PAX7_MOUSE
ID PAX7_MOUSE Reviewed; 503 AA.
AC P47239; Q9ES16;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2004, sequence version 2.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Paired box protein Pax-7;
GN Name=Pax7; Synonyms=Pax-7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Skeletal muscle;
RX PubMed=11030621; DOI=10.1016/s0092-8674(00)00066-0;
RA Seale P., Sabourin L.A., Girgis-Gabardo A., Mansouri A., Gruss P.,
RA Rudnicki M.A.;
RT "Pax7 is required for the specification of myogenic satellite cells.";
RL Cell 102:777-786(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 36-324, AND DEVELOPMENTAL STAGE.
RX PubMed=1982921; DOI=10.1016/0925-4773(90)90132-6;
RA Jostes B., Walther C., Gruss P.;
RT "The murine paired box gene, Pax7, is expressed specifically during the
RT development of the nervous and muscular system.";
RL Mech. Dev. 33:27-37(1990).
RN [3]
RP FUNCTION, INTERACTION WITH PAXBP1, REGION, AND SUBCELLULAR LOCATION.
RX PubMed=22862948; DOI=10.1016/j.stem.2012.05.022;
RA Diao Y., Guo X., Li Y., Sun K., Lu L., Jiang L., Fu X., Zhu H., Sun H.,
RA Wang H., Wu Z.;
RT "Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the
RT proliferation of muscle precursor cells by an epigenetic mechanism.";
RL Cell Stem Cell 11:231-241(2012).
CC -!- FUNCTION: Transcription factor that is involved in the regulation of
CC muscle stem cells proliferation, playing a role in myogenesis and
CC muscle regeneration. {ECO:0000269|PubMed:22862948}.
CC -!- SUBUNIT: Can bind to DNA as a heterodimer with PAX3. Interacts with
CC DAXX (By similarity). Interacts with PAXBP1; the interaction links PAX7
CC to a WDR5-containing histone methyltransferase complex
CC (PubMed:22862948). {ECO:0000250|UniProtKB:P23759,
CC ECO:0000269|PubMed:22862948}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22862948}.
CC -!- DEVELOPMENTAL STAGE: Expressed specifically during the development of
CC the nervous and muscular system. {ECO:0000269|PubMed:1982921}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF254422; AAG16663.3; -; mRNA.
DR EMBL; U20792; AAA64491.1; -; mRNA.
DR CCDS; CCDS18850.1; -.
DR PIR; I49265; I49265.
DR RefSeq; NP_035169.1; NM_011039.2.
DR AlphaFoldDB; P47239; -.
DR SMR; P47239; -.
DR BioGRID; 202034; 1.
DR CORUM; P47239; -.
DR STRING; 10090.ENSMUSP00000030508; -.
DR iPTMnet; P47239; -.
DR PhosphoSitePlus; P47239; -.
DR MaxQB; P47239; -.
DR PaxDb; P47239; -.
DR PRIDE; P47239; -.
DR Antibodypedia; 14724; 735 antibodies from 41 providers.
DR DNASU; 18509; -.
DR Ensembl; ENSMUST00000030508; ENSMUSP00000030508; ENSMUSG00000028736.
DR GeneID; 18509; -.
DR KEGG; mmu:18509; -.
DR UCSC; uc008vms.1; mouse.
DR CTD; 5081; -.
DR MGI; MGI:97491; Pax7.
DR VEuPathDB; HostDB:ENSMUSG00000028736; -.
DR eggNOG; KOG0849; Eukaryota.
DR GeneTree; ENSGT00940000156759; -.
DR HOGENOM; CLU_019281_8_0_1; -.
DR InParanoid; P47239; -.
DR OMA; CQRADSI; -.
DR PhylomeDB; P47239; -.
DR TreeFam; TF351610; -.
DR BioGRID-ORCS; 18509; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Pax7; mouse.
DR PRO; PR:P47239; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P47239; protein.
DR Bgee; ENSMUSG00000028736; Expressed in superior colliculus and 85 other tissues.
DR ExpressionAtlas; P47239; baseline and differential.
DR Genevisible; P47239; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005667; C:transcription regulator complex; TAS:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; TAS:MGI.
DR GO; GO:0051216; P:cartilage development; IMP:MGI.
DR GO; GO:0006338; P:chromatin remodeling; IMP:MGI.
DR GO; GO:0021904; P:dorsal/ventral neural tube patterning; IDA:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IMP:MGI.
DR GO; GO:0060415; P:muscle tissue morphogenesis; IGI:MGI.
DR GO; GO:0048663; P:neuron fate commitment; IGI:MGI.
DR GO; GO:0031062; P:positive regulation of histone methylation; IDA:MGI.
DR GO; GO:2000288; P:positive regulation of myoblast proliferation; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:MGI.
DR GO; GO:0010453; P:regulation of cell fate commitment; IMP:MGI.
DR GO; GO:0051101; P:regulation of DNA binding; IMP:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:MGI.
DR GO; GO:0014813; P:skeletal muscle satellite cell commitment; IMP:MGI.
DR GO; GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
DR GO; GO:0043403; P:skeletal muscle tissue regeneration; IMP:MGI.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; IGI:MGI.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; -; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR022106; Pax7_C.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PTHR45636; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00292; PAX; 1.
DR Pfam; PF12360; Pax7; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Myogenesis; Nucleus;
KW Paired box; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..503
FT /note="Paired box protein Pax-7"
FT /id="PRO_0000050195"
FT DNA_BIND 34..161
FT /note="Paired"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT DNA_BIND 215..274
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 27..208
FT /note="Sufficient to mediate interaction with PAXBP1"
FT /evidence="ECO:0000269|PubMed:22862948"
FT REGION 37..93
FT /note="PAI subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 113..161
FT /note="RED subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 165..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 477..489
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT CONFLICT 60
FT /note="V -> VV (in Ref. 2; AAA64491)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="L -> W (in Ref. 2; AAA64491)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="D -> G (in Ref. 2; AAA64491)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="V -> F (in Ref. 2; AAA64491)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 503 AA; 54939 MW; 8ECC952C5C2FCA27 CRC64;
MAALPGAVPR MMRPGPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV
EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPRQVA TPDVEKKIEE
YKRENPGMFS WEIRDRLLKD GHCDRSTVPS VSSISRVLRI KFGKKEDDEE GDKKEEDGEK
KAKHSIDGIL GDKGNRLDEG SDVESEPDLP LKRKQRRSRT TFTAEQLEEL EKAFERTHYP
DIYTREELAQ RTKLTEARVQ VWFSNRRARW RKQAGANQLA AFNHLLPGGF PPTGMPTLPP
YQLPDSTYPT TTISQDGGST VHRPQPLPPS TMHQGGLAAA AAAADTSSAY GARHSFSSYS
DSFMNPGAPS NHMNPVSNGL SPQVMSILSN PSAVPPQPQA DFSISPLHGG LDSASSISAS
CSQRADSIKP GDSLPTSQSY CPPTYSTTGY SVDPVAGYQY SQYGQTAVDY LAKNVSLSTQ
RRMKLGEHSA VLGLLPVETG QAY
