhosphoSitePlus; Q8WXA2; -.
DR   BioMuta; PATE1; -.
DR   DMDM; 74730987; -.
DR   MassIVE; Q8WXA2; -.
DR   PaxDb; Q8WXA2; -.
DR   PeptideAtlas; Q8WXA2; -.
DR   PRIDE; Q8WXA2; -.
DR   ProteomicsDB; 74992; -. [Q8WXA2-1]
DR   ProteomicsDB; 74993; -. [Q8WXA2-2]
DR   Antibodypedia; 67054; 59 antibodies from 14 providers.
DR   DNASU; 160065; -.
DR   Ensembl; ENST00000305738.10; ENSP00000307164.4; ENSG00000171053.10. [Q8WXA2-1]
DR   Ensembl; ENST00000437148.2; ENSP00000396056.2; ENSG00000171053.10. [Q8WXA2-2]
DR   GeneID; 160065; -.
DR   KEGG; hsa:160065; -.
DR   MANE-Select; ENST00000305738.10; ENSP00000307164.4; NM_138294.3; NP_612151.1.
DR   UCSC; uc001qct.4; human. [Q8WXA2-1]
DR   CTD; 160065; -.
DR   DisGeNET; 160065; -.
DR   GeneCards; PATE1; -.
DR   HGNC; HGNC:24664; PATE1.
DR   HPA; ENSG00000171053; Tissue enriched (epididymis).
DR   MIM; 606861; gene.
DR   neXtProt; NX_Q8WXA2; -.
DR   OpenTargets; ENSG00000171053; -.
DR   PharmGKB; PA164724368; -.
DR   VEuPathDB; HostDB:ENSG00000171053; -.
DR   eggNOG; ENOG502TDVG; Eukaryota.
DR   GeneTree; ENSGT00390000012586; -.
DR   HOGENOM; CLU_170458_0_0_1; -.
DR   InParanoid; Q8WXA2; -.
DR   OMA; CANVENI; -.
DR   OrthoDB; 1484334at2759; -.
DR   PhylomeDB; Q8WXA2; -.
DR   TreeFam; TF337781; -.
DR   PathwayCommons; Q8WXA2; -.
DR   SignaLink; Q8WXA2; -.
DR   BioGRID-ORCS; 160065; 5 hits in 1063 CRISPR screens.
DR   GenomeRNAi; 160065; -.
DR   Pharos; Q8WXA2; Tbio.
DR   PRO; PR:Q8WXA2; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8WXA2; protein.
DR   Bgee; ENSG00000171053; Expressed in corpus epididymis and 14 other tissues.
DR   Genevisible; Q8WXA2; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030548; F:acetylcholine receptor regulator activity; IEA:Ensembl.
DR   GO; GO:0099601; P:regulation of neurotransmitter receptor activity; IEA:Ensembl.
PE   1: Evidence at protein level;
KW   Alternative splicing; Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..126
FT                   /note="Prostate and testis expressed protein 1"
FT                   /id="PRO_0000315325"
FT   DOMAIN          46..125
FT                   /note="UPAR/Ly6"
FT                   /evidence="ECO:0000305"
FT   DISULFID        48..75
FT                   /evidence="ECO:0000255"
FT   DISULFID        51..60
FT                   /evidence="ECO:0000255"
FT   DISULFID        67..94
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..115
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         30..41
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_030533"
FT   VARIANT         46
FT                   /note="V -> I (in dbSNP:rs537916)"
FT                   /id="VAR_052699"
FT   VARIANT         47
FT                   /note="Q -> R (in dbSNP:rs2114084)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_052700"
SQ   SEQUENCE   126 AA;  14271 MW;  9AD752F00D901FFE CRC64;
     MDKSLLLELP ILLCCFRALS GSLSMRNDAV NEIVAVKNNF PVIEIVQCRM CHLQFPGEKC
     SRGRGICTAT TEEACMVGRM FKRDGNPWLT FMGCLKNCAD VKGIRWSVYL VNFRCCRSHD
     LCNEDL