PATL2_MOUSE
ID PATL2_MOUSE Reviewed; 529 AA.
AC A2ARM1; A6H5U9; Q9D5L4;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Protein PAT1 homolog 2;
DE AltName: Full=PAT1-like protein 2;
DE AltName: Full=Protein PAT1 homolog a;
DE Short=Pat1a;
GN Name=Patl2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=20826699; DOI=10.1261/rna.2295410;
RA Marnef A., Maldonado M., Bugaut A., Balasubramanian S., Kress M., Weil D.,
RA Standart N.;
RT "Distinct functions of maternal and somatic Pat1 protein paralogs.";
RL RNA 16:2094-2107(2010).
CC -!- FUNCTION: RNA-binding protein that acts as a translational repressor.
CC {ECO:0000250|UniProtKB:Q4V7K4}.
CC -!- SUBUNIT: Interacts with LSM1. {ECO:0000250|UniProtKB:C9JE40}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20826699}. Nucleus
CC {ECO:0000269|PubMed:20826699}.
CC -!- SIMILARITY: Belongs to the PAT1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29742.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK015195; BAB29742.1; ALT_FRAME; mRNA.
DR EMBL; AL845457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC145646; AAI45647.1; -; mRNA.
DR CCDS; CCDS16653.1; -.
DR RefSeq; NP_080527.2; NM_026251.2.
DR RefSeq; XP_017174713.1; XM_017319224.1.
DR AlphaFoldDB; A2ARM1; -.
DR SMR; A2ARM1; -.
DR STRING; 10090.ENSMUSP00000028665; -.
DR PhosphoSitePlus; A2ARM1; -.
DR PaxDb; A2ARM1; -.
DR PRIDE; A2ARM1; -.
DR Antibodypedia; 63580; 77 antibodies from 12 providers.
DR DNASU; 67578; -.
DR Ensembl; ENSMUST00000028665; ENSMUSP00000028665; ENSMUSG00000027233.
DR GeneID; 67578; -.
DR KEGG; mmu:67578; -.
DR UCSC; uc008mae.1; mouse.
DR CTD; 197135; -.
DR MGI; MGI:1914828; Patl2.
DR VEuPathDB; HostDB:ENSMUSG00000027233; -.
DR eggNOG; KOG4592; Eukaryota.
DR GeneTree; ENSGT00520000055649; -.
DR HOGENOM; CLU_009778_0_0_1; -.
DR InParanoid; A2ARM1; -.
DR OMA; CYSEQQS; -.
DR OrthoDB; 950451at2759; -.
DR PhylomeDB; A2ARM1; -.
DR TreeFam; TF323322; -.
DR BioGRID-ORCS; 67578; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Patl2; mouse.
DR PRO; PR:A2ARM1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; A2ARM1; protein.
DR Bgee; ENSMUSG00000027233; Expressed in primary oocyte and 19 other tissues.
DR Genevisible; A2ARM1; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000932; C:P-body; IDA:MGI.
DR GO; GO:0002151; F:G-quadruplex RNA binding; ISO:MGI.
DR GO; GO:0034046; F:poly(G) binding; ISO:MGI.
DR GO; GO:0008266; F:poly(U) RNA binding; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0030371; F:translation repressor activity; ISO:MGI.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IBA:GO_Central.
DR GO; GO:0010607; P:negative regulation of cytoplasmic mRNA processing body assembly; IDA:MGI.
DR GO; GO:0017148; P:negative regulation of translation; ISS:UniProtKB.
DR GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR InterPro; IPR039900; Pat1-like.
DR InterPro; IPR019167; PAT1_dom.
DR PANTHER; PTHR21551; PTHR21551; 1.
DR Pfam; PF09770; PAT1; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..529
FT /note="Protein PAT1 homolog 2"
FT /id="PRO_0000404578"
FT REGION 153..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 19
FT /note="S -> P (in Ref. 3; AAI45647)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="E -> K (in Ref. 3; AAI45647)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="V -> A (in Ref. 3; AAI45647)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="L -> LQ (in Ref. 3; AAI45647)"
FT /evidence="ECO:0000305"
FT CONFLICT 243..247
FT /note="AESLK -> VEFLQ (in Ref. 1; BAB29742)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="P -> L (in Ref. 1; BAB29742)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="K -> E (in Ref. 3; AAI45647)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 529 AA; 59639 MW; 4393AB954493943D CRC64;
MKCLEGLHLQ QRPSKFSVSL APEEGLVCAF QLEEEKENED ECVCSDQAPE VKEEGCGLGD
PAIVSAFQNT QVPQQRGLHS SHRVKVSGAL GMSSASLHFM WQSVFPRASS PAHHFGPQQP
SPDPFLFYSP LTPWPPKLSL PSHLTQLHPQ HQQILQQQQR WRRRRSPTAR SVPAQKPWSR
EPAASDAYAN LMTRKEKDWV IRVQMVQLQS ENPRLDDYYY QKYYQKLEKR QADKELLGQK
TRAESLKLVT PYIQKPEVYE SVVRIEGSLG QVAVSTCFSP RRAIDAVSHG TQEQDTGAAS
SQRLRVLSQI EKMFLQLLKI EEGQNDGLPQ LYHTREQSSQ VEKLFQALKT QEQNNLEEAA
DNLLQVLSVR KGKVLVARLL PFLPPDQAVS LLLYITYHLP LLIQRDMADQ GLHMLFKPLG
KYISHLTFHQ LLHAMQGLML LSPGSSERPV SVVLQNQFGI SLLYALLSHG EQLVSLDPSL
RSSSDCATWT DLVILIAWEI AQLPAASLAE PLAFPRNLLP CSAITWTSN