ID   PAX_I18A0               Reviewed;         252 AA.
AC   P0CK68;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   02-DEC-2020, entry version 23.
DE   RecName: Full=Protein PA-X;
GN   Name=PA;
OS   Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus
OS   (strain A/South Carolina/1/1918 H1N1)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=88776;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16208372; DOI=10.1038/nature04230;
RA   Taubenberger J.K., Reid A.H., Lourens R.M., Wang R., Jin G., Fanning T.G.;
RT   "Characterization of the 1918 influenza virus polymerase genes.";
RL   Nature 437:889-893(2005).
RN   [2]
RP   CHARACTERIZATION, AND FUNCTION.
RX   PubMed=22745253; DOI=10.1126/science.1222213;
RA   Jagger B.W., Wise H.M., Kash J.C., Walters K.A., Wills N.M., Xiao Y.L.,
RA   Dunfee R.L., Schwartzman L.M., Ozinsky A., Bell G.L., Dalton R.M., Lo A.,
RA   Efstathiou S., Atkins J.F., Firth A.E., Taubenberger J.K., Digard P.;
RT   "An overlapping protein-coding region in influenza A virus segment 3
RT   modulates the host response.";
RL   Science 337:199-204(2012).
CC   -!- FUNCTION: May play a role in the modulation of host immune response.
CC       {ECO:0000269|PubMed:22745253}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=PA-X;
CC         IsoId=P0CK68-1; Sequence=Displayed;
CC       Name=PA;
CC         IsoId=Q3HM39-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the influenza viruses PA-X family.
CC       {ECO:0000305}.
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DR   EMBL; DQ208311; -; NOT_ANNOTATED_CDS; mRNA.
DR   SMR; P0CK68; -.
DR   Proteomes; UP000008430; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.91.90; -; 1.
DR   InterPro; IPR001009; PA/PA-X.
DR   InterPro; IPR038372; PA/PA-X_sf.
DR   Pfam; PF00603; Flu_PA; 1.
PE   1: Evidence at protein level;
KW   Ribosomal frameshifting.
FT   CHAIN           1..252
FT                   /note="Protein PA-X"
FT                   /id="PRO_0000419351"
SQ   SEQUENCE   252 AA;  29378 MW;  7D318D48B6267FDE CRC64;
     MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINERGES
     IIVESGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKENRFIEI
     GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
     EMASRGLWDS FVSPREAKRQ LKKDLKSQEQ CAGLPTKVSH RTSPALKTLE PMWMDSNRTA
     TLRASFLKCP KK