PATE2_MOUSE
ID PATE2_MOUSE Reviewed; 111 AA.
AC Q3UW31; Q3UMN1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Prostate and testis expressed protein 2;
DE AltName: Full=PATE-like protein M;
DE Short=PATE-M;
DE Flags: Precursor;
GN Name=Pate2; Synonyms=Gm846;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Epididymis, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=18387948; DOI=10.1074/jbc.m801454200;
RA Levitin F., Weiss M., Hahn Y., Stern O., Papke R.L., Matusik R.,
RA Nandana S.R., Ziv R., Pichinuk E., Salame S., Bera T., Vincent J., Lee B.,
RA Pastan I., Wreschner D.H.;
RT "PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that
RT are expressed in reproductive and neuron-rich tissues and possess
RT neuromodulatory activity.";
RL J. Biol. Chem. 283:16928-16939(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UW31-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UW31-2; Sequence=VSP_021874;
CC -!- TISSUE SPECIFICITY: Expressed in prostate, testis, brain and lung.
CC {ECO:0000269|PubMed:18387948}.
CC -!- SIMILARITY: Belongs to the PATE family. {ECO:0000305}.
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DR EMBL; AK136651; BAE23088.1; -; mRNA.
DR EMBL; AK144787; BAE26067.1; -; mRNA.
DR CCDS; CCDS52756.1; -. [Q3UW31-1]
DR RefSeq; NP_001028593.1; NM_001033421.3. [Q3UW31-1]
DR RefSeq; XP_011240865.1; XM_011242563.2. [Q3UW31-1]
DR AlphaFoldDB; Q3UW31; -.
DR SMR; Q3UW31; -.
DR STRING; 10090.ENSMUSP00000113239; -.
DR PhosphoSitePlus; Q3UW31; -.
DR PaxDb; Q3UW31; -.
DR PRIDE; Q3UW31; -.
DR ProteomicsDB; 287886; -. [Q3UW31-1]
DR ProteomicsDB; 287887; -. [Q3UW31-2]
DR Ensembl; ENSMUST00000118254; ENSMUSP00000113239; ENSMUSG00000074452. [Q3UW31-1]
DR GeneID; 330921; -.
DR KEGG; mmu:330921; -.
DR UCSC; uc009otl.1; mouse. [Q3UW31-1]
DR CTD; 399967; -.
DR MGI; MGI:2685692; Pate2.
DR VEuPathDB; HostDB:ENSMUSG00000074452; -.
DR eggNOG; ENOG502TEE7; Eukaryota.
DR GeneTree; ENSGT00510000048956; -.
DR HOGENOM; CLU_171487_1_0_1; -.
DR InParanoid; Q3UW31; -.
DR OMA; LKHKQSC; -.
DR OrthoDB; 1510746at2759; -.
DR BioGRID-ORCS; 330921; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Pate2; mouse.
DR PRO; PR:Q3UW31; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q3UW31; protein.
DR Bgee; ENSMUSG00000074452; Expressed in primary oocyte and 39 other tissues.
DR ExpressionAtlas; Q3UW31; baseline and differential.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR InterPro; IPR029691; PATE2.
DR PANTHER; PTHR47884; PTHR47884; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..111
FT /note="Prostate and testis expressed protein 2"
FT /id="PRO_0000263608"
FT DOMAIN 27..108
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000305"
FT DISULFID 29..55
FT /evidence="ECO:0000255"
FT DISULFID 32..40
FT /evidence="ECO:0000255"
FT DISULFID 47..78
FT /evidence="ECO:0000255"
FT DISULFID 82..99
FT /evidence="ECO:0000255"
FT VAR_SEQ 98..111
FT /note="CCKHSNYCNLPMGL -> FSWSHSCKTLGRYTEIGFHYQPAGLQRHHLEVTQ
FT RKLLKKQKEPLFNETFDE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021874"
SQ SEQUENCE 111 AA; 13068 MW; B864E49A5F11E753 CRC64;
MFVLVMICLF CQYWGVLNEL EEEDRGLLCY KCKKYHLGLC YGIMTSCVPN HRQTCAAENF
YILTKKGQSM YHYSRLSCMT NCEDINFLSF ERRTELICCK HSNYCNLPMG L
