PAX1H_CAEEL
ID PAX1H_CAEEL Reviewed; 257 AA.
AC Q21272;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Paired box protein 1 homolog {ECO:0000303|PubMed:20714352};
GN Name=pax-1 {ECO:0000312|WormBase:K07C11.1};
GN ORFNames=K07C11.1 {ECO:0000312|WormBase:K07C11.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=20714352; DOI=10.1371/journal.pgen.1001060;
RA Fakhouri T.H., Stevenson J., Chisholm A.D., Mango S.E.;
RT "Dynamic chromatin organization during foregut development mediated by the
RT organ selector gene PHA-4/FoxA.";
RL PLoS Genet. 6:0-0(2010).
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=22675448; DOI=10.1371/journal.pone.0038200;
RA Sahu S.N., Lewis J., Patel I., Bozdag S., Lee J.H., LeClerc J.E.,
RA Cinar H.N.;
RT "Genomic analysis of immune response against Vibrio cholerae hemolysin in
RT Caenorhabditis elegans.";
RL PLoS ONE 7:e38200-e38200(2012).
CC -!- FUNCTION: Transcription factor (By similarity). May play a role in
CC pharyngeal cell differentiation (Probable). May have a protective role
CC in response to infection by the Gram-negative bacterium Vibrio cholerae
CC (PubMed:22675448). {ECO:0000250|UniProtKB:P55771,
CC ECO:0000269|PubMed:22675448, ECO:0000305|PubMed:20714352}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20714352}.
CC -!- DEVELOPMENTAL STAGE: Expressed in 14 pharyngeal cells, which include
CC nine marginal cells, the e2 epithelial cells and the pm8 muscle
CC (PubMed:20714352). Earliest expression in marginal cells is shortly
CC after embryonic cell division ceases, at the late-bean to early-comma
CC stages of development (PubMed:20714352). Expression in these cells
CC diminishes during later embryogenesis and is absent in larvae and
CC adults (PubMed:20714352). {ECO:0000269|PubMed:20714352}.
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DR EMBL; BX284605; CCD64756.1; -; Genomic_DNA.
DR PIR; E89124; E89124.
DR RefSeq; NP_505120.1; NM_072719.1.
DR AlphaFoldDB; Q21272; -.
DR SMR; Q21272; -.
DR IntAct; Q21272; 2.
DR STRING; 6239.K07C11.1; -.
DR PaxDb; Q21272; -.
DR EnsemblMetazoa; K07C11.1.1; K07C11.1.1; WBGene00003937.
DR GeneID; 187105; -.
DR KEGG; cel:CELE_K07C11.1; -.
DR UCSC; K07C11.1; c. elegans.
DR CTD; 187105; -.
DR WormBase; K07C11.1; CE07344; WBGene00003937; pax-1.
DR eggNOG; KOG3517; Eukaryota.
DR GeneTree; ENSGT00940000165812; -.
DR HOGENOM; CLU_1134398_0_0_1; -.
DR InParanoid; Q21272; -.
DR OMA; TAQPWMM; -.
DR OrthoDB; 1339212at2759; -.
DR PhylomeDB; Q21272; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003937; Expressed in pharyngeal muscle cell (C elegans) and 2 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PTHR45636; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Paired box;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..257
FT /note="Paired box protein 1 homolog"
FT /id="PRO_0000455511"
FT DNA_BIND 61..187
FT /note="Paired"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 26..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..120
FT /note="PAI subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 139..187
FT /note="RED subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
SQ SEQUENCE 257 AA; 28529 MW; 7E37D690A527E8F9 CRC64;
MNCDTAQPWM MSSYHPSTTS DVFWTTTPSS TSTTPSSDNG IQQYSSISTS SGYAPANSPA
KTAEVNQLGG VFVNGRPLPF EMRCKIVELS RQGTRPCDIS RQLKISHGCV SKILTRFSEN
GTIMPGTIGG SRPRVTTPKV VEYIRSLKRS DPGIFAWEIR DRLISADICD RANLPSVSSI
SRILRNKNGG NSSSSSSSQL RYIRDQLAEQ QQQQHLQQHQ YMEYNNNELN QISGNLDYQV
SSSNTPPSYD SYHFIAN
