ID   PAXI1_DANRE             Reviewed;         943 AA.
AC   Q5XIY8;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=PAX-interacting protein 1;
DE   AltName: Full=PAX transactivation activation domain-interacting protein;
GN   Name=paxip1; ORFNames=zgc:92593;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in DNA damage response. May function as
CC       transcriptional cofactor in TGF beta signaling. Accentuates Smad2-
CC       dependent transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with smad2 via its last three BRCT domain-containing
CC       regions in an activin signal-dependent manner. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC083530; AAH83530.1; -; mRNA.
DR   AlphaFoldDB; Q5XIY8; -.
DR   SMR; Q5XIY8; -.
DR   STRING; 7955.ENSDARP00000113779; -.
DR   PaxDb; Q5XIY8; -.
DR   PeptideAtlas; Q5XIY8; -.
DR   ZFIN; ZDB-GENE-041010-214; paxip1.
DR   eggNOG; KOG2043; Eukaryota.
DR   InParanoid; Q5XIY8; -.
DR   Reactome; R-DRE-5693571; Nonhomologous End-Joining (NHEJ).
DR   PRO; PR:Q5XIY8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0044666; C:MLL3/4 complex; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 3.40.50.10190; -; 4.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR037886; Paxip1.
DR   PANTHER; PTHR23196:SF31; PTHR23196:SF31; 2.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF12738; PTCB-BRCT; 2.
DR   SMART; SM00292; BRCT; 4.
DR   SUPFAM; SSF52113; SSF52113; 4.
DR   PROSITE; PS50172; BRCT; 4.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..943
FT                   /note="PAX-interacting protein 1"
FT                   /id="PRO_0000296264"
FT   DOMAIN          8..93
FT                   /note="BRCT 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT   DOMAIN          94..182
FT                   /note="BRCT 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT   DOMAIN          664..756
FT                   /note="BRCT 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT   DOMAIN          763..851
FT                   /note="BRCT 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT   REGION          190..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           730..747
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        190..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..264
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..430
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..507
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   943 AA;  108033 MW;  0EB659817675CD56 CRC64;
     MSEDDLKVPE ELFKDVKFYV VGDIDQKVVQ LLKSGKGKEV SYNALATHII AEDGDNPEVG
     ESREVFDLPV VKPSWVILSV KCGDLLPVTG FSPESGQVFF GVTACLPHLA EDLNALWAFI
     TFYGGDCQLH FNKKCTHLVV PEPKGAKYEC ALRHNNIKIV TPEWILDSVK EKNRKDEMLY
     HPRLTLYDAP EEEGSEYENE RSSRSEGSYS DRRSPHSRRS SPTSSRDASP AGRRSPSTKH
     ERKSELMFDD SDDSSPEKED RNLNWTPAEV LPPGPAKRRL QPGKETGLIN LCANVPPVPG
     SFGPPDARMV GAGAGAGGGV PMGVERLEVM SEWNSAARTL RNITNNTDTQ QPSRPSNVAH
     IIQSFSASSK GVVDHMGNQG QSGIPNQLLL KAQQQLPPEA QQQLLQQQQQ QSHQLQQQQQ
     QHQMAQQHPM MLPQVMQMHH HQQQQQHQPP PQQQQQQQNQ QGFPQMPPQS HQFLQQQMHQ
     QMYSQHQQQQ QQQQQQQQQH AFPQQMRPQQ LPRLPLQHQQ QHVLQQQLQL QQQHRLQLQL
     QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQKQQQQQQQ NQQQMHQQYL QQQQHFLQQQ
     LQQQHMQQLQ QQQQMQQQQQ QHLQNQQPLQ HQNQQVNPHQ TQTMLQPPIT SAQLFGHEPG
     HDIPEEGFLV GCIFAIADYP EQMADKQLLA TWKRIIQLNG GTVDSALNRC THLLCESQVS
     NTYLQALREG KRCVTAHWLN TVLKKKKMVP PHRTLHLPFS FPPGAKPCAQ HIISVTGFVD
     SDRDDLKLMA YLAGARYTGY LCRSNTVLIC KEPSGLKYEK AKEWRIPCVN AQWLCDILLG
     NFEALRQIQH SKYTQFNLPD PLAPNHHLVH NLLSAWRIPV KISPEALASL RLQLKQKQAD
     VSVQPPSKRP KLEELPTPTK SFHLIQHLTS FSQALNLCRL SST