ID   PAX8_PONAB              Reviewed;         457 AA.
AC   Q5R9M8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Paired box protein Pax-8;
GN   Name=PAX8;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Thought to encode a transcription factor. It may have a role
CC       in kidney cell differentiation. May play a regulatory role in mammalian
CC       development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with WWTR1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00381}.
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DR   EMBL; CR859358; CAH91532.1; -; mRNA.
DR   RefSeq; NP_001126820.1; NM_001133348.1.
DR   RefSeq; NP_001128942.1; NM_001135470.1.
DR   AlphaFoldDB; Q5R9M8; -.
DR   BMRB; Q5R9M8; -.
DR   SMR; Q5R9M8; -.
DR   STRING; 9601.ENSPPYP00000013583; -.
DR   GeneID; 100189903; -.
DR   KEGG; pon:100189903; -.
DR   CTD; 7849; -.
DR   eggNOG; KOG3862; Eukaryota.
DR   InParanoid; Q5R9M8; -.
DR   OrthoDB; 592933at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:2000611; P:positive regulation of thyroid hormone generation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:2000612; P:regulation of thyroid-stimulating hormone secretion; ISS:UniProtKB.
DR   GO; GO:0030878; P:thyroid gland development; ISS:UniProtKB.
DR   CDD; cd00131; PAX; 1.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR022130; Pax2_C.
DR   InterPro; IPR043565; PAX_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45636; PTHR45636; 1.
DR   Pfam; PF00292; PAX; 1.
DR   Pfam; PF12403; Pax2_C; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus; Paired box;
KW   Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..457
FT                   /note="Paired box protein Pax-8"
FT                   /id="PRO_0000269183"
FT   DNA_BIND        9..136
FT                   /note="Paired"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          12..69
FT                   /note="PAI subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          88..136
FT                   /note="RED subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          160..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         304
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q00288"
SQ   SEQUENCE   457 AA;  48775 MW;  AE2287B61BE8AC45 CRC64;
     MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK
     ILGSRYYETG SIRPGVIGGS KPKVATPKVV EKIGDYKRQN PTMFAWEIRD RLLAEGVCDN
     DTVPSVSSTN RIIRTKVQQP FNLPMDSCVA TKSLSPGHTL IPSSAVTPPE SPQSDSLGST
     YSINGLLGIA QPGSDKRKMD DSDQDSCRLS IDSQSSSSGP RKHLRTDAFS QHHLEPLECP
     FERQHYPEAY ASPSHTKGEQ GLYPLPLLNS TLDDGKATLT PSNTPLGRNL STHQTYPVVA
     DPHSPFAIKQ ETPEVSSSSS TPSSLSSSAF LDLQQVGSGV PAGASVPPFN AFPHAASVYG
     QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG MVAGSEYSGN AYGHTPYSSY
     SEAWRFPNSS LLSSPYYYSS TSRPSAPPTT ATAFDHL