PAX3_XENTR
ID PAX3_XENTR Reviewed; 461 AA.
AC Q28DP6;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Paired box protein Pax-3 {ECO:0000250|UniProtKB:P23760};
DE AltName: Full=Paired-domain transcription factor Pax3 {ECO:0000250|UniProtKB:Q645N4};
GN Name=pax3 {ECO:0000312|EMBL:CAJ82363.1}; ORFNames=TNeu048l09.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ82363.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:CAJ82363.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable transcription factor. Promotes both hatching gland
CC and neural crest cell fates, two of the cell populations that arise
CC from the neural plate border. Acts downstream of msx1 to induce the
CC neural crest, cooperating with zic1 and mediating signals from both the
CC wnt and fgf8 signaling pathways. Induction of hatching gland cell fate
CC is independent of zic1 (By similarity). {ECO:0000250|UniProtKB:Q645N4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P23760,
CC ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-
CC ProRule:PRU00381}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAJ82363.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CR855399; CAJ82363.1; ALT_INIT; mRNA.
DR RefSeq; NP_001006776.2; NM_001006775.2.
DR AlphaFoldDB; Q28DP6; -.
DR SMR; Q28DP6; -.
DR STRING; 8364.ENSXETP00000016629; -.
DR PaxDb; Q28DP6; -.
DR DNASU; 448464; -.
DR GeneID; 448464; -.
DR KEGG; xtr:448464; -.
DR CTD; 5077; -.
DR Xenbase; XB-GENE-482740; pax3.
DR eggNOG; KOG0849; Eukaryota.
DR HOGENOM; CLU_019281_8_0_1; -.
DR InParanoid; Q28DP6; -.
DR OrthoDB; 1126858at2759; -.
DR Reactome; R-XTR-3214847; HATs acetylate histones.
DR Proteomes; UP000008143; Chromosome 5.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0048785; P:hatching gland development; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0014034; P:neural crest cell fate commitment; ISS:UniProtKB.
DR GO; GO:0014029; P:neural crest formation; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.10; -; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR022106; Pax7_C.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PTHR45636; 2.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00292; PAX; 1.
DR Pfam; PF12360; Pax7; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Paired box; Reference proteome; Transcription;
KW Transcription regulation; Wnt signaling pathway.
FT CHAIN 1..461
FT /note="Paired box protein Pax-3"
FT /id="PRO_0000365107"
FT DNA_BIND 34..171
FT /note="Paired"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT DNA_BIND 196..255
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..93
FT /note="PAI subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 113..171
FT /note="RED subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 141..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 50868 MW; 8E8506ADD84C8137 CRC64;
MTSLAGAVPR MMRPGPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV
EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPKQVT TPEVEKKIEE
FKRDNPVSSI SRILRSKFGK GDEEDIELDR KEQEESEKRA KHSIDGILRE RAPASPESEE
GSDIDSEPDL PLKRKQRRSR TTFTAEQLEE LERAFERTHY PDIYTREELA QRAKLTEARV
QVWFSNRRAR WRKQAGANQL MAFNHLIPGA FPPAAMPALP TYQLSETSYQ PTSIPQAVSD
PSNTVHRPQP LPPSSVHQSS LPSNPESSSA YCLPSGRHGF SSYTDSFVPP SGPSNPMNPA
IGNGLSPQVM GLLTNHGGVP HQPQTDYALS PLTGGLEPPT AVSASCSQRL EHMKSLDSLS
TSQSYCPPTY STSGYSMEPV TGYQYPQYGQ SAFHYLKPDI A
