ID   PAX5_XENLA              Reviewed;         388 AA.
AC   Q9YH95;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Paired box protein Pax-5;
DE            Short=XPax-5;
GN   Name=pax5 {ECO:0000250|UniProtKB:Q02548};
GN   Synonyms=pax-5 {ECO:0000312|EMBL:CAA09230.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAA09230.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, AND
RP   TISSUE SPECIFICITY.
RC   TISSUE=Embryonic brain {ECO:0000312|EMBL:CAA09230.1};
RX   PubMed=10322629;
RX   DOI=10.1002/(sici)1520-6408(1999)24:3/4<208::aid-dvg4>3.0.co;2-j;
RA   Heller N., Braendli A.W.;
RT   "Xenopus Pax-2/5/8 orthologues: novel insights into Pax gene evolution and
RT   identification of Pax-8 as the earliest marker for otic and pronephric cell
RT   lineages.";
RL   Dev. Genet. 24:208-219(1999).
CC   -!- FUNCTION: Probable transcription factor.
CC       {ECO:0000250|UniProtKB:Q9PUK5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02548,
CC       ECO:0000255|PROSITE-ProRule:PRU00381}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1 {ECO:0000269|PubMed:10322629};
CC         IsoId=Q9YH95-1; Sequence=Displayed;
CC       Name=2 {ECO:0000269|PubMed:10322629};
CC         IsoId=Q9YH95-2; Sequence=VSP_052393;
CC   -!- TISSUE SPECIFICITY: First detected in mid-neurula embryos in the
CC       folding neural tube. With the completion of neurulation, expression
CC       becomes localized to the midbrain/hindbrain boundary (MHB) till at
CC       least stage 40. Expression is absent from regions adjacent to the MHB.
CC       In tailbuds, weakly and transiently expressed in the developing otic
CC       vesicle from stage 21 to stage 27. {ECO:0000269|PubMed:10322629}.
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DR   EMBL; AJ010503; CAA09230.1; -; mRNA.
DR   RefSeq; NP_001079237.1; NM_001085768.1. [Q9YH95-1]
DR   AlphaFoldDB; Q9YH95; -.
DR   SMR; Q9YH95; -.
DR   GeneID; 378499; -.
DR   KEGG; xla:378499; -.
DR   CTD; 378499; -.
DR   Xenbase; XB-GENE-865318; pax5.L.
DR   OrthoDB; 592933at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 378499; Expressed in spleen.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00131; PAX; 1.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR022130; Pax2_C.
DR   InterPro; IPR043565; PAX_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45636; PTHR45636; 1.
DR   Pfam; PF00292; PAX; 1.
DR   Pfam; PF12403; Pax2_C; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; DNA-binding; Nucleus;
KW   Paired box; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..388
FT                   /note="Paired box protein Pax-5"
FT                   /id="PRO_0000286865"
FT   DNA_BIND        15..141
FT                   /note="Paired"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          18..74
FT                   /note="PAI subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          93..141
FT                   /note="RED subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          143..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         259
FT                   /note="Q -> QVRWLPRLDQVEFSGGSAAQWRDFRLALHHEPHSRTS (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10322629"
FT                   /id="VSP_052393"
SQ   SEQUENCE   388 AA;  42006 MW;  888C66934DFB8D3E CRC64;
     MEIHCKHDPF AAMHRHGGVN QLGGVFVNGR PLPDVVRQRI VELAHQGVRP CDISRQLRVS
     HGCVSKILGR YYETGSIKPG VIGGSKPKVA TPKVVDKIAD YKRQNPTMFA WEIRDRLLAE
     RVCDNDTVPS VSSINRIIRT KVQQPTNQQI PPSNHSIAST GSVTQVSSVS TDSAGSSYSI
     SGILGITSSN AETNKRKRDE GIQESPIPNG HSLPGRDFLR KQMRGDLFTQ QQLDVLDRVF
     ERQHYTDIFT STEPIKPEQT EYSAMASLTG GLDEMKSSLT SPSSADIGGT VPGPQSYPLV
     TGRDLASTTL PGYPPHVPPA GQGSYSAPTL TGMVPGSDFS GSPYSHPQYS SYNDSWRFPN
     PGLLGSPYYY SAARGGAPPA TAAAYDRH