ID   PAX_I60A0               Reviewed;         252 AA.
AC   P0CK65;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   02-DEC-2020, entry version 24.
DE   RecName: Full=Protein PA-X;
GN   Name=PA;
OS   Influenza A virus (strain A/Ann Arbor/6/1960 H2N2).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=384498;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2974219; DOI=10.1016/s0042-6822(88)90118-3;
RA   Cox N.J., Kitame F., Kendal A.P., Maassab H.F., Naeve C.;
RT   "Identification of sequence changes in the cold-adapted, live attenuated
RT   influenza vaccine strain, A/Ann Arbor/6/60 (H2N2).";
RL   Virology 167:554-567(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15380362; DOI=10.1016/j.virol.2004.06.009;
RA   Lindstrom S.E., Cox N.J., Klimov A.;
RT   "Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-
RT   1972: evidence for genetic divergence and multiple reassortment events.";
RL   Virology 328:101-119(2004).
CC   -!- FUNCTION: May play a role in the modulation of host immune response.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=PA-X;
CC         IsoId=P0CK65-1; Sequence=Displayed;
CC       Name=PA;
CC         IsoId=P21427-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the influenza viruses PA-X family.
CC       {ECO:0000305}.
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DR   EMBL; M23974; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; AY209994; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0CK65; -.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.91.90; -; 1.
DR   InterPro; IPR001009; PA/PA-X.
DR   InterPro; IPR038372; PA/PA-X_sf.
DR   Pfam; PF00603; Flu_PA; 1.
PE   3: Inferred from homology;
KW   Ribosomal frameshifting.
FT   CHAIN           1..252
FT                   /note="Protein PA-X"
FT                   /id="PRO_0000419348"
SQ   SEQUENCE   252 AA;  29353 MW;  3C8943A381B7944F CRC64;
     MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINEQGES
     IIVELDDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKENRFIEI
     GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
     EMASRGLWDS FISPKEAKKQ LKKDLKSQGQ CAGSPTKVSR RTSPALRILE PMWMDSNRTA
     TLRASFLKCP KK