ID   PAX9_MOUSE              Reviewed;         342 AA.
AC   P47242;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 162.
DE   RecName: Full=Paired box protein Pax-9;
GN   Name=Pax9; Synonyms=Pax-9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7649395; DOI=10.1006/dbio.1995.1248;
RA   Neubuesser A., Koseki H., Balling R.;
RT   "Characterization and developmental expression of Pax9, a paired-box-
RT   containing gene related to Pax1.";
RL   Dev. Biol. 170:701-716(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-111.
RC   STRAIN=C57BR/Y;
RX   PubMed=8358169; DOI=10.1007/bf00360584;
RA   Wallin J., Mizutani Y., Imai K., Miyashita N., Moriwaki K., Taniguchi M.,
RA   Koseki H., Balling R.;
RT   "A new Pax gene, Pax-9, maps to mouse chromosome 12.";
RL   Mamm. Genome 4:354-358(1993).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=9732271; DOI=10.1101/gad.12.17.2735;
RA   Peters H., Neubuser A., Kratochwil K., Balling R.;
RT   "Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and
RT   exhibit craniofacial and limb abnormalities.";
RL   Genes Dev. 12:2735-2747(1998).
CC   -!- FUNCTION: Transcription factor required for normal development of
CC       thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal
CC       elements of skull and larynx as well as distal limbs.
CC       {ECO:0000269|PubMed:9732271}.
CC   -!- SUBUNIT: Interacts with KDM5B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: In the embryo, expressed in pharyngeal pouches and
CC       derivatives, developing vertebral column, tail, head and limbs.
CC   -!- DEVELOPMENTAL STAGE: In the embryo, expression increases slightly from
CC       day 9.5 to day 11.5, remains almost constant until day 14.5 and then
CC       decreases.
CC   -!- DISRUPTION PHENOTYPE: Death shortly after birth. Mice lack thymus,
CC       parathyroid glands, ultimobranchial bodies and teeth. They show
CC       craniofacial and visceral malformations as well as malformations of
CC       their distal limbs. {ECO:0000269|PubMed:9732271}.
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DR   EMBL; X84000; CAA58824.1; -; mRNA.
DR   EMBL; BC005794; AAH05794.1; -; mRNA.
DR   EMBL; X73037; CAA51518.1; -; Genomic_DNA.
DR   CCDS; CCDS25924.1; -.
DR   PIR; I48740; S57652.
DR   RefSeq; NP_035171.1; NM_011041.3.
DR   RefSeq; XP_006515642.1; XM_006515579.3.
DR   RefSeq; XP_006515643.1; XM_006515580.3.
DR   RefSeq; XP_006515644.1; XM_006515581.3.
DR   RefSeq; XP_017170480.1; XM_017314991.1.
DR   AlphaFoldDB; P47242; -.
DR   SMR; P47242; -.
DR   BioGRID; 202036; 2.
DR   IntAct; P47242; 4.
DR   STRING; 10090.ENSMUSP00000117928; -.
DR   iPTMnet; P47242; -.
DR   PhosphoSitePlus; P47242; -.
DR   PaxDb; P47242; -.
DR   PRIDE; P47242; -.
DR   ProteomicsDB; 287785; -.
DR   TopDownProteomics; P47242; -.
DR   Antibodypedia; 9893; 315 antibodies from 36 providers.
DR   DNASU; 18511; -.
DR   Ensembl; ENSMUST00000001538; ENSMUSP00000001538; ENSMUSG00000001497.
DR   Ensembl; ENSMUST00000153250; ENSMUSP00000117928; ENSMUSG00000001497.
DR   GeneID; 18511; -.
DR   KEGG; mmu:18511; -.
DR   UCSC; uc007npi.1; mouse.
DR   CTD; 5083; -.
DR   MGI; MGI:97493; Pax9.
DR   VEuPathDB; HostDB:ENSMUSG00000001497; -.
DR   eggNOG; KOG3517; Eukaryota.
DR   GeneTree; ENSGT00940000159896; -.
DR   HOGENOM; CLU_019281_3_0_1; -.
DR   InParanoid; P47242; -.
DR   OMA; ASTMAPY; -.
DR   OrthoDB; 1339212at2759; -.
DR   PhylomeDB; P47242; -.
DR   TreeFam; TF315397; -.
DR   BioGRID-ORCS; 18511; 2 hits in 74 CRISPR screens.
DR   PRO; PR:P47242; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; P47242; protein.
DR   Bgee; ENSMUSG00000001497; Expressed in parotid gland and 131 other tissues.
DR   ExpressionAtlas; P47242; baseline and differential.
DR   Genevisible; P47242; MM.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005667; C:transcription regulator complex; TAS:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IMP:NTNU_SB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; TAS:MGI.
DR   GO; GO:0071363; P:cellular response to growth factor stimulus; IDA:MGI.
DR   GO; GO:0007492; P:endoderm development; IMP:MGI.
DR   GO; GO:0060325; P:face morphogenesis; IGI:MGI.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR   GO; GO:0042476; P:odontogenesis; IGI:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0042481; P:regulation of odontogenesis; IGI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:MGI.
DR   CDD; cd00131; PAX; 1.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR033204; PAX9.
DR   InterPro; IPR043565; PAX_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45636; PTHR45636; 1.
DR   PANTHER; PTHR45636:SF13; PTHR45636:SF13; 1.
DR   Pfam; PF00292; PAX; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Paired box;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Paired box protein Pax-9"
FT                   /id="PRO_0000050208"
FT   DNA_BIND        4..130
FT                   /note="Paired"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          7..63
FT                   /note="PAI subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          82..130
FT                   /note="RED subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          168..189
FT                   /note="Interaction with KDM5B"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   342 AA;  36389 MW;  A4FB714FE541A96C CRC64;
     MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH GCVSKILARY
     NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW EIRDRLLADG VCDKYNVPSV
     SSISRILRNK IGNLAQQGHY DSYKQHQPAP QPALPYNHIY SYPSPITAAA AKVPTPPGVP
     AIPGSVALPR TWPSSHSVTD ILGIRSITDQ GVSDSSPYHS PKVEEWSSLG RNNFPAAAPH
     AVNGLEKGAL EQEAKYGQAP NGLPAVSSFV SASSMAPYPT PAQVSPYMTY SAAPSGYVAG
     HGWQHAGSTP LSPHNCDIPA SLAFKGMQAA REGSHSVTAS AL