PAX8_RAT
ID PAX8_RAT Reviewed; 457 AA.
AC P51974; Q66HM8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Paired box protein Pax-8;
GN Name=Pax8; Synonyms=Pax-8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thyroid;
RA Zannini M.;
RL Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Thought to encode a transcription factor. It may have a role
CC in kidney cell differentiation. May play a regulatory role in mammalian
CC development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with WWTR1. {ECO:0000250}.
CC -!- INTERACTION:
CC P51974; P23441: Nkx2-1; NbExp=5; IntAct=EBI-1223113, EBI-1223127;
CC P51974; Q8R478: Wbp2; NbExp=4; IntAct=EBI-1223113, EBI-1223229;
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; X94246; CAA63930.1; -; mRNA.
DR EMBL; BC081779; AAH81779.1; -; mRNA.
DR RefSeq; NP_112403.2; NM_031141.2.
DR AlphaFoldDB; P51974; -.
DR BMRB; P51974; -.
DR SMR; P51974; -.
DR IntAct; P51974; 2.
DR STRING; 10116.ENSRNOP00000033966; -.
DR iPTMnet; P51974; -.
DR PhosphoSitePlus; P51974; -.
DR PaxDb; P51974; -.
DR Ensembl; ENSRNOT00000031058; ENSRNOP00000033966; ENSRNOG00000026203.
DR GeneID; 81819; -.
DR KEGG; rno:81819; -.
DR UCSC; RGD:620434; rat.
DR CTD; 7849; -.
DR RGD; 620434; Pax8.
DR eggNOG; KOG3862; Eukaryota.
DR GeneTree; ENSGT00940000161868; -.
DR HOGENOM; CLU_019281_4_0_1; -.
DR InParanoid; P51974; -.
DR OMA; QLRTEAY; -.
DR OrthoDB; 592933at2759; -.
DR PhylomeDB; P51974; -.
DR TreeFam; TF315397; -.
DR PRO; PR:P51974; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000026203; Expressed in kidney and 13 other tissues.
DR ExpressionAtlas; P51974; baseline and differential.
DR Genevisible; P51974; RN.
DR GO; GO:0005654; C:nucleoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0003677; F:DNA binding; IDA:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR GO; GO:0071371; P:cellular response to gonadotropin stimulus; ISO:RGD.
DR GO; GO:0007417; P:central nervous system development; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0001822; P:kidney development; ISO:RGD.
DR GO; GO:0072073; P:kidney epithelium development; ISO:RGD.
DR GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; ISO:RGD.
DR GO; GO:0072164; P:mesonephric tubule development; ISO:RGD.
DR GO; GO:0001823; P:mesonephros development; ISS:UniProtKB.
DR GO; GO:0072278; P:metanephric comma-shaped body morphogenesis; ISO:RGD.
DR GO; GO:0072221; P:metanephric distal convoluted tubule development; ISS:UniProtKB.
DR GO; GO:0072207; P:metanephric epithelium development; ISO:RGD.
DR GO; GO:0072289; P:metanephric nephron tubule formation; ISS:UniProtKB.
DR GO; GO:0072284; P:metanephric S-shaped body morphogenesis; ISO:RGD.
DR GO; GO:0001656; P:metanephros development; ISO:RGD.
DR GO; GO:1900215; P:negative regulation of apoptotic process involved in metanephric collecting duct development; ISS:UniProtKB.
DR GO; GO:1900218; P:negative regulation of apoptotic process involved in metanephric nephron tubule development; ISS:UniProtKB.
DR GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; ISO:RGD.
DR GO; GO:0072305; P:negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis; ISS:UniProtKB.
DR GO; GO:1900212; P:negative regulation of mesenchymal cell apoptotic process involved in metanephros development; ISS:UniProtKB.
DR GO; GO:0071599; P:otic vesicle development; ISO:RGD.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0072108; P:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; ISS:UniProtKB.
DR GO; GO:2000594; P:positive regulation of metanephric DCT cell differentiation; ISS:UniProtKB.
DR GO; GO:2000611; P:positive regulation of thyroid hormone generation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0039003; P:pronephric field specification; ISS:UniProtKB.
DR GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
DR GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0072307; P:regulation of metanephric nephron tubule epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:2000612; P:regulation of thyroid-stimulating hormone secretion; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:RGD.
DR GO; GO:0072050; P:S-shaped body morphogenesis; ISO:RGD.
DR GO; GO:0006790; P:sulfur compound metabolic process; IEP:RGD.
DR GO; GO:0030878; P:thyroid gland development; ISS:UniProtKB.
DR GO; GO:0006351; P:transcription, DNA-templated; ISO:RGD.
DR GO; GO:0001655; P:urogenital system development; ISS:UniProtKB.
DR GO; GO:0003281; P:ventricular septum development; ISO:RGD.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; -; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR022130; Pax2_C.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PTHR45636; 1.
DR Pfam; PF00292; PAX; 1.
DR Pfam; PF12403; Pax2_C; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Nucleus; Paired box;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..457
FT /note="Paired box protein Pax-8"
FT /id="PRO_0000050199"
FT DNA_BIND 9..135
FT /note="Paired"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 12..68
FT /note="PAI subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 87..135
FT /note="RED subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 159..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 304
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00288"
FT CONFLICT 183
FT /note="N -> H (in Ref. 1; CAA63930)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="P -> A (in Ref. 1; CAA63930)"
FT /evidence="ECO:0000305"
FT CONFLICT 195..199
FT /note="NKRKM -> THRGRC (in Ref. 1; CAA63930)"
FT /evidence="ECO:0000305"
FT CONFLICT 205..206
FT /note="DS -> GQ (in Ref. 1; CAA63930)"
FT /evidence="ECO:0000305"
FT CONFLICT 377
FT /note="T -> S (in Ref. 1; CAA63930)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 457 AA; 48806 MW; 50946E0829936D62 CRC64;
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK
ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND
TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY
SINGLLGIAQ PGSDNKRKMD DSDQDSCRLS IDSQSSSSGP RKHLRTDTFG QHHLEPLECP
FERQHYPEAY ASPSHTKGEQ GLYPLPLLNS TLDDGKATLT PSNTPLGRNL STHQTYPVVA
DPHSPYAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN AFSHAASVYG
QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG MVAGSEYSGN AYSHTPYASY
SEAWRFPNSS LLSSPYYYSS TTRPSAPPTS ATAFDHL
