PATE4_MOUSE
ID PATE4_MOUSE Reviewed; 99 AA.
AC Q09098; Q9D248; Q9R018;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Prostate and testis expressed protein 4;
DE AltName: Full=Calcium transport inhibitor;
DE AltName: Full=Caltrin;
DE AltName: Full=PATE-like protein B;
DE Short=PATE-B;
DE AltName: Full=Seminal vesicle protein 7;
DE AltName: Full=Seminal vesicle protein VII;
DE Short=SVS VII;
DE Flags: Precursor;
GN Name=Pate4; Synonyms=Svs7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-41, FUNCTION, AND MASS
RP SPECTROMETRY.
RC STRAIN=CD-1; TISSUE=Seminal vesicle;
RX PubMed=11118436; DOI=10.1074/jbc.m006954200;
RA Luo C.-W., Lin H.-J., Chen Y.-H.;
RT "A novel heat-labile phospholipid-binding protein, SVS VII, in mouse
RT seminal vesicle as a sperm motility enhancer.";
RL J. Biol. Chem. 276:6913-6921(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 24-99.
RC TISSUE=Seminal vesicle;
RX PubMed=1400406; DOI=10.1016/s0021-9258(19)36774-2;
RA Coronel C.E., Winnica D.E., Novella M.L., Lardy H.A.;
RT "Purification, structure, and characterization of caltrin proteins from
RT seminal vesicle of the rat and mouse.";
RL J. Biol. Chem. 267:20909-20915(1992).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=18387948; DOI=10.1074/jbc.m801454200;
RA Levitin F., Weiss M., Hahn Y., Stern O., Papke R.L., Matusik R.,
RA Nandana S.R., Ziv R., Pichinuk E., Salame S., Bera T., Vincent J., Lee B.,
RA Pastan I., Wreschner D.H.;
RT "PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that
RT are expressed in reproductive and neuron-rich tissues and possess
RT neuromodulatory activity.";
RL J. Biol. Chem. 283:16928-16939(2008).
CC -!- FUNCTION: Enhances sperm motility. Binds to calmodulin and inhibits
CC calcium transport into spermatozoa. May modulate the function of
CC nicotinic acetylcholine receptors. {ECO:0000269|PubMed:11118436}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in prostate, testis, eye, kidney and
CC skeletal muscle. Expressed in the dorsal lobe of prostate. Not
CC expressed in the ventral lobe of prostate.
CC {ECO:0000269|PubMed:18387948}.
CC -!- INDUCTION: By castration in the ventral lobe of prostate. This
CC induction is suppressed by subsequent dihydroxytestosterone
CC administration.
CC -!- MASS SPECTROMETRY: Mass=8538.0; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:11118436};
CC -!- SIMILARITY: Belongs to the PATE family. {ECO:0000305}.
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DR EMBL; AF134204; AAD55589.1; -; mRNA.
DR EMBL; AK020540; BAB32129.1; -; mRNA.
DR EMBL; CH466522; EDL25400.1; -; Genomic_DNA.
DR EMBL; BC120764; AAI20765.1; -; mRNA.
DR EMBL; BC120766; AAI20767.1; -; mRNA.
DR CCDS; CCDS22967.1; -.
DR RefSeq; NP_064660.2; NM_020264.4.
DR AlphaFoldDB; Q09098; -.
DR STRING; 10090.ENSMUSP00000034610; -.
DR TCDB; 8.A.31.1.4; the ly-6 neurotoxin-like protein1 precursor (lynx1) family.
DR PhosphoSitePlus; Q09098; -.
DR PaxDb; Q09098; -.
DR PeptideAtlas; Q09098; -.
DR PRIDE; Q09098; -.
DR ProteomicsDB; 287997; -.
DR Antibodypedia; 50680; 19 antibodies from 10 providers.
DR Ensembl; ENSMUST00000034610; ENSMUSP00000034610; ENSMUSG00000032099.
DR GeneID; 56872; -.
DR KEGG; mmu:56872; -.
DR UCSC; uc009otk.2; mouse.
DR CTD; 399968; -.
DR MGI; MGI:1930790; Pate4.
DR VEuPathDB; HostDB:ENSMUSG00000032099; -.
DR eggNOG; ENOG502T2SA; Eukaryota.
DR GeneTree; ENSGT00550000076001; -.
DR HOGENOM; CLU_181650_0_0_1; -.
DR InParanoid; Q09098; -.
DR OMA; QGTCIAK; -.
DR OrthoDB; 1613958at2759; -.
DR PhylomeDB; Q09098; -.
DR BioGRID-ORCS; 56872; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Pate4; mouse.
DR PRO; PR:Q09098; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q09098; protein.
DR Bgee; ENSMUSG00000032099; Expressed in seminal vesicle and 17 other tissues.
DR Genevisible; Q09098; MM.
DR GO; GO:0001669; C:acrosomal vesicle; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0030548; F:acetylcholine receptor regulator activity; ISO:MGI.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IDA:MGI.
DR GO; GO:0099601; P:regulation of neurotransmitter receptor activity; ISO:MGI.
DR GO; GO:0009611; P:response to wounding; IDA:MGI.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR031710; DUF4723.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF15851; DUF4723; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 1: Evidence at protein level;
KW Calcium; Calmodulin-binding; Direct protein sequencing; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:11118436,
FT ECO:0000269|PubMed:1400406"
FT CHAIN 24..99
FT /note="Prostate and testis expressed protein 4"
FT /id="PRO_0000036175"
FT DOMAIN 24..99
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000305"
FT DISULFID 26..52
FT /evidence="ECO:0000255"
FT DISULFID 29..37
FT /evidence="ECO:0000255"
FT DISULFID 44..70
FT /evidence="ECO:0000255"
FT DISULFID 74..90
FT /evidence="ECO:0000255"
FT CONFLICT 40
FT /note="S -> P (in Ref. 1; AAD55589)"
FT /evidence="ECO:0000305"
FT CONFLICT 90..91
FT /note="CC -> FG (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="C -> M (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 98
FT /note="Missing (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 99 AA; 11058 MW; 18D1EC94C3B01D87 CRC64;
MNSVTKISTL LIVILSFLCF VEGLICNSCE KSRDSRCTMS QSRCVAKPGE SCSTVSHFVG
TKHVYSKQMC SPQCKEKQLN TGKKLIYIMC CEKNLCNSF
