ID   PAX6_ORYLA              Reviewed;         437 AA.
AC   O73917;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Paired box protein Pax-6;
GN   Name=pax6;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Carolina Biological;
RX   PubMed=9651515; DOI=10.1016/s0925-4773(98)00055-0;
RA   Loosli F., Koester R.W., Carl M., Krone A., Wittbrodt J.;
RT   "Six3, a medaka homologue of the Drosophila homeobox gene sine oculis is
RT   expressed in the anterior embryonic shield and the developing eye.";
RL   Mech. Dev. 74:159-164(1998).
CC   -!- FUNCTION: May be a transcription factor with important functions in eye
CC       and nasal development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ000938; CAA04395.1; -; mRNA.
DR   AlphaFoldDB; O73917; -.
DR   BMRB; O73917; -.
DR   SMR; O73917; -.
DR   STRING; 8090.ENSORLP00000012434; -.
DR   Ensembl; ENSORLT00000012436; ENSORLP00000012435; ENSORLG00000009913.
DR   Ensembl; ENSORLT00020008405; ENSORLP00020004175; ENSORLG00020005018.
DR   eggNOG; KOG0849; Eukaryota.
DR   GeneTree; ENSGT00940000155391; -.
DR   InParanoid; O73917; -.
DR   Proteomes; UP000001038; Chromosome 3.
DR   Proteomes; UP000265180; Chromosome 3.
DR   Proteomes; UP000265200; Unplaced.
DR   Bgee; ENSORLG00000009913; Expressed in sexually immature organism and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   CDD; cd00131; PAX; 1.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR043565; PAX_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45636; PTHR45636; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00292; PAX; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Paired box;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..437
FT                   /note="Paired box protein Pax-6"
FT                   /id="PRO_0000050192"
FT   DNA_BIND        23..149
FT                   /note="Paired"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   DNA_BIND        229..288
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          26..82
FT                   /note="PAI subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          101..149
FT                   /note="RED subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          183..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..415
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   437 AA;  48525 MW;  ADA6A49E25B1AC62 CRC64;
     MPQKEYHNQA TWESGVASMM QNSHSGVNQL GGVFVNGRPL PDSTRQKIVE LAHSGARPCD
     ISRILQVSNG CVSKILGRYY ETGSIRPRAI GGSKPRVATP EVVAKIAQYK RECPSIFAWE
     IRDRLLSEGI CTNDNIPSVS SINRVLRNLA SEKQQMGADG MYDKLRMLNG QTGTWGTRPG
     WYPGTSVPGQ PNQDGCQQQD GAGENTNSIS SNGEDSEETQ MRLQLKRKLQ RNRTSFTQEQ
     IEALEKEFER THYPDVFARE RLAAKIDLPE ARIQVWFSNR RAKWRREEKL RNQRRQANNS
     SSHIPISSSF STSVYQAIPQ PTTPVSFTSG SMLGRPDSAL TNTYSALPPM PSFTMANNLP
     MQPSQTSSYS CMLPTSPPVN GRSYETYTPP HMQAHMNSQS MTTSGTTSTG LISPGVSVPV
     QVPGSEPDMS QYWSRLQ