PATE3_HUMAN
ID PATE3_HUMAN Reviewed; 98 AA.
AC B3GLJ2; B5KFZ3;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Prostate and testis expressed protein 3;
DE AltName: Full=Acrosomal vesicle protein HEL-127;
DE AltName: Full=PATE-like protein DJ;
DE Short=PATE-DJ;
DE Flags: Precursor;
GN Name=PATE3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=18387948; DOI=10.1074/jbc.m801454200;
RA Levitin F., Weiss M., Hahn Y., Stern O., Papke R.L., Matusik R.,
RA Nandana S.R., Ziv R., Pichinuk E., Salame S., Bera T., Vincent J., Lee B.,
RA Pastan I., Wreschner D.H.;
RT "PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that
RT are expressed in reproductive and neuron-rich tissues and possess
RT neuromodulatory activity.";
RL J. Biol. Chem. 283:16928-16939(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=18390568; DOI=10.1093/dnares/dsn005;
RA Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J.,
RA Jin S.H., Zhang Y.L.;
RT "Transcriptome analysis of a cDNA library from adult human epididymis.";
RL DNA Res. 15:115-122(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in prostate and testis.
CC {ECO:0000269|PubMed:18387948}.
CC -!- SIMILARITY: Belongs to the PATE family. {ECO:0000305}.
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DR EMBL; EU703625; ACD81924.1; -; mRNA.
DR EMBL; EF426753; ABR09862.1; -; mRNA.
DR EMBL; AP003087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW67664.1; -; Genomic_DNA.
DR CCDS; CCDS44764.1; -.
DR RefSeq; NP_001123355.3; NM_001129883.3.
DR AlphaFoldDB; B3GLJ2; -.
DR SMR; B3GLJ2; -.
DR STRING; 9606.ENSP00000395505; -.
DR iPTMnet; B3GLJ2; -.
DR PhosphoSitePlus; B3GLJ2; -.
DR BioMuta; PATE3; -.
DR MassIVE; B3GLJ2; -.
DR PaxDb; B3GLJ2; -.
DR PeptideAtlas; B3GLJ2; -.
DR PRIDE; B3GLJ2; -.
DR ProteomicsDB; 3478; -.
DR Antibodypedia; 71916; 62 antibodies from 13 providers.
DR DNASU; 100169851; -.
DR Ensembl; ENST00000445202.2; ENSP00000395505.1; ENSG00000236027.3.
DR GeneID; 100169851; -.
DR KEGG; hsa:100169851; -.
DR MANE-Select; ENST00000445202.2; ENSP00000395505.1; NM_001129883.4; NP_001123355.3.
DR UCSC; uc009zbs.3; human.
DR CTD; 100169851; -.
DR GeneCards; PATE3; -.
DR HGNC; HGNC:35426; PATE3.
DR HPA; ENSG00000236027; Tissue enriched (epididymis).
DR neXtProt; NX_B3GLJ2; -.
DR OpenTargets; ENSG00000236027; -.
DR PharmGKB; PA164724396; -.
DR VEuPathDB; HostDB:ENSG00000236027; -.
DR eggNOG; ENOG502TM14; Eukaryota.
DR GeneTree; ENSGT00690000102487; -.
DR HOGENOM; CLU_178161_0_0_1; -.
DR InParanoid; B3GLJ2; -.
DR OMA; YVHKCCN; -.
DR OrthoDB; 1499349at2759; -.
DR PhylomeDB; B3GLJ2; -.
DR BioGRID-ORCS; 100169851; 8 hits in 1060 CRISPR screens.
DR GenomeRNAi; 100169851; -.
DR Pharos; B3GLJ2; Tdark.
DR PRO; PR:B3GLJ2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; B3GLJ2; protein.
DR Bgee; ENSG00000236027; Expressed in prostate gland and 6 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..98
FT /note="Prostate and testis expressed protein 3"
FT /id="PRO_0000354972"
FT DOMAIN 21..97
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000305"
FT DISULFID 23..50
FT /evidence="ECO:0000255"
FT DISULFID 26..35
FT /evidence="ECO:0000255"
FT DISULFID 42..68
FT /evidence="ECO:0000255"
FT DISULFID 72..88
FT /evidence="ECO:0000255"
FT VARIANT 30
FT /note="T -> K (in dbSNP:rs1025165)"
FT /id="VAR_059884"
FT CONFLICT 58
FT /note="R -> G (in Ref. 2; ABR09862)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 98 AA; 11747 MW; 322630EE4B301F8B CRC64;
MNKHFLFLFL LYCLIVAVTS LQCITCHLRT RTDRCRRGFG VCTAQKGEAC MLLRIYQRNT
LQISYMVCQK FCRDMTFDLR NRTYVHTCCN YNYCNFKL
