PAX_I47A0
ID PAX_I47A0 Reviewed; 252 AA.
AC P0CK88;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 1.
DT 02-JUN-2021, entry version 21.
DE RecName: Full=Protein PA-X;
GN Name=PA;
OS Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX NCBI_TaxID=380282;
OH NCBI_TaxID=8782; Aves.
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=8879138; DOI=10.1016/0168-1702(96)01329-9;
RA Smeenk C.A., Wright K.E., Burns B.F., Thaker A.J., Brown E.G.;
RT "Mutations in the hemagglutinin and matrix genes of a virulent influenza
RT virus variant, A/FM/1/47-MA, control different stages in pathogenesis.";
RL Virus Res. 44:79-95(1996).
CC -!- FUNCTION: May play a role in the modulation of host immune response.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Ribosomal frameshifting; Named isoforms=2;
CC Name=PA-X;
CC IsoId=P0CK88-1; Sequence=Displayed;
CC Name=PA;
CC IsoId=Q82570-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the influenza viruses PA-X family.
CC {ECO:0000305}.
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DR EMBL; X99039; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR EMBL; AJ238020; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR SMR; P0CK88; -.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR Gene3D; 3.40.91.90; -; 1.
DR InterPro; IPR001009; PA/PA-X.
DR InterPro; IPR038372; PA/PA-X_sf.
DR Pfam; PF00603; Flu_PA; 1.
PE 3: Inferred from homology;
KW Ribosomal frameshifting.
FT CHAIN 1..252
FT /note="Protein PA-X"
FT /id="PRO_0000419371"
FT REGION 202..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 252 AA; 29507 MW; 02DDC2A1727C6B28 CRC64;
MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINEQGRS
IIVELGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKEDRFIEI
GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
EMASRGLWDS FVNPREAKRQ LKKNLKSQEQ CATSPTKVSR RTSPALRILE PMWMDSNRTA
TLRASFLKCP KK