ID   PAU23_YEAST             Reviewed;         124 AA.
AC   Q07987; D6VY40;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Seripauperin-23;
DE   AltName: Full=Cell wall protein DAN2;
DE   AltName: Full=Delayed anaerobic protein 2;
DE   Flags: Precursor;
GN   Name=PAU23; Synonyms=DAN2; OrderedLocusNames=YLR037C; ORFNames=L1909;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   INDUCTION.
RX   PubMed=11292809; DOI=10.1128/jb.183.9.2881-2887.2001;
RA   Abramova N.E., Sertil O., Mehta S., Lowry C.V.;
RT   "Reciprocal regulation of anaerobic and aerobic cell wall mannoprotein gene
RT   expression in Saccharomyces cerevisiae.";
RL   J. Bacteriol. 183:2881-2887(2001).
RN   [4]
RP   INDUCTION.
RX   PubMed=11160904; DOI=10.1093/nar/29.3.799;
RA   Cohen B.D., Sertil O., Abramova N.E., Davies K.J.A., Lowry C.V.;
RT   "Induction and repression of DAN1 and the family of anaerobic mannoprotein
RT   genes in Saccharomyces cerevisiae occurs through a complex array of
RT   regulatory sites.";
RL   Nucleic Acids Res. 29:799-808(2001).
RN   [5]
RP   INDUCTION.
RX   PubMed=19762443; DOI=10.1099/mic.0.030726-0;
RA   Luo Z., van Vuuren H.J.;
RT   "Functional analyses of PAU genes in Saccharomyces cerevisiae.";
RL   Microbiology 155:4036-4049(2009).
CC   -!- FUNCTION: Component of the cell wall. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}.
CC   -!- INDUCTION: Induced at low temperature and during anaerobic growth and
CC       completely repressed during aerobic growth. Induced at an early stage
CC       of fermentation and remains almost constant throughout the entire
CC       fermentation process. {ECO:0000269|PubMed:11160904,
CC       ECO:0000269|PubMed:11292809, ECO:0000269|PubMed:19762443}.
CC   -!- PTM: O-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; Z73209; CAA97565.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09356.1; -; Genomic_DNA.
DR   PIR; S64864; S64864.
DR   RefSeq; NP_013138.1; NM_001181924.1.
DR   AlphaFoldDB; Q07987; -.
DR   BioGRID; 31313; 47.
DR   DIP; DIP-4801N; -.
DR   IntAct; Q07987; 1.
DR   STRING; 4932.YLR037C; -.
DR   PaxDb; Q07987; -.
DR   EnsemblFungi; YLR037C_mRNA; YLR037C; YLR037C.
DR   GeneID; 850726; -.
DR   KEGG; sce:YLR037C; -.
DR   SGD; S000004027; PAU23.
DR   VEuPathDB; FungiDB:YLR037C; -.
DR   eggNOG; ENOG502SR1B; Eukaryota.
DR   GeneTree; ENSGT00940000176276; -.
DR   HOGENOM; CLU_136376_0_0_1; -.
DR   BioCyc; YEAST:G3O-32196-MON; -.
DR   PRO; PR:Q07987; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q07987; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0009277; C:fungal-type cell wall; IBA:GO_Central.
DR   GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR   GO; GO:0005199; F:structural constituent of cell wall; IBA:GO_Central.
DR   GO; GO:0031505; P:fungal-type cell wall organization; IBA:GO_Central.
DR   InterPro; IPR000992; SRP1_TIP1.
DR   Pfam; PF00660; SRP1_TIP1; 1.
DR   PROSITE; PS00724; SRP1_TIP1; 1.
PE   2: Evidence at transcript level;
KW   Cell wall; Cell wall biogenesis/degradation; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..124
FT                   /note="Seripauperin-23"
FT                   /id="PRO_0000033241"
SQ   SEQUENCE   124 AA;  13178 MW;  9D6DC46718BBFC36 CRC64;
     MVKLTSIVAG VAAIAAGVAA APATTTLSPS DERVNLVELG VYVSDIRAHL AEYYMFQAAH
     PTETYPVEIA EAVFNYGDFT TMLTGIPADQ VTRVITGVPW YSTRLRPAIS SALSKDGIYT
     AVPN