PAX8_CANLF
ID PAX8_CANLF Reviewed; 459 AA.
AC P47240; P47241;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Paired box protein Pax-8;
GN Name=PAX8; Synonyms=PAX-8;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8A AND 8G).
RC TISSUE=Thyroid;
RX PubMed=8652674; DOI=10.1016/0167-4781(96)00018-8;
RA van Renterghem P.H.G., Vassart G., Christophe D.;
RT "Pax 8 expression in primary cultured dog thyrocyte is increased by cyclic
RT AMP.";
RL Biochim. Biophys. Acta 1307:97-103(1996).
CC -!- FUNCTION: Thought to encode a transcription factor. It may have a role
CC in kidney cell differentiation. May play a regulatory role in mammalian
CC development.
CC -!- SUBUNIT: Interacts with WWTR1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=8A;
CC IsoId=P47240-1; Sequence=Displayed;
CC Name=8G;
CC IsoId=P47240-2; Sequence=VSP_002371;
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DR EMBL; X83591; CAA58571.1; -; mRNA.
DR EMBL; X83592; CAA58572.1; -; mRNA.
DR PIR; S70361; S52250.
DR PIR; S70362; S52251.
DR RefSeq; NP_001003248.1; NM_001003248.1. [P47240-2]
DR AlphaFoldDB; P47240; -.
DR BMRB; P47240; -.
DR SMR; P47240; -.
DR STRING; 9615.ENSCAFP00000010846; -.
DR PaxDb; P47240; -.
DR Ensembl; ENSCAFT00030010430; ENSCAFP00030009137; ENSCAFG00030005671. [P47240-1]
DR Ensembl; ENSCAFT00040025689; ENSCAFP00040022340; ENSCAFG00040013848. [P47240-1]
DR Ensembl; ENSCAFT00845021871; ENSCAFP00845017204; ENSCAFG00845012268. [P47240-1]
DR GeneID; 403927; -.
DR CTD; 7849; -.
DR VEuPathDB; HostDB:ENSCAFG00845012268; -.
DR eggNOG; KOG3862; Eukaryota.
DR GeneTree; ENSGT00940000161868; -.
DR HOGENOM; CLU_019281_4_0_1; -.
DR InParanoid; P47240; -.
DR OMA; QLRTEAY; -.
DR OrthoDB; 592933at2759; -.
DR TreeFam; TF315397; -.
DR Proteomes; UP000002254; Chromosome 17.
DR Bgee; ENSCAFG00000007309; Expressed in kidney and 30 other tissues.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0071371; P:cellular response to gonadotropin stimulus; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
DR GO; GO:0001823; P:mesonephros development; ISS:UniProtKB.
DR GO; GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
DR GO; GO:0072221; P:metanephric distal convoluted tubule development; ISS:UniProtKB.
DR GO; GO:0072289; P:metanephric nephron tubule formation; ISS:UniProtKB.
DR GO; GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
DR GO; GO:1900215; P:negative regulation of apoptotic process involved in metanephric collecting duct development; ISS:UniProtKB.
DR GO; GO:1900218; P:negative regulation of apoptotic process involved in metanephric nephron tubule development; ISS:UniProtKB.
DR GO; GO:0072305; P:negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis; ISS:UniProtKB.
DR GO; GO:1900212; P:negative regulation of mesenchymal cell apoptotic process involved in metanephros development; ISS:UniProtKB.
DR GO; GO:0071599; P:otic vesicle development; IEA:Ensembl.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0072108; P:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; ISS:UniProtKB.
DR GO; GO:2000594; P:positive regulation of metanephric DCT cell differentiation; ISS:UniProtKB.
DR GO; GO:2000611; P:positive regulation of thyroid hormone generation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0039003; P:pronephric field specification; ISS:UniProtKB.
DR GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
DR GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0072307; P:regulation of metanephric nephron tubule epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:2000612; P:regulation of thyroid-stimulating hormone secretion; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0030878; P:thyroid gland development; ISS:UniProtKB.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0001655; P:urogenital system development; ISS:UniProtKB.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; -; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR022130; Pax2_C.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PTHR45636; 1.
DR Pfam; PF00292; PAX; 1.
DR Pfam; PF12403; Pax2_C; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; Differentiation; DNA-binding;
KW Nucleus; Paired box; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..459
FT /note="Paired box protein Pax-8"
FT /id="PRO_0000050196"
FT DNA_BIND 9..135
FT /note="Paired"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 12..68
FT /note="PAI subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 87..135
FT /note="RED subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 159..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 305
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00288"
FT VAR_SEQ 302..459
FT /note="DPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGGAGVPAGASVPPFNA
FT FPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGN
FT AYGHTPYSSYGEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL -> APPFWICS
FT KSAAPGSQPVPRSRPSMPFPMLPPCTGSSRARPSSQGERWWDPHCPDTHPTSPPVDRAA
FT MPLLPSQAWWQVPHIITVPHQGQVRHPPPPRPLTICSCYGDSGSN (in isoform
FT 8G)"
FT /evidence="ECO:0000303|PubMed:8652674"
FT /id="VSP_002371"
SQ SEQUENCE 459 AA; 48839 MW; 4CC00164A8E56935 CRC64;
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK
ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND
TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY
SINGLLGIAQ PGSDSKRKMD DSDQDSCRLS IDSQSSSSGP RKHLRTDAFS QHHLEPLECP
FERQHYPEAY ASPSHTKGEQ GLYPLPLLNS AALDDGKATL TPSNTPLGRN LSTHQTYPVV
ADPHSPFAIK QETPEVSSSS STPSSLSSSA FLDLQQVGGA GVPAGASVPP FNAFPHAASV
YGQFTGQALL SGREMVGPTL PGYPPHIPTS GQGSYASSAI AGMVAGSEYS GNAYGHTPYS
SYGEAWRFPN SSLLSSPYYY SSTSRPSAPP TTATAFDHL
