ID   PATR1_CAEBR             Reviewed;         864 AA.
AC   A8WSQ9;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Protein PAT1 homolog 1;
GN   Name=patr-1; ORFNames=CBG03125;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: RNA-binding protein involved in deadenylation-dependent
CC       decapping of mRNAs, leading to the degradation of mRNAs. Acts as a
CC       scaffold protein that connects deadenylation and decapping machinery
CC       (By similarity). Required for the recruitment of P-body components such
CC       as cgh-1 in somatic blastomeres (By similarity). May play a role in
CC       recruiting the decapping enzyme dcap-1 to cytoplasmic puncta in the
CC       cell body of the posterior touch receptor neuron, PLM (By similarity).
CC       {ECO:0000250, ECO:0000250|UniProtKB:Q20374}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PAT1 family. {ECO:0000305}.
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DR   EMBL; HE601438; CAP23518.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WSQ9; -.
DR   SMR; A8WSQ9; -.
DR   STRING; 6238.CBG03125; -.
DR   WormBase; CBG03125; CBP14509; WBGene00026051; Cbr-patr-1.
DR   eggNOG; KOG4592; Eukaryota.
DR   HOGENOM; CLU_363404_0_0_1; -.
DR   InParanoid; A8WSQ9; -.
DR   OMA; STHNPRH; -.
DR   OrthoDB; 415246at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IBA:GO_Central.
DR   GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR   InterPro; IPR039900; Pat1-like.
DR   PANTHER; PTHR21551; PTHR21551; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; RNA-binding.
FT   CHAIN           1..864
FT                   /note="Protein PAT1 homolog 1"
FT                   /id="PRO_0000404581"
FT   REGION          427..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          518..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          551..602
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..584
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..602
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   864 AA;  97193 MW;  124DF930FFAF06F4 CRC64;
     MDEVKKYGKT LEEIEGELMF GKISFMLFLF HCIFSDDFPE SLADSDEEHN IFDDEFDAAN
     DETFGGGLDN IGENAEQVNC LVRAYHSLFF QTARLRLDDP VWHHPSSSDQ VAPDASAIPF
     PTFGNGDSSD TFKSSFEAES PFLKKSIWGN GADSSFNIWG SDFGIAAVPP SSSFDLDYNS
     IAPNEAQQVS PLVQQKPSSQ IPSMPSSALT VTCLLYHEFL NLISFKLEDF ERMQLGDSTD
     TLTAALNDLQ LGSTNAQSKI EQAPTTLQSA PGEPLKAQTL PKLPVSALSL EELEQKIIRE
     SQTVNVANTQ QTPQGSNRFA HPPPGFTANM KNAQHPAMGP PMGMPGMQMP PPPMGYQQMG
     AIMQELPRLP PLNPQYLPLV PIWLGAIVNN MQLPMGVPPI PPFLYQLLNH YRNPSLVHAM
     IVHSSIPPNS RPNGPQFSGP QVGPHSPGAR GQQRRNSGMP STRTIYDLAL DSFAGYMSFK
     EREWLIRIQF VQCKGSGDPC IDDYYYVRWR ESQIANGWTA HPKPESKQPL PASSESRKDY
     LERIRRMNYR EMQKERLRDR EKERQRERQE RIDRGEERKP RQTLTDKFAT SLGLPSKSST
     HNPRHVLDMK AQVDSVDNQA KKLSDEERKN AVQKKLRTML LRLEGALVLL MEAEELRRTS
     SSDKSQFKDL TSEEKEQEVE KRTSLIIDEF MGDDLPKLMQ MSKGRAVLTR TLKVVGPRDQ
     ARIILSLMIA AGLVSKKMYG EIVLDILPVV HQKVSNLHPD QFKYLVGALN LDNIKRQLMD
     SNMFVRDVML TLYLVSVKNN QNLLEWSKQT KFSSLKMPSS APLGFWRKAL SAVTDAEITE
     FAEDIKYSGV VDCHEVAKLI EQSL