ID   PAX9_MACMU              Reviewed;         341 AA.
AC   Q2VL61;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Paired box protein Pax-9;
GN   Name=PAX9;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate 19935-305;
RX   PubMed=16326750; DOI=10.1093/molbev/msj072;
RA   Perry G.H., Verrelli B.C., Stone A.C.;
RT   "Molecular evolution of the primate developmental genes MSX1 and PAX9.";
RL   Mol. Biol. Evol. 23:644-654(2006).
CC   -!- FUNCTION: Transcription factor required for normal development of
CC       thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal
CC       elements of skull and larynx as well as distal limbs. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with KDM5B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; DQ067510; AAZ39855.1; -; Genomic_DNA.
DR   EMBL; DQ067508; AAZ39855.1; JOINED; Genomic_DNA.
DR   EMBL; DQ067509; AAZ39855.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q2VL61; -.
DR   SMR; Q2VL61; -.
DR   STRING; 9544.ENSMMUP00000012620; -.
DR   eggNOG; KOG3517; Eukaryota.
DR   HOGENOM; CLU_019281_3_0_1; -.
DR   InParanoid; Q2VL61; -.
DR   OMA; ASTMAPY; -.
DR   TreeFam; TF315397; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00131; PAX; 1.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR033204; PAX9.
DR   InterPro; IPR043565; PAX_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45636; PTHR45636; 1.
DR   PANTHER; PTHR45636:SF13; PTHR45636:SF13; 1.
DR   Pfam; PF00292; PAX; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Nucleus; Paired box;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..341
FT                   /note="Paired box protein Pax-9"
FT                   /id="PRO_0000050207"
FT   DNA_BIND        4..130
FT                   /note="Paired"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          7..63
FT                   /note="PAI subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          82..130
FT                   /note="RED subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          168..189
FT                   /note="Interaction with KDM5B"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   341 AA;  36408 MW;  AD549C8F48C81B1A CRC64;
     MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH GCVSKILARY
     NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW EIRDRLLADG VCDKYNVPSV
     SSISRILRNK IGNLAQQGHY DSYKQHQPTP QPALPYNHIY SYPSPITAAA AKVPTPPGVP
     AIPGSVAMPR TWPSSHSVTD ILGIRSITDQ VSDSSPYHSP KVEEWSSLGR NNFPATAPHA
     VNGLEKGVLE QEAKYGQAPN GLPAVGSFVS ASSMAPYPTP AQVSPYMTYS AAPSGYVAGH
     GWQHAGSTPL SPHNCDIPAS LAFKGMQAAR EGSHSVTASA L