ID   PAX9_PROCO              Reviewed;         341 AA.
AC   Q2VL50;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Paired box protein Pax-9;
GN   Name=PAX9;
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate 6667;
RX   PubMed=16326750; DOI=10.1093/molbev/msj072;
RA   Perry G.H., Verrelli B.C., Stone A.C.;
RT   "Molecular evolution of the primate developmental genes MSX1 and PAX9.";
RL   Mol. Biol. Evol. 23:644-654(2006).
CC   -!- FUNCTION: Transcription factor required for normal development of
CC       thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal
CC       elements of skull and larynx as well as distal limbs. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with KDM5B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; DQ067543; AAZ39866.1; -; Genomic_DNA.
DR   EMBL; DQ067541; AAZ39866.1; JOINED; Genomic_DNA.
DR   EMBL; DQ067542; AAZ39866.1; JOINED; Genomic_DNA.
DR   RefSeq; XP_012513511.1; XM_012658057.1.
DR   AlphaFoldDB; Q2VL50; -.
DR   SMR; Q2VL50; -.
DR   STRING; 379532.ENSPCOP00000020021; -.
DR   Ensembl; ENSPCOT00000030670; ENSPCOP00000020019; ENSPCOG00000021966.
DR   GeneID; 105821363; -.
DR   CTD; 5083; -.
DR   GeneTree; ENSGT00940000159896; -.
DR   OMA; ASTMAPY; -.
DR   OrthoDB; 1339212at2759; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009887; P:animal organ morphogenesis; IEA:InterPro.
DR   CDD; cd00131; PAX; 1.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR033204; PAX9.
DR   InterPro; IPR043565; PAX_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45636; PTHR45636; 1.
DR   PANTHER; PTHR45636:SF13; PTHR45636:SF13; 1.
DR   Pfam; PF00292; PAX; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Nucleus; Paired box;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..341
FT                   /note="Paired box protein Pax-9"
FT                   /id="PRO_0000050211"
FT   DNA_BIND        4..130
FT                   /note="Paired"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          7..63
FT                   /note="PAI subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          82..130
FT                   /note="RED subdomain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT   REGION          168..189
FT                   /note="Interaction with KDM5B"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   341 AA;  36347 MW;  49BD3A0D31371D45 CRC64;
     MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH GCVSKILARY
     NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW EIRDRLLADG VCDKYNVPSV
     SSISRILRNK IGNLAQQGHY DSYKQHQPAP QPALPYNHIY SYPSPITAAA AKVPTPPGVP
     AIPGSVAMPR TWPSSHSVTD ILGIRSITDQ VNDSSPYHSP KVEEWSSLGR NNFPAAAPHA
     VNGLEKGALE QEAKYGQAPN GLPAVSSFVS ASSMAPYPTP AQVSPYMTYS AAPSGYVAGH
     GWQHAGGTPL SPHNCDIPAS LAFKGMQAAR EGSHSVTASA L