ID   PAX_I68A4               Reviewed;         252 AA.
AC   P0DJR7;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   07-OCT-2020, entry version 29.
DE   RecName: Full=Protein PA-X;
GN   Name=PA;
OS   Influenza A virus (strain A/Hong Kong/1/1968 H3N2).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX   NCBI_TaxID=506350;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9721; Cetacea (whales).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9709; Phocidae (true seals).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=A/Hong Kong/1/1968, and Isolate MA20c;
RX   PubMed=11371620; DOI=10.1073/pnas.111165798;
RA   Brown E.G., Liu H., Kit L.C., Baird S., Nesrallah M.;
RT   "Pattern of mutation in the genome of influenza A virus on adaptation to
RT   increased virulence in the mouse lung: identification of functional
RT   themes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:6883-6888(2001).
CC   -!- FUNCTION: May play a role in the modulation of host immune response.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=PA-X;
CC         IsoId=P0DJR7-1; Sequence=Displayed;
CC       Name=PA;
CC         IsoId=Q91MA9-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the influenza viruses PA-X family.
CC       {ECO:0000305}.
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DR   EMBL; AF348174; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; AF348175; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0DJR7; -.
DR   Proteomes; UP000142359; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.91.90; -; 1.
DR   InterPro; IPR001009; PA/PA-X.
DR   InterPro; IPR038372; PA/PA-X_sf.
DR   Pfam; PF00603; Flu_PA; 1.
PE   3: Inferred from homology;
KW   Ribosomal frameshifting.
FT   CHAIN           1..252
FT                   /note="Protein PA-X"
FT                   /id="PRO_0000419380"
FT   VARIANT         133
FT                   /note="E -> G (in strain: Isolate MA20c)"
SQ   SEQUENCE   252 AA;  29364 MW;  EEE55C5974365E66 CRC64;
     MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINEQGES
     IVVELDDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKENRFIEI
     GVTRREVHIY YLEKANKIKS ENTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
     EMANRGLWDS FVSPKEAKKQ LKKDLKSQGQ CAGLPTKVSR RTSPALRILE PMWMDSNRTA
     TLRASFLKCP KK