ID   PAX_I02A5               Reviewed;         252 AA.
AC   P0CK73;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   02-DEC-2020, entry version 20.
DE   RecName: Full=Protein PA-X;
GN   Name=PA;
OS   Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=279803;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9691; Panthera pardus (Leopard) (Felis pardus).
OH   NCBI_TaxID=9694; Panthera tigris (Tiger).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15148370; DOI=10.1073/pnas.0402443101;
RA   Guan Y., Poon L.L.M., Cheung C.Y., Ellis T.M., Lim W., Lipatov A.S.,
RA   Chan K.H., Sturm-Ramirez K.M., Cheung C.L., Leung Y.H.C., Yuen K.Y.,
RA   Webster R.G., Peiris J.S.M.;
RT   "H5N1 influenza: a protean pandemic threat.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:8156-8161(2004).
RN   [2]
RP   SEQUENCE REVISION.
RA   Guan Y., Poon L.L.M., Cheung C.Y., Ellis T.M., Lim W., Lipatov A.S.,
RA   Chan K.H., Sturm-Ramirez K.M., Cheung C.L., Leung Y.H.C., Yuen K.Y.,
RA   Webster R.G., Peiris J.S.M.;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the modulation of host immune response.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=PA-X;
CC         IsoId=P0CK73-1; Sequence=Displayed;
CC       Name=PA;
CC         IsoId=Q6J835-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the influenza viruses PA-X family.
CC       {ECO:0000305}.
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DR   EMBL; AY576413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0CK73; -.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.91.90; -; 1.
DR   InterPro; IPR001009; PA/PA-X.
DR   InterPro; IPR038372; PA/PA-X_sf.
DR   Pfam; PF00603; Flu_PA; 1.
PE   3: Inferred from homology;
KW   Ribosomal frameshifting.
FT   CHAIN           1..252
FT                   /note="Protein PA-X"
FT                   /id="PRO_0000419356"
SQ   SEQUENCE   252 AA;  29478 MW;  8A7E92B7DC3C6985 CRC64;
     MEDFVRQCFN PMIVELTEKA MKEYGEDPKI ETNKFAAICT HLEVCFMYSD FHFIDERSES
     IIVESGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGV EKPKFIPDLY DYKENRFIEI
     GVTRREVHTY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
     EMASRGLWDS FVNPREAKRQ LKKNLKSLEP CADLPTKVSH RTSPALKTLE PMWMDSNRTA
     ALRASFLKCQ KK