PAX6_CHICK
ID PAX6_CHICK Reviewed; 216 AA.
AC P47237;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Paired box protein Pax-6;
DE Flags: Fragment;
GN Name=PAX6;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8125186; DOI=10.1006/dbio.1994.1077;
RA Li H.S., Yang J.M., Jacobson R.D., Pasko D., Sundin O.;
RT "Pax-6 is first expressed in a region of ectoderm anterior to the early
RT neural plate: implications for stepwise determination of the lens.";
RL Dev. Biol. 162:181-194(1994).
RN [2]
RP INTERACTION WITH MAF.
RX PubMed=11036080; DOI=10.1074/jbc.m007643200;
RA Kataoka K., Yoshitomo-Nakagawa K., Shioda S., Nishizawa M.;
RT "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA
RT binding, transactivation, and transforming activities.";
RL J. Biol. Chem. 276:819-826(2001).
CC -!- FUNCTION: May be a transcription factor with important functions in eye
CC and nasal development.
CC -!- SUBUNIT: Interacts with MAF. {ECO:0000269|PubMed:11036080}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; S69508; AAB30163.1; -; mRNA.
DR PIR; I51234; I51234.
DR AlphaFoldDB; P47237; -.
DR BMRB; P47237; -.
DR SMR; P47237; -.
DR STRING; 9031.ENSGALP00000019778; -.
DR PaxDb; P47237; -.
DR VEuPathDB; HostDB:geneid_395943; -.
DR eggNOG; KOG0849; Eukaryota.
DR HOGENOM; CLU_019281_1_0_1; -.
DR InParanoid; P47237; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR043565; PAX_fam.
DR PANTHER; PTHR45636; PTHR45636; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN <1..216
FT /note="Paired box protein Pax-6"
FT /id="PRO_0000050188"
FT DNA_BIND 10..69
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 68..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
SQ SEQUENCE 216 AA; 24469 MW; 08CE98AD1F58333A CRC64;
QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR ERLAAKIDLP EARIQVWFSN
RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP QPTTPGSMLG RTDTALTNTY
SALPPMPSFT MANNLPMQPP VPSQTSSYSC MLPTSPSVNG RSYDTYTPPH MQTHMNSQPM
GTSGTTSTGL ISPGVSVPVQ VPGSEPDMSQ YWPRLQ
