PATR_MYCTU
ID PATR_MYCTU Reviewed; 353 AA.
AC P9WML5; L0TGI3; P72039;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Putative phenylalanine aminotransferase {ECO:0000255|HAMAP-Rule:MF_01513};
DE EC=2.6.1.- {ECO:0000255|HAMAP-Rule:MF_01513};
GN Name=pat {ECO:0000255|HAMAP-Rule:MF_01513}; Synonyms=hisC2;
GN OrderedLocusNames=Rv3772; ORFNames=MTCY13D12.06;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: May catalyze the transamination reaction in phenylalanine
CC biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01513}.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01513};
CC -!- SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000255|HAMAP-Rule:MF_01513}.
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DR EMBL; AL123456; CCP46601.1; -; Genomic_DNA.
DR PIR; H70694; H70694.
DR RefSeq; NP_218289.1; NC_000962.3.
DR RefSeq; WP_003899686.1; NZ_NVQJ01000009.1.
DR PDB; 4R2N; X-ray; 1.98 A; A/B/C/D=2-353.
DR PDB; 4R5Z; X-ray; 1.95 A; A/B/C/D=2-353.
DR PDBsum; 4R2N; -.
DR PDBsum; 4R5Z; -.
DR AlphaFoldDB; P9WML5; -.
DR SMR; P9WML5; -.
DR STRING; 83332.Rv3772; -.
DR PaxDb; P9WML5; -.
DR DNASU; 886105; -.
DR GeneID; 886105; -.
DR KEGG; mtu:Rv3772; -.
DR TubercuList; Rv3772; -.
DR eggNOG; COG0079; Bacteria.
DR OMA; YPDMACT; -.
DR PhylomeDB; P9WML5; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0004400; F:histidinol-phosphate transaminase activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR HAMAP; MF_01023; HisC_aminotrans_2; 1.
DR HAMAP; MF_01513; Phe_aminotrans_2; 1.
DR InterPro; IPR001917; Aminotrans_II_pyridoxalP_BS.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR005861; HisP_aminotrans.
DR InterPro; IPR024892; Pat.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; SSF53383; 1.
DR PROSITE; PS00599; AA_TRANSFER_CLASS_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Aminotransferase; Pyridoxal phosphate; Reference proteome;
KW Transferase.
FT CHAIN 1..353
FT /note="Putative phenylalanine aminotransferase"
FT /id="PRO_0000153517"
FT MOD_RES 217
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01513"
FT HELIX 7..9
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 24..26
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 38..48
FT /evidence="ECO:0007829|PDB:4R5Z"
FT TURN 49..52
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 60..70
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 76..78
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 79..83
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 84..96
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 102..108
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 113..119
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 123..128
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 136..141
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 147..155
FT /evidence="ECO:0007829|PDB:4R5Z"
FT TURN 157..159
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 165..174
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 179..184
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 188..190
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 199..205
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 209..217
FT /evidence="ECO:0007829|PDB:4R5Z"
FT TURN 222..224
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 227..230
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 233..242
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 250..261
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 263..287
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 296..301
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 304..306
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 307..316
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 322..324
FT /evidence="ECO:0007829|PDB:4R5Z"
FT TURN 325..327
FT /evidence="ECO:0007829|PDB:4R5Z"
FT STRAND 328..332
FT /evidence="ECO:0007829|PDB:4R5Z"
FT HELIX 336..352
FT /evidence="ECO:0007829|PDB:4R5Z"
SQ SEQUENCE 353 AA; 38040 MW; E5E49F74DC2436F4 CRC64;
MTARLRPELA GLPVYVPGKT VPGAIKLASN ETVFGPLPSV RAAIDRATDT VNRYPDNGCV
QLKAALARHL GPDFAPEHVA VGCGSVSLCQ QLVQVTASVG DEVVFGWRSF ELYPPQVRVA
GAIPIQVPLT DHTFDLYAML ATVTDRTRLI FVCNPNNPTS TVVGPDALAR FVEAVPAHIL
IAIDEAYVEY IRDGMRPDSL GLVRAHNNVV VLRTFSKAYG LAGLRIGYAI GHPDVITALD
KVYVPFTVSS IGQAAAIASL DAADELLART DTVVAERARV SAELRAAGFT LPPSQANFVW
LPLGSRTQDF VEQAADARIV VRPYGTDGVR VTVAAPEEND AFLRFARRWR SDQ
