ID   PAX1_CHICK              Reviewed;         203 AA.
AC   P47236;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Paired box protein Pax-1;
DE   Flags: Fragment;
GN   Name=PAX1; Synonyms=GPX-1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=8921581; DOI=10.1046/j.1432-0436.1996.6110013.x;
RA   Barnes G.L., Hsu C.W., Mariani B.D., Tuan R.S.;
RT   "Chicken Pax-1 gene: structure and expression during embryonic somite
RT   development.";
RL   Differentiation 61:13-23(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-110.
RX   PubMed=7647370; DOI=10.1002/aja.1002030102;
RA   Peters H., Doll U., Niessing J.;
RT   "Differential expression of the chicken Pax-1 and Pax-9 gene: in situ
RT   hybridization and immunohistochemical analysis.";
RL   Dev. Dyn. 203:1-16(1995).
CC   -!- FUNCTION: This protein is a transcriptional activator. It may play a
CC       role in the formation of segmented structures of the embryo. May play
CC       an important role in the normal development of the vertebral column (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; U22046; AAA65058.1; -; Genomic_DNA.
DR   EMBL; X82442; CAA57823.1; -; Genomic_DNA.
DR   PIR; I50673; I50673.
DR   AlphaFoldDB; P47236; -.
DR   SMR; P47236; -.
DR   STRING; 9031.ENSGALP00000041207; -.
DR   VEuPathDB; HostDB:geneid_100859138; -.
DR   eggNOG; KOG3517; Eukaryota.
DR   InParanoid; P47236; -.
DR   PhylomeDB; P47236; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0061056; P:sclerotome development; NAS:AgBase.
DR   CDD; cd00131; PAX; 1.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR033206; PAX1.
DR   InterPro; IPR043565; PAX_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45636; PTHR45636; 1.
DR   PANTHER; PTHR45636:SF15; PTHR45636:SF15; 1.
DR   Pfam; PF00292; PAX; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Paired box;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           <1..>203
FT                   /note="Paired box protein Pax-1"
FT                   /id="PRO_0000050174"
FT   DNA_BIND        3..129
FT                   /note="Paired"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          6..62
FT                   /note="PAI subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          81..129
FT                   /note="RED subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          133..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..155
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         203
SQ   SEQUENCE   203 AA;  21880 MW;  9E5F2832110FF405 CRC64;
     EHTYGEVNQL GGVFVNGRPL PNAIRLRIVE LAQLGIRPCD ISRQLRVSHG CVSKILARYN
     ETGSILPGAI GGSKPRVTTP NVVKHIRDYK QGDPGIFAWE IRDRLLADGV CDKYNVPSVS
     SISRILRNKI GSLSQPGGPY DGGKQPPPQP ALPYNPLYQY PYPGPMDPRA AKMGADPPGP
     VPAAHVGLPR SWPSAHSVTN ILG