PAX2H_CAEEL
ID PAX2H_CAEEL Reviewed; 351 AA.
AC Q21263; U4PCL3;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Paired box protein 2 homolog {ECO:0000305};
DE AltName: Full=Paired box transcription factor 2 {ECO:0000312|WormBase:K06B9.5a};
GN Name=pax-2 {ECO:0000312|WormBase:K06B9.5a};
GN ORFNames=K06B9.5 {ECO:0000312|WormBase:K06B9.5a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=17021039; DOI=10.1242/dev.02614;
RA Park D., Jia H., Rajakumar V., Chamberlin H.M.;
RT "Pax2/5/8 proteins promote cell survival in C. elegans.";
RL Development 133:4193-4202(2006).
CC -!- FUNCTION: Transcription factor (PubMed:17021039). Involved in
CC negatively modulating apoptosis in germline and somatic cells, acting
CC in partial redundancy with transcription factor egl-38/PAX5, probably
CC by directly regulating transcription of apoptosis regulator ced-9
CC (PubMed:17021039). May bind to the DNA sequence motif 5'-GTAACG-3' in
CC regulatory elements (PubMed:17021039). {ECO:0000269|PubMed:17021039}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00381,
CC ECO:0000305|PubMed:17021039}. Chromosome {ECO:0000269|PubMed:17021039}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:K06B9.5a};
CC IsoId=Q21263-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:K06B9.5b};
CC IsoId=Q21263-2; Sequence=VSP_061583;
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DR EMBL; BX284604; CCD70278.1; -; Genomic_DNA.
DR EMBL; BX284604; CDH93478.1; -; Genomic_DNA.
DR PIR; T29502; T29502.
DR RefSeq; NP_001294650.1; NM_001307721.1.
DR RefSeq; NP_500513.1; NM_068112.1.
DR SMR; Q21263; -.
DR IntAct; Q21263; 5.
DR STRING; 6239.K06B9.5a; -.
DR PaxDb; Q21263; -.
DR EnsemblMetazoa; K06B9.5a.1; K06B9.5a.1; WBGene00003938.
DR GeneID; 187062; -.
DR KEGG; cel:CELE_K06B9.5; -.
DR UCSC; K06B9.5; c. elegans.
DR CTD; 187062; -.
DR WormBase; K06B9.5a; CE29504; WBGene00003938; pax-2.
DR WormBase; K06B9.5b; CE48918; WBGene00003938; pax-2.
DR eggNOG; KOG3862; Eukaryota.
DR GeneTree; ENSGT00940000165812; -.
DR HOGENOM; CLU_915967_0_0_1; -.
DR InParanoid; Q21263; -.
DR OrthoDB; 592933at2759; -.
DR PhylomeDB; Q21263; -.
DR Reactome; R-CEL-8939245; RUNX1 regulates transcription of genes involved in BCR signaling.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003938; Expressed in larva.
DR ExpressionAtlas; Q21263; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; -; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PTHR45636; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Chromosome; Developmental protein; DNA-binding;
KW Nucleus; Paired box; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..351
FT /note="Paired box protein 2 homolog"
FT /id="PRO_0000456084"
FT DNA_BIND 91..217
FT /note="Paired"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 94..150
FT /note="PAI subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 169..217
FT /note="RED subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT VAR_SEQ 1..83
FT /note="MFTKTFSNNYMTSSQSAYCNLQQYHDSRVCLLKCCRVQKVDPYFPRIALNSA
FT TSYPTVSGTVSLPKAETVEPDLWIKSFKGNE -> METIWRNYSYSTYPSHHNFQL
FT (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061583"
SQ SEQUENCE 351 AA; 38451 MW; 96724FECB59EB835 CRC64;
MFTKTFSNNY MTSSQSAYCN LQQYHDSRVC LLKCCRVQKV DPYFPRIALN SATSYPTVSG
TVSLPKAETV EPDLWIKSFK GNEDPLLSDG SHTGVNQLGG VFVNGRPLPD TIRAQIVEMS
QHGTRPCDIS RQLKVSHGCV SKILGRYYST GSVRPGVIGG SKPKVATPRV VECIAGYKRA
NPTMFAWEIR QKLIEDQICG EENVPSVSSI NRIVRNKSFM AQLATPTSVT PSVARPSSAT
SQNQRSPPRG VQQHMQQSTS VQQLQQFQLT SAATVNSLIS RPAFAIPGTT HSINGLLGTF
PHSSLLDDKF TNLSTHSADM SLVYPTGLVG EHDWAMRTPM VILPQNYCGQ L
