PATE2_HUMAN
ID PATE2_HUMAN Reviewed; 113 AA.
AC Q6UY27; B2RNZ2; B7ZMG4;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Prostate and testis expressed protein 2;
DE AltName: Full=PATE-like protein M;
DE Short=PATE-M;
DE Flags: Precursor;
GN Name=PATE2; Synonyms=C11orf38; ORFNames=UNQ3112/PRO10144;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY, AND ALTERNATIVE SPLICING (ISOFORM 2).
RX PubMed=18387948; DOI=10.1074/jbc.m801454200;
RA Levitin F., Weiss M., Hahn Y., Stern O., Papke R.L., Matusik R.,
RA Nandana S.R., Ziv R., Pichinuk E., Salame S., Bera T., Vincent J., Lee B.,
RA Pastan I., Wreschner D.H.;
RT "PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that
RT are expressed in reproductive and neuron-rich tissues and possess
RT neuromodulatory activity.";
RL J. Biol. Chem. 283:16928-16939(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UY27-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UY27-2; Sequence=VSP_035810;
CC -!- TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in prostate
CC and testis. Isoform 2 is expressed in male and female brain at
CC equivalent levels, in particular in cerebellum, cerebral cortex, corpus
CC callosum, occipital, parrietal and temporal lobes, and pons, but not in
CC amygdala, cerebral peduncle, hippocampus and thalamus.
CC {ECO:0000269|PubMed:18387948}.
CC -!- SIMILARITY: Belongs to the PATE family. {ECO:0000305}.
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DR EMBL; AY358105; AAQ88472.1; -; mRNA.
DR EMBL; AP003087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW67663.1; -; Genomic_DNA.
DR EMBL; BC137190; AAI37191.1; -; mRNA.
DR EMBL; BC137193; AAI37194.1; -; mRNA.
DR EMBL; BC144526; AAI44527.1; -; mRNA.
DR CCDS; CCDS8465.1; -. [Q6UY27-1]
DR RefSeq; NP_997720.1; NM_212555.2. [Q6UY27-1]
DR AlphaFoldDB; Q6UY27; -.
DR SMR; Q6UY27; -.
DR BioGRID; 134470; 56.
DR STRING; 9606.ENSP00000351325; -.
DR iPTMnet; Q6UY27; -.
DR PhosphoSitePlus; Q6UY27; -.
DR BioMuta; PATE2; -.
DR DMDM; 74738311; -.
DR MassIVE; Q6UY27; -.
DR PaxDb; Q6UY27; -.
DR PeptideAtlas; Q6UY27; -.
DR PRIDE; Q6UY27; -.
DR ProteomicsDB; 67696; -. [Q6UY27-1]
DR ProteomicsDB; 67697; -. [Q6UY27-2]
DR DNASU; 399967; -.
DR Ensembl; ENST00000358524.8; ENSP00000351325.3; ENSG00000196844.9. [Q6UY27-1]
DR Ensembl; ENST00000436890.2; ENSP00000414895.2; ENSG00000196844.9. [Q6UY27-2]
DR GeneID; 399967; -.
DR KEGG; hsa:399967; -.
DR MANE-Select; ENST00000358524.8; ENSP00000351325.3; NM_212555.3; NP_997720.1.
DR UCSC; uc001qcu.5; human. [Q6UY27-1]
DR CTD; 399967; -.
DR GeneCards; PATE2; -.
DR HGNC; HGNC:32249; PATE2.
DR HPA; ENSG00000196844; Tissue enriched (epididymis).
DR neXtProt; NX_Q6UY27; -.
DR OpenTargets; ENSG00000196844; -.
DR PharmGKB; PA164724383; -.
DR VEuPathDB; HostDB:ENSG00000196844; -.
DR eggNOG; ENOG502TEE7; Eukaryota.
DR GeneTree; ENSGT00510000048956; -.
DR HOGENOM; CLU_171487_1_0_1; -.
DR InParanoid; Q6UY27; -.
DR OMA; LKHKQSC; -.
DR OrthoDB; 1510746at2759; -.
DR PhylomeDB; Q6UY27; -.
DR TreeFam; TF339601; -.
DR PathwayCommons; Q6UY27; -.
DR BioGRID-ORCS; 399967; 5 hits in 1059 CRISPR screens.
DR GenomeRNAi; 399967; -.
DR Pharos; Q6UY27; Tdark.
DR PRO; PR:Q6UY27; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6UY27; protein.
DR Bgee; ENSG00000196844; Expressed in corpus epididymis and 43 other tissues.
DR Genevisible; Q6UY27; HS.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR InterPro; IPR029691; PATE2.
DR PANTHER; PTHR47884; PTHR47884; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..113
FT /note="Prostate and testis expressed protein 2"
FT /id="PRO_0000263607"
FT DOMAIN 29..110
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000305"
FT DISULFID 31..57
FT /evidence="ECO:0000255"
FT DISULFID 34..42
FT /evidence="ECO:0000255"
FT DISULFID 49..80
FT /evidence="ECO:0000255"
FT DISULFID 84..101
FT /evidence="ECO:0000255"
FT VAR_SEQ 26..68
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035810"
SQ SEQUENCE 113 AA; 13015 MW; 0D693ABF227D83A2 CRC64;
MLVLFLLGTV FLLCPYWGEL HDPIKATEIM CYECKKYHLG LCYGVMTSCS LKHKQSCAVE
NFYILTRKGQ SMYHYSKLSC MTSCEDINFL GFTKRVELIC CDHSNYCNLP EGV
