ID   PATL2_XENTR             Reviewed;         735 AA.
AC   B5DEB9;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Protein PAT1 homolog 2;
DE   AltName: Full=PAT1-like protein 2;
DE   AltName: Full=Protein PAT1 homolog a;
DE            Short=Pat1a;
GN   Name=patl2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that acts as a translational repressor.
CC       {ECO:0000250|UniProtKB:Q4V7K4}.
CC   -!- SUBUNIT: Interacts with ribonucleoprotein complex components. Interacts
CC       with cpeb (By similarity). {ECO:0000250|UniProtKB:Q4V7K4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q4V7K4}. Nucleus
CC       {ECO:0000250|UniProtKB:Q4V7K4}.
CC   -!- SIMILARITY: Belongs to the PAT1 family. {ECO:0000305}.
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DR   EMBL; BC168606; AAI68606.1; -; mRNA.
DR   RefSeq; NP_001135679.1; NM_001142207.1.
DR   RefSeq; XP_012812030.1; XM_012956576.2.
DR   RefSeq; XP_012812031.1; XM_012956577.2.
DR   AlphaFoldDB; B5DEB9; -.
DR   SMR; B5DEB9; -.
DR   STRING; 8364.ENSXETP00000035440; -.
DR   GeneID; 100216240; -.
DR   KEGG; xtr:100216240; -.
DR   CTD; 197135; -.
DR   Xenbase; XB-GENE-5892251; patl2.
DR   InParanoid; B5DEB9; -.
DR   OrthoDB; 950451at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014167; Expressed in ovary and 8 other tissues.
DR   ExpressionAtlas; B5DEB9; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IBA:GO_Central.
DR   GO; GO:0017148; P:negative regulation of translation; ISS:UniProtKB.
DR   GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR   InterPro; IPR039900; Pat1-like.
DR   InterPro; IPR019167; PAT1_dom.
DR   PANTHER; PTHR21551; PTHR21551; 1.
DR   Pfam; PF09770; PAT1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..735
FT                   /note="Protein PAT1 homolog 2"
FT                   /id="PRO_0000404580"
FT   REGION          39..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          336..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..93
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..361
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  83746 MW;  A94C42DC26C773D3 CRC64;
     MDLGSDQLLP EDYFLAEEGA LLEEMAEEDE EIDLYNEVTF GLDQESDEEP TKQEEDHKKP
     VQIPEAPKIE EPEKPQPIKE TKKPEKSPLR EVKIVVESDE EHVDRSIDSG GHTMNSTMDD
     SELGDPAVMR AFHGKPTLES LDSAVVDSGI GSTWSELDTD YDQSGMDSGL WEASPKVSMS
     ATGQILEDKA ILRVMERAPY LPPANLEFLG SPLQRGFMPS QRLQRPEMGV MSPKPYRPRF
     MRQQSPLVPR SMRPPFPFTP PRRGPPIFTP NQSPGFVSQT PFRPMSPNVS TPTRPMTPKM
     VRMHFGPMSP SPSFSPFFSP MGNALQRFKV PGHVTQLHPQ HRRILSQRQR PQSSSRKQWE
     SRPDPYASLM SQKEKEWVIK LQMIQLQSEN PHLDDYYYQA YYEKLERKLA EEELLGERKK
     REPTKLVTPY IQKAEMYESV VHIEGSLGQV AVSTCYSPRR AIDAVSYAMP DEAIKALGYQ
     RLRVLKHTEK VFLLLLEVEE LARKMSHIPE EEHAHFQHKQ NYKVQRIYDI LNMAPCHSED
     ESENEFLQLL QVGKGKKLIA RLLPFLTRVQ AGKILLLVVQ HLPFLIKNDS AEESLSVLYG
     PLKNIINGLS FTELIGVIQE LTRPLPESSD LPLTLAFQNQ FGISLLYCLL SHGERLLSSD
     MPMEPCIGDF EKWTDTVFLV AKELSHVSKS SMVEPLFLPS NLLSLFCRYL DKQTIHKLED
     KMECPAIPPY TAVPS