ID   PAX8_XENTR              Reviewed;         458 AA.
AC   A0JMA6;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Paired box protein Pax-8;
DE   Flags: Fragment;
GN   Name=pax8 {ECO:0000250|UniProtKB:Q06710};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAI25806.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6 {ECO:0000312|EMBL:AAI25806.1};
RC   TISSUE=Oviduct {ECO:0000312|EMBL:AAI25806.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcription factor. Involved in kidney
CC       development, acting synergistically with lhx1/lim-1 to establish the
CC       pronephric primordium in late gastrulae/early neurulae (By similarity).
CC       {ECO:0000250|UniProtKB:Q9PUK5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q06710,
CC       ECO:0000255|PROSITE-ProRule:PRU00381}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI25806.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC125805; AAI25806.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001072769.2; NM_001079301.2.
DR   AlphaFoldDB; A0JMA6; -.
DR   SMR; A0JMA6; -.
DR   STRING; 8364.ENSXETP00000052275; -.
DR   PaxDb; A0JMA6; -.
DR   DNASU; 780226; -.
DR   GeneID; 780226; -.
DR   KEGG; xtr:780226; -.
DR   CTD; 7849; -.
DR   Xenbase; XB-GENE-483693; pax8.
DR   eggNOG; KOG3862; Eukaryota.
DR   HOGENOM; CLU_019281_4_0_1; -.
DR   InParanoid; A0JMA6; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:1900218; P:negative regulation of apoptotic process involved in metanephric nephron tubule development; ISS:UniProtKB.
DR   GO; GO:1900212; P:negative regulation of mesenchymal cell apoptotic process involved in metanephros development; ISS:UniProtKB.
DR   GO; GO:2000611; P:positive regulation of thyroid hormone generation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0039003; P:pronephric field specification; ISS:UniProtKB.
DR   GO; GO:0039020; P:pronephric nephron tubule development; ISS:UniProtKB.
DR   GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
DR   GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR   GO; GO:0001655; P:urogenital system development; ISS:UniProtKB.
DR   CDD; cd00131; PAX; 1.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR022130; Pax2_C.
DR   InterPro; IPR043565; PAX_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45636; PTHR45636; 1.
DR   Pfam; PF00292; PAX; 1.
DR   Pfam; PF12403; Pax2_C; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Paired box;
KW   Reference proteome; Segmentation polarity protein; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..458
FT                   /note="Paired box protein Pax-8"
FT                   /id="PRO_0000284704"
FT   DNA_BIND        18..144
FT                   /note="Paired"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          21..77
FT                   /note="PAI subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          96..144
FT                   /note="RED subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          198..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   458 AA;  48647 MW;  CB67EDB4046F38E0 CRC64;
     ELITERGCSG PASNLNIGHG GLNQLGGAFV NGRPLPEVVR QRIVDLAHQG VRPCDISRQL
     RVSHGCVSKI LGRYYETGSI RPGVIGGSKP KVATPKVVEK IGDYKRQNPT MFAWEIRDRL
     LAEGVCDNDT VPSVSSINRI IRTKVQQLFN LPMESCVKSL SPGQTLIPSS AVTPPESPHS
     DSLGSTYSIS GLLGITQPGA DGKRKLDDSD QESCRLSIDS QGSMGISRKQ LRTEAYGHHP
     LDALECHFQR QHFPESYSSS THSKTEQALY TLPLLNNAMD DGKSSLTSTN TTIGRNLSTH
     QGYSALSELS AFTIKQEASD SSSASSTPSS LCSPTFLDLQ PISSGCSAPS FSAFSHPASV
     YGQFTSHMAS GRDVVGSTLP GYPPHIPSGQ GNYASSAIAG MVAAGGDYSG NAYSHGAYAA
     YGESWRFPSS SLLGSPYYYS SATRTAPPPT TAGAYDLL