PAX6_BOVIN
ID PAX6_BOVIN Reviewed; 422 AA.
AC Q1LZF1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Paired box protein Pax-6;
DE AltName: Full=Oculorhombin;
GN Name=PAX6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor with important functions in the
CC development of the eye, nose, central nervous system and pancreas.
CC Required for the differentiation of pancreatic islet alpha cells.
CC Competes with PAX4 in binding to a common element in the glucagon,
CC insulin and somatostatin promoters. Regulates specification of the
CC ventral neuron subtypes by establishing the correct progenitor domains
CC (By similarity). Acts as a transcriptional repressor of NFATC1-mediated
CC gene expression (By similarity). {ECO:0000250,
CC ECO:0000250|UniProtKB:P63015}.
CC -!- SUBUNIT: Interacts with MAF and MAFB (By similarity). Interacts with
CC TRIM11; this interaction leads to ubiquitination and proteasomal
CC degradation, as well as inhibition of transactivation, possibly in part
CC by preventing PAX6 binding to consensus DNA sequences (By similarity).
CC Interacts with TLE6/GRG6 (By similarity).
CC {ECO:0000250|UniProtKB:P63015}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P63015}.
CC -!- PTM: Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal
CC degradation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; BC116038; AAI16039.1; -; mRNA.
DR RefSeq; NP_001035735.1; NM_001040645.1.
DR RefSeq; XP_010811018.1; XM_010812716.2.
DR AlphaFoldDB; Q1LZF1; -.
DR SMR; Q1LZF1; -.
DR STRING; 9913.ENSBTAP00000005994; -.
DR PaxDb; Q1LZF1; -.
DR Ensembl; ENSBTAT00000005994; ENSBTAP00000005994; ENSBTAG00000004561.
DR GeneID; 286857; -.
DR KEGG; bta:286857; -.
DR CTD; 5080; -.
DR VEuPathDB; HostDB:ENSBTAG00000004561; -.
DR VGNC; VGNC:32598; PAX6.
DR eggNOG; KOG0849; Eukaryota.
DR GeneTree; ENSGT00940000155391; -.
DR HOGENOM; CLU_019281_1_0_1; -.
DR InParanoid; Q1LZF1; -.
DR OrthoDB; 1152885at2759; -.
DR TreeFam; TF320146; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000004561; Expressed in pigment epithelium of eye and 35 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0050768; P:negative regulation of neurogenesis; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:1904798; P:positive regulation of core promoter binding; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; -; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PTHR45636; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW Paired box; Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..422
FT /note="Paired box protein Pax-6"
FT /id="PRO_0000263070"
FT DNA_BIND 4..130
FT /note="Paired"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT DNA_BIND 210..269
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 7..63
FT /note="PAI subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 82..130
FT /note="RED subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 162..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..422
FT /note="Required for suppression of NFATC1-mediated
FT transcription"
FT /evidence="ECO:0000250|UniProtKB:P63015"
FT COMPBIAS 167..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 46653 MW; B5E7AD2C1B13C383 CRC64;
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN GCVSKILGRY
YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW EIRDRLLSEG VCTNDNIPSV
SSINRVLRNL ASEKQQMGAD GMYDKLRMLN GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ
EGGGENTNSI SSNGEDSDEA QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR
ERLAAKIDLP EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP
QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ TSSYSCMLPT
SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG ATSTGLISPG VSVPVQVPGS EPDMSQYWPR
LQ