ID   PAX_I34A1               Reviewed;         252 AA.
AC   P0CK64;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   07-OCT-2020, entry version 28.
DE   RecName: Full=Protein PA-X;
GN   Name=PA;
OS   Influenza A virus (strain A/Puerto Rico/8/1934 H1N1).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=211044;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7060132; DOI=10.1016/0092-8674(82)90348-8;
RA   Fields S., Winter G.;
RT   "Nucleotide sequences of influenza virus segments 1 and 3 reveal mosaic
RT   structure of a small viral RNA segment.";
RL   Cell 28:303-313(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11779399; DOI=10.1098/rstb.2001.0979;
RA   Schickli J.H., Flandorfer A., Nakaya T., Martinez-Sobrido L.,
RA   Garcia-Sastre A., Palese P.;
RT   "Plasmid-only rescue of influenza A virus vaccine candidates.";
RL   Philos. Trans. R. Soc. Lond., B, Biol. Sci. 356:1965-1973(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA], AND REVERSE GENETICS.
RX   PubMed=15163504; DOI=10.1016/j.virusres.2004.02.028;
RA   de Wit E., Spronken M.I.J., Bestebroer T.M., Rimmelzwaan G.F.,
RA   Osterhaus A.D.M.E., Fouchier R.A.M.;
RT   "Efficient generation and growth of influenza virus A/PR/8/34 from eight
RT   cDNA fragments.";
RL   Virus Res. 103:155-161(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V.,
RA   Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H.,
RA   Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y.,
RA   Bolotov P., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.;
RT   "The NIAID influenza genome sequencing project.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the modulation of host immune response.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=PA-X;
CC         IsoId=P0CK64-1; Sequence=Displayed;
CC       Name=PA;
CC         IsoId=P03433-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the influenza viruses PA-X family.
CC       {ECO:0000305}.
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DR   EMBL; V01106; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; AF389117; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; EF467820; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; CY009449; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   RefSeq; YP_006495785.1; NC_002022.1. [P0CK64-1]
DR   SMR; P0CK64; -.
DR   GeneID; 13229134; -.
DR   KEGG; vg:13229134; -.
DR   Proteomes; UP000009255; Genome.
DR   Proteomes; UP000116373; Genome.
DR   Proteomes; UP000170967; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.91.90; -; 1.
DR   InterPro; IPR001009; PA/PA-X.
DR   InterPro; IPR038372; PA/PA-X_sf.
DR   Pfam; PF00603; Flu_PA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ribosomal frameshifting.
FT   CHAIN           1..252
FT                   /note="Protein PA-X"
FT                   /id="PRO_0000419347"
SQ   SEQUENCE   252 AA;  29423 MW;  568F665AAE504C4C CRC64;
     MEDFVRQCFN PMIVELAEKT MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINEQGES
     IIVELGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKENRFIEI
     GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
     EMASRGLWDS FVSPREEKRQ LKKGLKSQEQ CASLPTKVSR RTSPALKILE PMWMDSNRTA
     TLRASCLKCP KK