ID   PATE4_HUMAN             Reviewed;          98 AA.
AC   P0C8F1;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Prostate and testis expressed protein 4;
DE   AltName: Full=PATE-like protein B;
DE            Short=PATE-B;
DE   Flags: Precursor;
GN   Name=PATE4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   IDENTIFICATION, FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=18387948; DOI=10.1074/jbc.m801454200;
RA   Levitin F., Weiss M., Hahn Y., Stern O., Papke R.L., Matusik R.,
RA   Nandana S.R., Ziv R., Pichinuk E., Salame S., Bera T., Vincent J., Lee B.,
RA   Pastan I., Wreschner D.H.;
RT   "PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that
RT   are expressed in reproductive and neuron-rich tissues and possess
RT   neuromodulatory activity.";
RL   J. Biol. Chem. 283:16928-16939(2008).
CC   -!- FUNCTION: May modulate the function of nicotinic acetylcholine
CC       receptors. May enhance sperm motility. {ECO:0000269|PubMed:18387948}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasmic vesicle,
CC       secretory vesicle, acrosome {ECO:0000269|PubMed:18387948}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in prostate, testis and
CC       spinal cord. Present in the acrosomal region of sperm cells. Present in
CC       apical epithelial cells of prostatic duct.
CC       {ECO:0000269|PubMed:18387948}.
CC   -!- SIMILARITY: Belongs to the PATE family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; AP000842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP003087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS44765.1; -.
DR   RefSeq; NP_001138346.1; NM_001144874.1.
DR   AlphaFoldDB; P0C8F1; -.
DR   STRING; 9606.ENSP00000411439; -.
DR   iPTMnet; P0C8F1; -.
DR   PhosphoSitePlus; P0C8F1; -.
DR   BioMuta; PATE4; -.
DR   DMDM; 317373315; -.
DR   MassIVE; P0C8F1; -.
DR   PaxDb; P0C8F1; -.
DR   PeptideAtlas; P0C8F1; -.
DR   PRIDE; P0C8F1; -.
DR   ProteomicsDB; 52416; -.
DR   Antibodypedia; 50680; 19 antibodies from 10 providers.
DR   DNASU; 399968; -.
DR   Ensembl; ENST00000457514.3; ENSP00000411439.2; ENSG00000237353.7.
DR   GeneID; 399968; -.
DR   KEGG; hsa:399968; -.
DR   MANE-Select; ENST00000457514.3; ENSP00000411439.2; NM_001144874.1; NP_001138346.1.
DR   UCSC; uc001qcv.4; human.
DR   CTD; 399968; -.
DR   GeneCards; PATE4; -.
DR   HGNC; HGNC:35427; PATE4.
DR   HPA; ENSG00000237353; Tissue enriched (seminal).
DR   neXtProt; NX_P0C8F1; -.
DR   OpenTargets; ENSG00000237353; -.
DR   VEuPathDB; HostDB:ENSG00000237353; -.
DR   eggNOG; ENOG502T2SA; Eukaryota.
DR   GeneTree; ENSGT00550000076001; -.
DR   HOGENOM; CLU_181650_0_0_1; -.
DR   InParanoid; P0C8F1; -.
DR   OMA; QGTCIAK; -.
DR   OrthoDB; 1613958at2759; -.
DR   PhylomeDB; P0C8F1; -.
DR   PathwayCommons; P0C8F1; -.
DR   SignaLink; P0C8F1; -.
DR   BioGRID-ORCS; 399968; 4 hits in 1054 CRISPR screens.
DR   GenomeRNAi; 399968; -.
DR   Pharos; P0C8F1; Tdark.
DR   PRO; PR:P0C8F1; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; P0C8F1; protein.
DR   Bgee; ENSG00000237353; Expressed in testis and 39 other tissues.
DR   ExpressionAtlas; P0C8F1; baseline and differential.
DR   GO; GO:0001669; C:acrosomal vesicle; IDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0030548; F:acetylcholine receptor regulator activity; IDA:UniProtKB.
DR   GO; GO:0099601; P:regulation of neurotransmitter receptor activity; IDA:UniProtKB.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..98
FT                   /note="Prostate and testis expressed protein 4"
FT                   /id="PRO_0000354971"
FT   DOMAIN          23..98
FT                   /note="UPAR/Ly6"
FT                   /evidence="ECO:0000305"
FT   DISULFID        25..51
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..36
FT                   /evidence="ECO:0000255"
FT   DISULFID        43..69
FT                   /evidence="ECO:0000255"
FT   DISULFID        73..89
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  11407 MW;  A66EBAB50118DE13 CRC64;
     MRKMNTLLLV SLSFLYLKEV MGLKCNTCIY TEGWKCMAGR GTCIAKENEL CSTTAYFRGD
     KHMYSTHMCK YKCREEESSK RGLLRVTLCC DRNFCNVF